Research Read in Full Text to Help Develop ddd Models


Abbas, J., Hamoud, K., Masharawi, Y. M., May, H., Hay, O., Medlej, B., … Hershkovitz, I. (2010). Ligamentum flavum thickness in normal and stenotic lumbar spines. Spine, 35(12), 1225–1230. doi:10.1097/BRS.0b013e3181bfca15

Abbas, J., Hamoud, K., Peleg, S., May, H., Masharawi, Y., Cohen, H., … Hershkovitz, I. (2011). Facet Joints Arthrosis in Normal and Stenotic Lumbar Spines. Spine, 36(24), E1541–E1546. doi:10.1097/BRS.0b013e318210c889

Accadbled, F., Laffosse, J.-M., Ambard, D., Gomez-Brouchet, A., de Gauzy, J. S., & Swider, P. (2008). Influence of location, fluid flow direction, and tissue maturity on the macroscopic permeability of vertebral end plates. Spine, 33(6), 612–619. doi:10.1097/BRS.0b013e318166e0d7

Acoustic monopoles, dipoles, and quadrupoles: An experiment revisited. (n.d.). Retrieved March 25, 2015, from

Adams, M. a, Dolan, P., Hutton, W. C., & Porter, R. W. (1990). Diurnal changes in spinal mechanics and their clinical significance. The Journal of Bone and Joint Surgery, 72-B, 266–270.

Adams, M. a, Freeman, B. J., Morrison, H. P., Nelson, I. W., & Dolan, P. (2000). Mechanical initiation of intervertebral disc degeneration. Spine, 25(13), 1625–1636. doi:10.1097/00007632-200007010-00005

Adams, M. a, & Roughley, P. J. (2006). What is intervertebral disc degeneration, and what causes it? Spine, 31(18), 2151–2161. doi:10.1097/01.brs.0000231761.73859.2c

Adams, M. a., & Dolan, P. (1995). Recent advances in lumbar spinal mechanics and their clinical significance. Clinical Biomechanics, 10(1), 3–19. doi:10.1016/0268-0033(95)90432-9

Adams, M. a., Dolan, P., & McNally, D. S. (2009). The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology. Matrix Biology, 28, 384–389. doi:10.1016/j.matbio.2009.06.004

Adams, M. a., Lama, P., Zehra, U., & Dolan, P. (2014). Why do some intervertebral discs degenerate, when others (in the same spine) do not? Clinical Anatomy, 00(April). doi:10.1002/ca.22404

Adams, M. a., Stefanakis, M., & Dolan, P. (2010). Healing of a painful intervertebral disc should not be confused with reversing disc degeneration: Implications for physical therapies for discogenic back pain. Clinical Biomechanics, 25, 961–971. doi:10.1016/j.clinbiomech.2010.07.016

Ahn, H. S., & DiAngelo, D. J. (2008). A biomechanical study of artificial cervical discs using computer simulation. Spine, 33(8), 883–892. doi:10.1097/BRS.0b013e31816b1f5c

Ahn, T.-J., Lee, S.-H., Choi, G., Ahn, Y., Liu, W. C., Kim, H.-J., & Lee, H.-Y. (2009). Effect of intervertebral disk degeneration on spinal stenosis during magnetic resonance imaging with axial loading. Neurologia Medico-Chirurgica, 49, 242–247; discussion 247. doi:10.2176/nmc.49.242

Akyuz, E., Braun, J. T., Brown, N. a T., & Bachus, K. N. (2006). Static versus dynamic loading in the mechanical modulation of vertebral growth. Spine, 31(25), E952–E958. doi:10.1097/01.brs.0000248810.77151.22

Alamin, T. F., Kim, M. J., & Agarwal, V. (2011). Provocative lumbar discography versus functional anesthetic discography: A comparison of the results of two different diagnostic techniques in 52 patients with chronic low back pain. Spine Journal, 11, 756–765. doi:10.1016/j.spinee.2011.07.021

Albert, H. B., Briggs, A. M., Kent, P., Byrhagen, A., Hansen, C., & Kjaergaard, K. (2011). The prevalence of MRI-defined spinal pathoanatomies and their association with Modic changes in individuals seeking care for low back pain. European Spine Journal, 20, 1355–1362. doi:10.1007/s00586-011-1794-6

Albert, H. B., Kjaer, P., Jensen, T. S., Sorensen, J. S., Bendix, T., & Manniche, C. (2008). Modic changes, possible causes and relation to low back pain. Medical Hypotheses, 70, 361–368. doi:10.1016/j.mehy.2007.05.014

Albert, H. B., & Manniche, C. (2007). Modic changes following lumbar disc herniation. European Spine Journal, 16, 977–982. doi:10.1007/s00586-007-0336-8

Alexander, L. a, Hancock, E., Agouris, I., Smith, F. W., & MacSween, A. (2007). The response of the nucleus pulposus of the lumbar intervertebral discs to functionally loaded positions. Spine, 32(14), 1508–1512. doi:10.1097/BRS.0b013e318067dccb

Alkhatib, B., Rosenzweig, D. H., Krock, E., Roughley, P. J., Beckman, L., Steffen, T., … Scoliosis, M. (2014). ACUTE MECHANICAL INJURY OF THE HUMAN INTERVERTEBRAL DISC : LINK TO DEGENERATION AND PAIN, (514).

Alperin, N., Lee, S. H., Sivaramakrishnan, A., & Hushek, S. G. (2005). Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies. Journal of Magnetic Resonance Imaging, 22, 591–596. doi:10.1002/jmri.20427

Al-Rawahi, M., Luo, J., Pollintine, P., Dolan, P., & Adams, M. a. (2011). Mechanical function of vertebral body osteophytes, as revealed by experiments on cadaveric spines. Spine, 36(10), 770–777. doi:10.1097/BRS.0b013e3181df1a70

Alyas, F., Connell, D., & Saifuddin,  a. (2008). Upright positional MRI of the lumbar spine. Clinical Radiology, 63, 1035–1048. doi:10.1016/j.crad.2007.11.022

Ammendolia, C., & Chow, N. (2015). Clinical Outcomes for Neurogenic Claudication Using a Multimodal Program for Lumbar Spinal Stenosis: A Retrospective Study. Journal of Manipulative and Physiological Therapeutics, 1–7. doi:10.1016/j.jmpt.2014.12.006

An anti-creep Sept 6, 2006. (n.d.).

