Effect of overload on changes in mechanical and structural properties of disc biomechanics

disc biomechanics

Goal of the Study? In this primary research study from the Biomechanics and Modeling in Mechanobiology Journal1 the authors analyzed structural and mechanical properties in the Intervertebral Disc (IVD) of 10 lumbar spine regions collected post mortem from domestic pigs.  The goal was to analyze the effects of long-term cyclic loading in the hope of […]

The neurobiology of skeletal pain


Goal of the review? In this review 1, the authors focus on recent advances in understanding the nociceptive and neuropathic components of pain, as well as treatments for skeletal pain.    Why are they doing this review? Skeletal pain neurobiology is widely prevalent and has a significant impact on an individual’s quality of life and […]

Mechanotherapy: how physical therapists’ prescription of exercise promotes tissue repair


Goal of the Study? In this study 1, the goal is to answer how physical exercise promotes tissue healing in bone, muscle, tendon, and cartilage.   Why are they doing this study? Physical therapists and other clinicians prescribe exercise to address muscle tears, non-inflammatory arthropathies and controlled loading after injuries. This practice is in line […]

Cyclic Mechanical Tension and Intervertebral Disc Degeneration

intervertebral disc degeneration, 3d modeling

Mechanobiology Research Low back pain is a huge burden on our limited resources with limited knowledge of its pathophysiology. It is widely known that intervertebral disc degeneration (IDD) is intimately related, with the degree of degeneration associated with the severity of low back pain. The characteristics of intervertebral disc degeneration include disc height loss, proteoglycan loss, loss […]

Dynamic Loading of Intervertebral Disc Maintains Cells

Dynamic, Disc , Modeling, Research

Dynamic Loading of the Intervertebral Disc – Ex vivo culturing and what can we learn? For decades, the study of the intervertebral disc and the process that leads to degeneration has kept researchers very busy. This quest to fully understand the mechanisms that lead to water loss and proteoglycan content of the nucleus pulposus seems […]

Life after death – regeneration of degenerated discs?

regeneration - degenerated disc

Will there be regeneration of degenerated discs? For decades a degenerated disc was thought to be a slow descent towards spinal dysfunction. However, when searching out terms like “degeneration” in PubMed, for example, the word “regeneration” is starting to show up in the searches along side degeneration. Recently, at the Engineering in Medicine and Biology Society, 2004. […]