
Low Rate Loading Regenerated Degenerated Discs
Goal of the Study?
The regenerative potential of a degenerated disc has been questioned over the years. In this ISSLS prize-winning study[1.ISSLS Prize in Bioengineering Science 2022: low rate cyclic loading as a therapeutic strategy for intervertebral…

Mechanical Strain Accelerates Intervertebral Disc Degeneration Through Circadian Rhythm Disruption
Goal of the Study?
The intervertebral disc often plays a role in back pain. In this study[1.Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm] researchers were curious about how…

Fundamentals of Intervertebral Disc Degeneration
Goal of the Study?
In this review article from the Annals of Weill Cornell Neurological Surgery[1.Fundamentals of Intervertebral Disc Degeneration] the authors’ goals were twofold: a) Cover the underlying pathophysiology and risk factors…

Vacuum Phenomenon – What is it and can it tell us anything about the dynamics of the spine?
Goal of the Study?
Intradiscal vacuum phenomenon is a commonly observed radiological finding in the spine but not much is known about its pathophysiology. A recent paper was published in The European Spine Journal[1.Advanced disc degeneration,…

Clinical anatomy of the lumbar sinuvertebral nerve with regard to discogenic low back pain and review of literature
Goal of the Study?
In this clinical anatomical study and literature review article from the European Spine Journal [1. Clinical anatomy of the lumbar sinuvertebral nerve with regard to discogenic low back pain and review of literature] the…

Increased Expression in Nucleus Pulposus Cells in Response to High Oxygen
Goal of the Study?
In this qualitative primary research study from the Oxidative Medicine and Cellular Longevity Journal [1. Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells in Response to High Oxygen Tension Protects against…

Clinical and MRI findings in degenerative lumbar spinal stenosis
Goal of the Study?
In this cross-sectional study from the European Spine Journal [1. Clinical and MRI findings in lumbar spinal stenosis: baseline data from the NORDSTEN study] the authors’ primary goal was to describe the relationship…

Correlation Between Proteolytic Enzymes and Micro Angiogenesis in Degenerative Intervertebral Disc Nucleus
Goal of the Study?
In this case-control study from the Journal of Investigative Surgery [1. Correlation Between Proteolytic Enzymes and Micro Angiogenesis in Degenerative Intervertebral Disc Nucleus] the authors’ goal was to determine if…

Compression and Bending (Not only Bending) Caused Disc Herniation in this Animal Model Research
Goal of the Study?
In this primary research article [1. A novel rat tail disc degeneration model induced by static bending and compression], the authors aim to establish an animal model that can be extrapolated to the complex mechanical load…