An, H. S., Anderson, P. a, Haughton, V. M., Iatridis, J. C., Kang, J. D., Lotz, J. C., … Weinstein, J. N. (2004). Introduction: disc degeneration: summary. Spine, 29(23), 2677–2678. doi:10.1097/01.brs.0000147573.88916.c6

An improved method of stature measurement for quantitative determination of spinal loading.pdf. (n.d.).

anatomy, biomechanics and surgical approach to synovial folds in the foot.PDF. (n.d.).

Anderson, P. a, & Rouleau, J. P. (2004). Intervertebral disc arthroplasty. Spine, 29(23), 2779–2786. doi:10.1097/01.brs.0000146460.11591.8a

Andersson, G. B. (1999). Epidemiological features of chronic low-back pain. Lancet, 354, 581–585. doi:10.1016/S0140-6736(99)01312-4

Anderst, W. J., Donaldson, W. F., Lee, J. Y., & Kang, J. D. (2014). Continuous cervical spine kinematics during in vivo dynamic flexion-extension. Spine Journal, 14(7), 1221–1227. doi:10.1016/j.spinee.2013.08.019

Anjarwalla, N. K., Brown, L. C., & McGregor,  a. H. (2007). The outcome of spinal decompression surgery 5 years on. European Spine Journal, 16, 1842–1847. doi:10.1007/s00586-007-0393-z

Aoki, Y., Ohtori, S., Ino, H., Douya, H., Ozawa, T., Saito, T., … Takahashi, K. (2004). Disc inflammation potentially promotes axonal regeneration of dorsal root ganglion neurons innervating lumbar intervertebral disc in rats. Spine, 29(23), 2621–2626. doi:10.1097/01.brs.0000146051.11574.b4

Aota, Y., Iizuka, H., Ishige, Y., Mochida, T., Yoshihisa, T., Uesugi, M., & Saito, T. (2007). Effectiveness of a lumbar support continuous passive motion device in the prevention of low back pain during prolonged sitting. Spine, 32(23), E674–E677. doi:10.1097/BRS.0b013e318158cf3e

Apkarian,  a V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004). Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 24(46), 10410–10415. doi:10.1523/JNEUROSCI.2541-04.2004

Arai, T., Fujishima, K., Kobayashi, H., Yamamoto, T., Mori, K., Maeda, M., … Okuma, Y. (2007). Pseudoathetosis caused by migrated cervical disc. Parkinsonism and Related Disorders, 13, 59–61. doi:10.1016/j.parkreldis.2006.03.008

Architecture, M. (n.d.). Microvascular Architecture.

Arendt-nielsen, L., Eskehave, T. N., Egsgaard, L. L., Petersen, K. K., Graven-nielsen, T., Hoeck, H. C., … Bay-jensen, A. C. (2014). Association Between Experimental Pain Biomarkers and Serologic Markers in Patients With Different Degrees of Painful Knee Osteoarthritis, 66(12), 3317–3326. doi:10.1002/art.38856

Arkill, K. P., & Winlove, C. P. (2006). Fatty acid transport in articular cartilage. Archives of Biochemistry and Biophysics, 456, 71–78. doi:10.1016/

Arkill, K. P., & Winlove, C. P. (2008). Solute transport in the deep and calcified zones of articular cartilage. Osteoarthritis and Cartilage, 16, 708–714. doi:10.1016/j.joca.2007.10.001

Arun, R., Freeman, B. J. C., Scammell, B. E., McNally, D. S., Cox, E., & Gowland, P. (2009). 2009 ISSLS Prize Winner: What influence does sustained mechanical load have on diffusion in the human intervertebral disc?: an in vivo study using serial postcontrast magnetic resonance imaging. Spine, 34(21), 2324–2337. doi:10.1097/BRS.0b013e3181b4df92

Athiviraham, A., Wali, Z. a, & Yen, D. (2011). Predictive factors influencing clinical outcome with operative management of lumbar spinal stenosis. The Spine Journal : Official Journal of the North American Spine Society, 11(7), 613–617. doi:10.1016/j.spinee.2011.03.008

Au, G., Cook, J., & McGill, S. M. (2001). Spinal shrinkage during repetitive controlled torsional, flexion and lateral bend motion exertions. Ergonomics, 44, 373–381. doi:10.1080/00140130010008129

Audible sounds associated with spinal manipulation – a snap- ­ shot summary report ( Nov 2012 ) • Key messages. (2012), (Nov), 1–8.

Auerbach, J. D., Ballester, C. M., Hammond, F., Carine, E. T., Balderston, R. a., & Elliott, D. M. (2010). The effect of implant size and device keel on vertebral compression properties in lumbar total disc replacement. Spine Journal, 10(4), 333–340. doi:10.1016/j.spinee.2010.01.008

Auerbach, J. D., Johannessen, W., Borthakur, A., Wheaton, A. J., Dolinskas, C. a, Balderston, R. a, … Elliott, D. M. (2006). In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 15 Suppl 3, S338–S344. doi:10.1007/s00586-006-0083-2

Auleley, G. R., Rousselin, B., Ayral, X., Edouard-Noel, R., Dougados, M., & Ravaud, P. (1998). Osteoarthritis of the hip: agreement between joint space width measurements on standing and supine conventional radiographs. Annals of the Rheumatic Diseases, 57, 519–523. doi:10.1136/ard.57.9.519

Auteroche, P. (1983). Original Papers Innervation of the Zygapophyseal Joints of the Lumbar Spine, 17–28.

