Loading the Spine in MRI
Loading the spine and the differences seen in MRI
Models of Disc Degeneration
What is the goal of the Study? This Study aims to learn more about in-vitro models of disc degeneration. In this review paper, the authors sought a clinical perspective on the current state of in-vitro modelling related to the disruption, overloading and biochemical changes within the intervertebral disc.1 Why are they doing this Study? Learning […]
Words and Diagnostic Labels of LBP Prognosis
Goal of the Study? The goal of this study is to learn more about a patient’s perception and expected outcome when a diagnosis is shared with them regarding their low back pain. In a recent paper published in the European Spine Journal1 the authors wanted to know how diagnostic labels influenced the participants. Did labelling […]
Disk Degeneration Higher than Reported in the Youth at this Hospital
Goal of the Study? The goal of this study1 was to have a closer look at the younger population’s lower back MRI findings. Most epidemiological investigations on youth and back pain MRIs have looked at developed countries. In this study, the researchers looked at an underdeveloped country, Uganda, along with the youth’s clinical features of […]
Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation
Goal of the Study? In this histological analysis article from the Arthritis Research and Therapy Journal 1 the authors’ goal was to better understand the mechanism behind annulus fibrosus failure and the progression of intervertebral disc herniation. Why are they doing this study? Intervertebral Disc Herniation (IVD herniation) disorders are a major cause of […]
Three-dimensional Modelling Dynamic Diurnal Disc Changes – Posterior and Anterior Look with MRI
Goal of the Study? We all know that LBP is a worldwide problem. Yet, the disc and its functional relationship to low back pain are poorly understood. These researchers worked to use MRI and three-dimensional modelling to measure in-vivo shape changes of intervertebral discs over the dynamic diurnal cycle1. They set out to create a […]
Vacuum Phenomenon – What is it and can it tell us anything about the dynamics of the spine?
Goal of the Study? Intradiscal vacuum phenomenon is a commonly observed radiological finding in the spine but not much is known about its pathophysiology. A recent paper was published in The European Spine Journal1 and sought to explore more about this curious phenomenon by looking at patients with it and to see if the anatomical […]
Correlation Between Proteolytic Enzymes and Micro Angiogenesis in Degenerative Intervertebral Disc Nucleus
Goal of the Study? In this case-control study from the Journal of Investigative Surgery 1 the authors’ goal was to determine if a correlation exists between proteolytic enzymes and micro angiogenesis in degenerative intervertebral disc nucleus. Why are they doing this study? Current pathological studies of intervertebral disc degeneration reveal apoptosis of nucleus pulposus […]
Correlation Between Proteolytic Enzymes and Microangiogenesis in Degenerative Intervertebral Disc Nucleus
Goal of the review? The goal of the article, 1 explores the molecular level of intervertebral disc degeneration. Specifically, the authors examine the correlation between proteolytic enzymes, microvascular formation, or neve fibre ingrowth in the intervertebral disc nucleus. Why are they doing this review? To aid in diagnosis and treatment, the authors argue that […]