In a recent paper published in Arthritis and Research Therapy, researchers showed how mechanical disc strain causes inflammation and pain.
The cost of treating chronic conditions, including osteoarthritis (OA) and low back pain, currently accounts for a sizeable portion of global healthcare budgets. In order to develop more effective treatment plans, lower morbidity, and lessen the total economic impact of such diseases, the current healthcare paradigm is turning toward a deeper understanding of the underlying causes and pathological mechanisms of such diseases. Currently ranked sixth among the most expensive treatable chronic illnesses, low back pain is a debilitating condition that requires large financial resources for treatment.
It is believed that excessive mechanical loading of intervertebral discs (IVDs) alters the matrix’s characteristics and affects the disc cells’ metabolism, causing degenerative disc disease and the emergence of discogenic pain. However, the mechanism by which mechanical strain causes these changes is poorly understood. This study1examined the cellular and molecular alterations in human intervertebral disc cells exposed to high mechanical strain (HMS) at low frequency, as well as which inflammatory receptors and cytokines were activated. The effects of these metabolic alterations on neural differentiation were also investigated to ascertain a role in the emergence of disc degeneration and discogenic pain.
Degenerative disc disease (DDD), also known as intervertebral disc (IVD) degeneration, is frequently blamed for low-back pain. Upregulated inflammatory cytokines, loss of resident cell populations, changed biomechanics, uneven loading of the spine, and excessive mechanical stretching of tissue and cells are all frequently mentioned causes of degeneration. The underlying mechanical and chemical causes of disc degeneration are still poorly understood.
In vivo discogenic pain and possible degeneration are directly correlated with high tensile cellular strain, secretory factors, neoinnervation, and this work provide compelling evidence for this relationship.
Spine Models to Help Improve Outcomes
Dynamic Disc Designs spine education models help explain mechanical factors to patients in a platform to improve clinical outcomes through teaching avoidance behaviours that contribute to ongoing intradiscal inflammation. Our Professional LxH Model features a dynamically bulging disc and neoinnervation to radial fissures. Explore how ddd can make a difference.