Avadhani, A., Rajasekaran, S., & Shetty, A. P. (2010). Comparison of prognostic value of different MRI classifications of signal intensity change in cervical spondylotic myelopathy. The Spine Journal : Official Journal of the North American Spine Society, 10(6), 475–485. doi:10.1016/j.spinee.2010.03.024

Bailey, J. F., Hargens, A. R., Cheng, K. K., & Lotz, J. C. (2014). Effect of microgravity on the biomechanical properties of lumbar and caudal intervertebral discs in mice. Journal of Biomechanics, 1–6. doi:10.1016/j.jbiomech.2014.07.005

Bailey, J. F., Liebenberg, E., Degmetich, S., & Lotz, J. C. (2011). Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra. Journal of Anatomy, 218, 263–270. doi:10.1111/j.1469-7580.2010.01332.x

Baker, N. D., Klein, M. J., Greenspan,  a, & Neuwirth, M. (1986). Symptomatic vertebral hemangiomas: a report of four cases. Skeletal Radiology, 15, 458–463. doi:10.1007/BF00355106

Bakker, E. W. P., Verhagen, A. P., Lucas, C., Koning, H. J. C. M. F., De Haan, R. J., & Koes, B. W. (2007). Daily spinal mechanical loading as a risk factor for acute non-specific low back pain: A case-control study using the 24-Hour Schedule. European Spine Journal, 16, 107–113. doi:10.1007/s00586-006-0111-2

Bakker, E. W. P., Verhagen, A. P., van Trijffel, E., Lucas, C., & Koes, B. W. (2009). Spinal mechanical load as a risk factor for low back pain: a systematic review of prospective cohort studies. Spine, 34(8), E281–E293. doi:10.1097/BRS.0b013e318195b257

Bakker, M., & Miller, J. (2004). Does an audible release improve the outcome of a chiropractic adjustment? The Journal of the Canadian Chiropractic Association, 48(3), 237–9. Retrieved from

Bakker, M., Miller, J., Tutor, S. C., & Ra, S. (n.d.). Clinical Brief Does an audible release improve the outcome of a chiropractic adjustment ? Report by, 48(3), 237–239.

Baldwin, N. G. (2002). Lumbar disc disease: the natural history. Neurosurgical Focus, 13(2), E2. doi:10.3171/foc.2002.13.2.3

Balkovec, C., & McGill, S. (2012). Extent of nucleus pulposus migration in the annulus of porcine intervertebral discs exposed to cyclic flexion only versus cyclic flexion and extension. Clinical Biomechanics, 27, 766–770. doi:10.1016/j.clinbiomech.2012.05.006

Barion,  a, & Zee, P. (2007). A clinical approach to circadian rhythm sleep disorders. Sleep Medicine. doi:10.1016/j.sleep.2006.11.017.A

Barr, J. S. (1951). Low-back and sciatic pain; results of treatment. The Journal of Bone and Joint Surgery. American Volume.

Batsis, J. a., & Phy, M. P. (2005). Intracranial hypotension: Aggravation of headache at high altitude. Headache, 45, 380–384. doi:10.1111/j.1526-4610.2005.05077_2.x

Battié, M. C., & Videman, T. (2006). Lumbar disc degeneration: epidemiology and genetics. The Journal of Bone and Joint Surgery. American Volume, 88 Suppl 2, 3–9. doi:10.2106/JBJS.E.01313

Beach, T. a C., Parkinson, R. J., Stothart, J. P., & Callaghan, J. P. (2005). Effects of prolonged sitting on the passive flexion stiffness of the in vivo lumbar spine. Spine Journal, 5, 145–154. doi:10.1016/j.spinee.2004.07.036

Beastall, J., Karadimas, E., Siddiqui, M., Nicol, M., Hughes, J., Smith, F., & Wardlaw, D. (2007). The Dynesys Lumbar Spinal Stabilization System. Spine, 32(6), 685–690. doi:10.1097/01.brs.0000257578.44134.fb

Beattie, P. F., Donley, J. W., Arnot, C. F., & Miller, R. (2009). The change in the diffusion of water in normal and degenerative lumbar intervertebral discs following joint mobilization compared to prone lying. The Journal of Orthopaedic and Sports Physical Therapy, 39(1), 4–11. doi:10.2519/jospt.2009.2994

Beazell, J. R., Mullins, M., & Grindstaff, T. L. (2010). Lumbar instability: an evolving and challenging concept. The Journal of Manual & Manipulative Therapy, 18, 9–14. doi:10.1179/106698110X12595770849443

Beckstein, J. C., Sen, S., Schaer, T. P., Vresilovic, E. J., & Elliott, D. M. (2008). Comparison of animal discs used in disc research to human lumbar disc: axial compression mechanics and glycosaminoglycan content. Spine, 33(6), E166–E173. doi:10.1097/BRS.0b013e31824d911c

Been, E., Li, L., Hunter, D. J., & Kalichman, L. (2011). Geometry of the vertebral bodies and the intervertebral discs in lumbar segments adjacent to spondylolysis and spondylolisthesis: Pilot study. European Spine Journal, 20, 1159–1165. doi:10.1007/s00586-010-1660-y

Beffa, R., & Mathews, R. (2004). Does the adjustment cavitate the targeted joint? an investigation into the location of cavitation sounds. Journal of Manipulative and Physiological Therapeutics, 27, 118–122. doi:10.1016/j.jmpt.2003.12.014

Bel, E. Del. (2014). Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration, 1–13. doi:10.1371/journal.pone.0113161

Belavý, D. L., Armbrecht, G., Richardson, C. a, Felsenberg, D., & Hides, J. a. (2011). Muscle atrophy and changes in spinal morphology: is the lumbar spine vulnerable after prolonged bed-rest? Spine, 36(2), 137–145. doi:10.1097/BRS.0b013e3181cc93e8

Belavý, D. L., Richardson, C. a, Wilson, S. J., Rittweger, J., & Felsenberg, D. (2007). Superficial lumbopelvic muscle overactivity and decreased cocontraction after 8 weeks of bed rest. Spine, 32(1), E23–E29. doi:10.1097/01.brs.0000250170.53746.27

Belyavin, A. J. (1992). The duration of REM sleep episodes in normal sleep. Public Health, (December 1991), 128–131.

Bendix, T., Kjaer, P., & Korsholm, L. (2008). Burned-out discs stop hurting: fact or fiction? Spine, 33(25), E962–E967. doi:10.1097/BRS.0b013e31818804b3

Benedek, T. G. (2006). A history of the understanding of cartilage. Osteoarthritis and Cartilage, 14, 203–209. doi:10.1016/j.joca.2005.08.014

Benjamin, T. B., & Ellis, A. T. (1966). The Collapse of Cavitation Bubbles and the Pressures thereby Produced against Solid Boundaries. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 260(1110), 221–240. doi:10.1098/rsta.1966.0046

Benneker, L. M., Heini, P. F., Alini, M., Anderson, S. E., & Ito, K. (2005). 2004 Young Investigator Award Winner: vertebral endplate marrow contact channel occlusions and intervertebral disc degeneration. Spine, 30(2), 167–173. doi:10.1097/01.brs.0000150833.93248.09

Bereznick, D. E., Pecora, C. G., Ross, J. K., & McGill, S. M. (2008). The refractory period of the audible “crack” after lumbar manipulation: a preliminary study. Journal of Manipulative and Physiological Therapeutics, 31(3), 199–203. doi:10.1016/j.jmpt.2008.02.002

Berg, S., Tropp, H. T., & Leivseth, G. (2011). Disc height and motion patterns in the lumbar spine in patients operated with total disc replacement or fusion for discogenic back pain. Results from a randomized controlled trial. Spine Journal, 11(11), 991–998. doi:10.1016/j.spinee.2011.08.434

Berger-Roscher, N., Galbusera, F., Rasche, V., & Wilke, H.-J. (2015). Intervertebral disc lesions: visualisation with ultra-high field MRI at 11.7 T. European Spine Journal. doi:10.1007/s00586-015-4146-0

Bergknut, N., Rutges, J. P. H. J., Kranenburg, H.-J. C., Smolders, L. a., Hagman, R., Smidt, H.-J., … Dhert, W. J. a. (2012). The Dog as an Animal Model for Intervertebral Disc Degeneration? Spine, 37, 351–358. doi:10.1097/BRS.0b013e31821e5665

Bialosky, J. E., Bishop, M. D., Robinson, M. E., & George, S. Z. (2010). The Relationship of the Audible Pop to Hypoalgesia Associated With High-Velocity, Low-Amplitude Thrust Manipulation: A Secondary Analysis of an Experimental Study in Pain-Free Participants. Journal of Manipulative and Physiological Therapeutics, 33(2), 117–124. doi:10.1016/j.jmpt.2009.12.008

Bialosky, J. E., George, S. Z., Horn, M. E., Price, D. D., Staud, R., & Robinson, M. E. (2014). Spinal manipulative therapy-specific changes in pain sensitivity in individuals with low back pain (NCT01168999). Journal of Pain, 15, 136–148. doi:10.1016/j.jpain.2013.10.005

Bian, Q., Liang, Q.-Q., Wan, C., Hou, W., Li, C.-G., Zhao, Y.-J., … Wang, Y.-J. (2011). Prolonged Upright Posture Induces Calcified Hypertrophy in the Cartilage End Plate in Rat Lumbar Spine. Spine, 36, 2011–2020. doi:10.1097/BRS.0b013e3181ffde92

Bibby, S. R. S., Jones, D. a., Lee, R. B., Yu, J., & Urban, J. P. G. (2001). The pathophysiology of the intervertebral disc. Joint Bone Spine, 68(figure 1), 537–542. doi:10.1016/S1297-319X(01)00332-3

Bijlsma, J. W. J., Berenbaum, F., & Lafeber, F. P. J. G. (2011). Osteoarthritis: An update with relevance for clinical practice. The Lancet, 377, 2115–2126. doi:10.1016/S0140-6736(11)60243-2

Bilgic, S., Sahin, B., Sonmez, O. F., Odaci, E., Colakoglu, S., Kaplan, S., & Ergur, H. (2005). A new approach for the estimation of intervertebral disc volume using the Cavalieri principle and computed tomography images. Clinical Neurology and Neurosurgery, 107, 282–288. doi:10.1016/j.clineuro.2004.08.001

Billy, G. G., Lemieux, S. K., & Chow, M. X. (2014a). Changes in Lumbar Disk Morphology Associated With Prolonged Sitting Assessed by Magnetic Resonance Imaging. PM and R, 6(9), 790–795. doi:10.1016/j.pmrj.2014.02.014

Billy, G. G., Lemieux, S. K., & Chow, M. X. (2014b). Changes in Lumbar Disk Morphology Associated With Prolonged Sitting Assessed by Magnetic Resonance Imaging. PM and R, 1–6. doi:10.1016/j.pmrj.2014.02.014

Biomechanical behavior of human intervertebral discs subjected to long lasting axial loading. (n.d.). Retrieved from

Biomechanics, J. (1995). an Analytical Model of Intervertebral Disc, 28(1), 53–68.

Blair Ford, M. (n.d.).

Blewis, M. E., Nugent-Derfus, G. E., Schmidt, T. a., Schumacher, B. L., & Sah, R. L. (2007). A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials, 13(858), 26–38. doi:10.1186/ar3216

Boe, D., Dfmmt, D., & Opupdipsebm, X. (2006). No Title, 30(11), 2005–2008.

Boecker, H., Bartenstein, P., Weindl,  a, Siebner, H. R., Fassbender, T., Munz, F., … Conrad, B. (1999). Sensory processing in Parkinson ’ s and Huntington ’ s disease Investigations with 3D H 215 O-PET. Word Journal Of The International Linguistic Association, 1651–1665.

Boesch, C. (n.d.). Influence Variations ’ MR Imaging of Lumbar and Vertebral Bodies : Radiology, 351–354.

Bogduk, N. (n.d.). The anatomical basis for spinal pain syndromes. Journal of Manipulative and Physiological Therapeutics.

Bogduk, N. (2011). On Cervical Zygapophysial Joint Pain After Whiplash. Spine, 36(25), S194–S199. doi:10.1097/BRS.0b013e3182387f1d

Bogduk, N., Aprill, C., & Derby, R. (2013). Lumbar discogenic pain: State-of-the-art review. Pain Medicine (United States), 14, 813–836. doi:10.1111/pme.12082

Bonnet, C. S., & Walsh, D. a. (2005). Osteoarthritis, angiogenesis and inflammation. Rheumatology, 44(1), 7–16. doi:10.1093/rheumatology/keh344

Boos, N., Weissbach, S., Rohrbach, H., Weiler, C., Spratt, K. F., & Nerlich, A. G. (2002). Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine, 27(23), 2631–2644. doi:10.1097/01.BRS.0000035304.27153.5B

Borenstein, D. (1996). Epidemiology, etiology, diagnostic evaluation, and treatment of low back pain. Current Opinion in Rheumatology, 8, 124–129.

Borenstein, D. (2004). Does Osteoarthritis of the Lumbar Spine Cause Chronic Low Back Pain ? Spine.

Boswell, M. V, Colson, J. D., Sehgal, N., Dunbar, E. E., & Epter, R. (2007). A systematic review of therapeutic facet joint interventions in chronic spinal pain. Pain Physician, 10, 229–253.

Botwin, K. P., & Gruber, R. D. (2003). Lumbar spinal stenosis: Anatomy and pathogenesis. Physical Medicine and Rehabilitation Clinics of North America, 14, 1–15. doi:10.1016/S1047-9651(02)00063-3

Bove, A. A. (2014). Diving medicine. American Journal of Respiratory and Critical Care Medicine, 189(12), 1479–86. doi:10.1164/rccm.201309-1662CI

Branch, K. B. G., & Division, I. P. (n.d.). Production of gas bubbles in fluids by tribonucleation, 524–527.

Branney, J., & Breen, A. C. (2014). Does inter-vertebral range of motion increase after spinal manipulation? A prospective cohort study. Chiropractic & Manual Therapies, 22(1), 24. doi:10.1186/s12998-014-0024-9

Brennen, C. E. (1995). Cavitation and Bubble Dynamics.

Brisby, H., & Hammar, I. (2007). Thalamic activation in a disc herniation model. Spine, 32(25), 2846–2852. doi:10.1097/BRS.0b013e31815b6526

Brismée, J.-M., Sizer, P. S., Dedrick, G. S., Sawyer, B. G., & Smith, M. P. (2009). Immunohistochemical and histological study of human uncovertebral joints: a preliminary investigation. Spine, 34(12), 1257–1263. doi:10.1097/BRS.0b013e31819b2b5d

Brodeur, R. The audible release associated with joint manipulation. Journal of Manipulative and Physiological Therapeutics, 18(3), 155–64. Retrieved from

Brodeur, R. (2007). The audible release associated with joint manipulation. Journal of Manipulative and Physiological Therapeutics, 18, 155–164.

Bronfort, G., Haas, M., Evans, R. L., & Bouter, L. M. Efficacy of spinal manipulation and mobilization for low back pain and neck pain: a systematic review and best evidence synthesis. The Spine Journal : Official Journal of the North American Spine Society, 4(3), 335–56. doi:10.1016/j.spinee.2003.06.002

Bronfort, G., Maiers, M. J., Evans, R. L., Schulz, C. a., Bracha, Y., Svendsen, K. H., … Transfeldt, E. E. (2011). Supervised exercise, spinal manipulation, and home exercise for chronic low back pain: A randomized clinical trial. Spine Journal, 11(7), 585–598. doi:10.1016/j.spinee.2011.01.036

Brown, M. F., Hukkanen, M. V, McCarthy, I. D., Redfern, D. R., Batten, J. J., Crock, H. V, … Polak, J. M. (1997). Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. The Journal of Bone and Joint Surgery. British Volume, 79, 147–153. doi:10.1302/0301-620X.79B1.6814

Brown, S. H. M., Gregory, D. E., & McGill, S. M. (2008). Vertebral end-plate fractures as a result of high rate pressure loading in the nucleus of the young adult porcine spine. Journal of Biomechanics, 41, 122–127. doi:10.1016/j.jbiomech.2007.07.005

Bryans, R., Decina, P., Descarreaux, M., Duranleau, M., Marcoux, H., Potter, B., … White, E. (2014). Evidence-based guidelines for the chiropractic treatment of adults with neck pain. Journal of Manipulative and Physiological Therapeutics, 37(1), 42–63. doi:10.1016/j.jmpt.2013.08.010

Brzecka, A. (2005). REM sleep behaviour disorder. Archives of Psychiatry and Psychotherapy. doi:10.1007/s10072-005-0485-7

Buckwalter, J. a. (1995). Aging and degeneration of the human intervertebral disc. Spine.

Bukata, S., Tomin, E., Pointon, A., Cunningham, M., & Lane, J. (2005). 11:4822. Spine fusion rate and mass volume is improved with administration of PTH 134 for six weeks. The Spine Journal, 5, S11–S12. doi:10.1016/j.spinee.2005.05.024

Bullough, P. G. (2004). The role of joint architecture in the etiology of arthritis. Osteoarthritis and Cartilage, 12, 2–9. doi:10.1016/j.joca.2003.09.010

Busse, J. W., Jacobs, C., Ngo, T., Rodine, R., Torrance, D., Jim, J., … Bhandari, M. (2009). Attitudes toward chiropractic: a survey of North American orthopedic surgeons. Spine, 34(25), 2818–2825. doi:10.1097/BRS.0b013e3181c1512f

Buttermann, G. R., & Beaubien, B. P. (2009). Biomechanical characterization of an annulus-sparing spinal disc prosthesis. Spine Journal, 9(9), 744–753. doi:10.1016/j.spinee.2009.04.026

Cagnie, B., Barbaix, E., Vinck, E., D’Herde, K., & Cambier, D. (2006). Atherosclerosis in the vertebral artery: An intrinsic risk factor in the use of spinal manipulation? Surgical and Radiologic Anatomy, 28, 129–134. doi:10.1007/s00276-005-0060-1

Caligaris, M., & Ateshian, G. a. (2008). Effects of sustained interstitial fluid pressurization under migrating contact area, and boundary lubrication by synovial fluid, on cartilage friction. Osteoarthritis and Cartilage, 16, 1220–1227. doi:10.1016/j.joca.2008.02.020

Callaghan, J. P., & McGill, S. M. (2001). Low back joint loading and kinematics during standing and unsupported sitting. Ergonomics, 44, 280–294. doi:10.1080/00140130118276

Campana, S., Charpail, E., de Guise, J. a., Rillardon, L., Skalli, W., & Mitton, D. (2011). Relationships between viscoelastic properties of lumbar intervertebral disc and degeneration grade assessed by MRI. Journal of the Mechanical Behavior of Biomedical Materials, 4(4), 593–599. doi:10.1016/j.jmbbm.2011.01.007

Cao, P., Kimura, S., Macias, B. R., Ueno, T., Watenpaugh, D. E., & Hargens, A. R. (2005). Exercise within lower body negative pressure partially counteracts lumbar spine deconditioning associated with 28-day bed rest. Journal of Applied Physiology (Bethesda, Md. : 1985), 99, 39–44. doi:10.1152/japplphysiol.01400.2004

Cardinale, M., & Wakeling, J. (2005). Whole body vibration exercise: are vibrations good for you? British Journal of Sports Medicine, 39, 585–589; discussion 589. doi:10.1136/bjsm.2005.016857

Carolina, N. (2011). NIH Public Access, 26(3), 371–386. doi:10.1016/j.cger.2010.03.002.Age-Related

Cascioli, V., Corr, P., & Till,  a. G. (2003). An investigation into the production of intra-articular gas bubbles and increase in joint space in the zygapophyseal joints of the cervical spine in asymptomatic subjects after spinal manipulation. Journal of Manipulative and Physiological Therapeutics, 26, 356–364. doi:10.1016/S0161-4754(03)00075-7

Casentini, G., Di Paola, L., Marrelli, L., & Palma, F. (2005). Rheological characterization of an artificial synovial fluid. International Journal of Artificial Organs.

Castellanos, J., & Axelrod, D. (1990). Effect of habitual knuckle cracking on hand function. Annals of the Rheumatic Diseases, 49(5), 308–9. Retrieved from

Cavanaugh, J. M., Lu, Y., Chen, C., & Kallakuri, S. (2006). Pain generation in lumbar and cervical facet joints. The Journal of Bone and Joint Surgery. American Volume, 88 Suppl 2, 63–67. doi:10.2106/JBJS.E.01411

Cerny, M., Marlois, R., Theumann, N., Bollmann, C., Wehrli, L., Richarme, D., … Becce, F. (2013). 3-T direct MR arthrography of the wrist: value of finger trap distraction to assess intrinsic ligament and triangular fibrocartilage complex tears. European Journal of Radiology, 82(10), e582–9. doi:10.1016/j.ejrad.2013.04.039

Chair care anti-creep. (n.d.).

Chan, D. D., & Khan, S. N. (2009). Study Design . Evaluation of degenerated intervertebral discs from a rabbit annular puncture. Spine, (November). doi:10.1097/BRS.0b013e3181f8be

Chan, S. C. W., Ferguson, S. J., & Gantenbein-Ritter, B. (2011). The effects of dynamic loading on the intervertebral disc. European Spine Journal, 20, 1796–1812. doi:10.1007/s00586-011-1827-1

Chan, W. C. W., Au, T. Y. K., Tam, V., Cheah, K. S. E., & Chan, D. (2014). Coming together is a beginning: The making of an intervertebral disc. Birth Defects Research Part C – Embryo Today: Reviews, 102(Ivd), 83–100. doi:10.1002/bdrc.21061

Chang, G., Kim, H. J., Kaplan, D., Vunjak-Novakovic, G., & Kandel, R. a. (2007). Porous silk scaffolds can be used for tissue engineering annulus fibrosus. European Spine Journal, 16, 1848–1857. doi:10.1007/s00586-007-0364-4

Chang, J.-Y., Shi, L.-H., Luo, F., Zhang, W.-M., & Woodward, D. J. (2007). Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson’s disease. Neuroscience and Biobehavioral Reviews, 31, 643–657. doi:10.1016/j.neubiorev.2007.01.002

Changes in Rem sleep percentage over the adult lifespan.pdf. (n.d.).

Chen, C., Tambe, D. T., Deng, L., & Yang, L. (2013). Biomechanical properties and mechanobiology of the articular chondrocyte. American Journal of Physiology. Cell Physiology, 305(12), C1202–8. doi:10.1152/ajpcell.00242.2013

Chen, J. H., Liu, C., You, L., & Simmons, C. a. (2010). Boning up on Wolff’s Law: Mechanical regulation of the cells that make and maintain bone. Journal of Biomechanics, 43(1), 108–118. doi:10.1016/j.jbiomech.2009.09.016

Chen, M.-H., Sun, J.-S., Liao, S.-Y., Tai, P.-A., Li, T.-C., & Chen, M.-H. (2015). Low-intensity pulsed ultrasound stimulates matrix metabolism of human annulus fibrosus cells mediated by transforming growth factor β1 and extracellular signal-regulated kinase pathway. Connective Tissue Research, 1–29. doi:10.3109/03008207.2015.1016609

Chen, S.-M., Liu, M.-F., Cook, J., Bass, S., & Lo, S. K. (2009). Sedentary lifestyle as a risk factor for low back pain: a systematic review. International Archives of Occupational and Environmental Health, 82, 797–806. doi:10.1007/s00420-009-0410-0

Chen, Y. L., Kuhi, T., & Israelachvili, J. (1992). Mechanism of cavitation damage in thin liquid films : collapse damage VS . inception damage, 153, 31–51.

Cheung, J. T. M., Zhang, M., & Chow, D. H. K. (2003). Biomechanical responses of the intervertebral joints to static and vibrational loading: A finite element study. Clinical Biomechanics, 18, 790–799. doi:10.1016/S0268-0033(03)00142-6

Chevrot,  a, & Vallee, C. (1992). Imaging of degenerative disk diseases. Current Opinion in Radiology, 4, 103–114. doi:10.1148/radiology.168.1.3289089

Chiang, C.-J., Cheng, C.-K., Sun, J.-S., Liao, C.-J., Wang, Y.-H., & Tsuang, Y.-H. (2011). The effect of a new anular repair after discectomy in intervertebral disc degeneration: an experimental study using a porcine spine model. Spine, 36(10), 761–769. doi:10.1097/BRS.0b013e3181e08f01

Chiu, E. J., Newitt, D. C., Segal, M. R., Hu, S. S., Lotz, J. C., & Majumdar, S. (2001). Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro. Spine, 26(19), E437–E444. doi:10.1097/00007632-200110010-00017

Chokshi, F. H., Quencer, R. M., & Smoker, W. R. K. (2010). The “thickened” ligamentum flavum: Is it buckling or enlargement? American Journal of Neuroradiology, 31, 1813–1816. doi:10.3174/ajnr.A2241

Chou, R., & Huffman, L. H. (2007). Clinical Guidelines Annals of Internal Medicine Nonpharmacologic Therapies for Acute and Chronic Low Back Pain : A Review of the Evidence for an American Pain Society / American College of Physicians Clinical Practice Guideline, 147, 492–504.

Christophy, M., Faruk Senan, N. A., Lotz, J. C., & O’Reilly, O. M. (2012). A Musculoskeletal model for the lumbar spine. Biomechanics and Modeling in Mechanobiology, 11(1989), 19–34. doi:10.1007/s10237-011-0290-6

Chuang, S.-Y., Popovich, J. M., Lin, L.-C., & Hedman, T. P. (2010). The effects of exogenous crosslinking on hydration and fluid flow in the intervertebral disc subjected to compressive creep loading and unloading. Spine, 35(24), E1362–E1366. doi:10.1097/BRS.0b013e3181e68695

Chung, S. S., Lee, C. S., & Kang, C. S. (2006). Lumbar total disc replacement using ProDisc II: a prospective study with a 2-year minimum follow-up. Journal of Spinal Disorders & Techniques, 19(6), 411–415. doi:10.1097/00024720-200608000-00007

City, U. (2001). A new , comprehensive normative database of lumbar spine ranges of motion, 2155(01), 371–379.

Clarke, E. C., Appleyard, R. C., & Bilston, L. E. (2007). Immature sheep spines are more flexible than mature spines: an in vitro biomechanical study. Spine, 32(26), 2970–2979. doi:10.1097/BRS.0b013e31815cde16

Claus, A., Hides, J., Moseley, G. L., & Hodges, P. (2008). Sitting versus standing: Does the intradiscal pressure cause disc degeneration or low back pain? Journal of Electromyography and Kinesiology, 18, 550–558. doi:10.1016/j.jelekin.2006.10.011

Clinical,  a R., Comparing, T., Giles, L. G. F., & Muller, R. (2003). Chronic Spinal Pain and Spinal Manipulation, 28(14), 1490–1503.

Cloward, R. B. (1959). Cervical Diskography:  A Contribution to the Etiology and Mechanism of Neck, Shoulder and Arm Pain*. Annals of Surgery, 150, 1052–1064. doi:10.1097/00000658-195912000-00013

Coleman, J. L., Widmyer, M. R., Leddy, H. a., Utturkar, G. M., Spritzer, C. E., Moorman, C. T., … DeFrate, L. E. (2013). Diurnal variations in articular cartilage thickness and strain in the human knee. Journal of Biomechanics, 46(3), 541–547. doi:10.1016/j.jbiomech.2012.09.013

Comella, C. L. (2007). Sleep disorders in Parkinson’s disease: An overview. Movement Disorders, 22(April). doi:10.1002/mds.21682

Conjoined_twins00429.pdf. (n.d.).

Costa, J., Henriques, R., Barroso, C., Ferreira, J., Atalaia,  a., & De Carvalho, M. (2006). Upper limb tremor induced by peripheral nerve injury. Neurology, 67(figure 2), 1884–1886. doi:10.1212/01.wnl.0000244437.31413.2b

Court, C., Chin, J. R., Liebenberg, E., Colliou, O. K., & Lotz, J. C. (2007). Biological and mechanical consequences of transient intervertebral disc bending. European Spine Journal, 16, 1899–1906. doi:10.1007/s00586-007-0476-x

Court, C., Colliou, O. K., Chin, J. R., Liebenberg, E., Bradford, D. S., & Lotz, J. C. (2001). The effect of static in vivo bending on the murine intervertebral disc. Spine Journal, 1, 239–245. doi:10.1016/S1529-9430(01)00056-0

Cracking Joints Revisited- a scientific explanation Anthony Unsworth* FREng (Durham University) and Duncan Dowson, CBE, FRS,FREng (Leeds University) *. (1971).

Cramer, G. D., Cambron, J., Cantu, J. a, Dexheimer, J. M., Pocius, J. D., Gregerson, D., … Grieve, T. J. (2013). Magnetic resonance imaging zygapophyseal joint space changes (gapping) in low back pain patients following spinal manipulation and side-posture positioning: a randomized controlled mechanisms trial with blinding. Journal of Manipulative and Physiological Therapeutics, 36(4), 203–17. doi:10.1016/j.jmpt.2013.04.003

Cramer, G. D., Gregerson, D. M., Knudsen, J. T., Hubbard, B. B., Ustas, L. M., & Cantu, J. A. (2002). The Effects of Side-Posture Positioning and Spinal Adjusting on the Lumbar Z Joints A Randomized Controlled Trial With Sixty-Four Subjects, 27(22), 2459–2466. doi:10.1097/01.BRS.0000031267.86149.E3

Cramer, G. D., Ross, K., Pocius, J., Cantu, J. a., Laptook, E., Fergus, M., … Raju, P. K. (2011). Evaluating the relationship among cavitation, zygapophyseal joint gapping, and spinal manipulation: An exploratory case series. Journal of Manipulative and Physiological Therapeutics, 34, 2–14. doi:10.1016/j.jmpt.2010.11.008

Cramer, G. D., Ross, K., Raju, P. K., Cambron, J., Cantu, J. a, Bora, P., … Gregerson, D. (n.d.). Quantification of cavitation and Gapping of. Journal of Manipulative and Physiological Therapeutics. doi:10.1016/j.jmpt.2012.06.007

Creep response of lumbar spine to prolonged flexion, McGill  1992  Abstract only. (n.d.).

Cronin, D. S. (2014). Finite element modeling of potential cervical spine pain sources in neutral position low speed rear impact. Journal of the Mechanical Behavior of Biomedical Materials, 33, 55–66. doi:10.1016/j.jmbbm.2013.01.006

Crosby, E. (1994). Postdural puncture headache. CMAJ: Canadian Medical Association Journal, 150, 821–823.

Cunningham, B. W., Hu, N., Beatson, H. J., Serhan, H., Sefter, J. C., & McAfee, P. C. (2009). Revision strategies for single- and two-level total disc arthroplasty procedures: a biomechanical perspective. Spine Journal, 9(9), 735–743. doi:10.1016/j.spinee.2009.03.011

Curtis, C. L., Rees, S. G., Little, C. B., Flannery, C. R., Hughes, C. E., Wilson, C., … Caterson, B. (2002). Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids. Arthritis and Rheumatism, 46(6), 1544–1553. doi:10.1002/art.10305

D’Anastasi, M., Birkenmaier, C., Schmidt, G. P., Wegener, B., Reiser, M. F., & Baur-Melnyk, A. (2011). Correlation between vacuum phenomenon on CT and fluid on MRI in degenerative disks. American Journal of Roentgenology, 197(November 2008), 1182–1189. doi:10.2214/AJR.10.6359

Daffner, S. D., Hymanson, H. J., & Wang, J. C. (2010). Cost and use of conservative management of lumbar disc herniation before surgical discectomy. Spine Journal, 10, 463–468. doi:10.1016/j.spinee.2010.02.005

Dahia, C. L., Mahoney, E. J., Durrani, A. a, & Wylie, C. (2009). Postnatal growth, differentiation, and aging of the mouse intervertebral disc. Spine, 34(5), 447–455. doi:10.1097/BRS.0b013e3181990c64

Dahl, M. C., Ahrens, M., Sherman, J. E., & Martz, E. O. (2010). The restoration of lumbar intervertebral disc load distribution: a comparison of three nucleus replacement technologies. Spine, 35(Xx), 1445–1453. doi:10.1097/BRS.0b013e3181bef192

Dalitz, K., & Vitzthum, H. E. (2008). Evaluation of five scoring systems for cervical spondylogenic myelopathy. Spine Journal. doi:10.1016/j.spinee.2008.05.005

Dang, L., & Liu, Z. (2010). A review of current treatment for lumbar disc herniation in children and adolescents. European Spine Journal, 19, 205–214. doi:10.1007/s00586-009-1202-7

Danielson, B., & Willén, J. (2001). Axially loaded magnetic resonance image of the lumbar spine in asymptomatic individuals. Spine, 26(23), 2601–2606. doi:10.1097/00007632-200112010-00015

Dankaerts, W., O’Sullivan, P., Burnett, A., & Straker, L. (2006). Differences in sitting postures are associated with nonspecific chronic low back pain disorders when patients are subclassified. Spine, 31(6), 698–704. doi:10.1097/01.brs.0000202532.76925.d2

Danziger, N., & Willer, J. C. (2005). Tension-type headache as the unique pain experience of a patient with congenital insensitivity to pain. Pain, 117, 478–483. doi:10.1016/j.pain.2005.07.012

Dar, G., Masharawi, Y., Peleg, S., Steinberg, N., May, H., Medlej, B., … Hershkovitz, I. (2011). The epiphyseal ring: a long forgotten anatomical structure with significant physiological function. Spine, 36(11), 850–856. doi:10.1097/BRS.0b013e3181e9b19d

DaSilva,  a F., Granziera, C., Snyder, J., & Hadjikhani, N. (2007). Thickening in the somatosensory cortex of patients with migraine. Neurology, 69, 1990–1995. doi:10.1212/01.wnl.0000291618.32247.2d

Dawm, V. D. W., E, S., Ii, R., C, A., Ap, V., M, L., … B, A. (2011). Physical examination for the diagnosis of lumbar radiculopathy due to disc herniation in patients with low-back pain and sciatica: a systematic review., (2). Retrieved from

de Peretti, F., Micalef, J. P., Bourgeon,  a., Argenson, C., & Rabischong, P. (1989). Biomechanics of the lumbar spinal nerve roots and the first sacral root within the intervertebral foramina. Surgical and Radiologic Anatomy, 11, 221–225. doi:10.1007/BF02337826

de Schepper, E. I. T., Damen, J., van Meurs, J. B. J., Ginai, A. Z., Popham, M., Hofman, A., … Bierma-Zeinstra, S. M. (2010). The association between lumbar disc degeneration and low back pain: the influence of age, gender, and individual radiographic features. Spine, 35(5), 531–536. doi:10.1097/BRS.0b013e3181aa5b33

DeLeo, J. a. (2006). Basic science of pain. The Journal of Bone and Joint Surgery. American Volume, 88 Suppl 2, 58–62. doi:10.2106/JBJS.E.01286

DePalma, M., Ketchum, J., Saullo, T., & Schofferman, J. (2011). Structural etiology of chronic low back pain due to motor vehicle collision. Pain Medicine (Malden, Mass.), 12(Mvc), 1622–7. doi:10.1111/j.1526-4637.2011.01246.x

Desrochers, J., Amrein, M. W., & Matyas, J. R. (2013). Microscale surface friction of articular cartilage in early osteoarthritis. Journal of the Mechanical Behavior of Biomedical Materials, 25, 11–22. doi:10.1016/j.jmbbm.2013.03.019

Details, C. (2006). OpenAIR @ RGU The Open Access Institutional Repository at Robert Gordon University. Access, 95, 58–63. Retrieved from

Deweber, K., Olszewski, M., & Ortolano, R. Knuckle cracking and hand osteoarthritis. Journal of the American Board of Family Medicine : JABFM, 24(2), 169–74. doi:10.3122/jabfm.2011.02.100156

Dheer, S., Zoga, A. C., & Morrison, W. B. (2011). Radiology Case Reports Clavicular avulsion of the costoclavicular ( rhomboid ) ligament : MRI findings, 6(4), 4–6. doi:10.2484/rcr.v6i4.579

Diamant, I., Shahar, R., Masharawi, Y., & Gefen,  a. (2007). A method for patient-specific evaluation of vertebral cancellous bone strength: In vitro validation. Clinical Biomechanics, 22, 282–291. doi:10.1016/j.clinbiomech.2006.10.005

Dimitriadis,  a T., Papagelopoulos, P. J., Smith, F. W., Mavrogenis,  a F., Pope, M. H., Karantanas,  a H., … Katonis, P. G. (2011). Intervertebral disc changes after 1 h of running: a study on athletes. The Journal of International Medical Research, 39, 569–579. doi:10.1177/147323001103900226

Dimitroulias,  a., Tsonidis, C., Natsis, K., Venizelos, I., Djau, S. N., Tsitsopoulos, P., & Tsitsopoulos, P. (2010). An immunohistochemical study of mechanoreceptors in lumbar spine intervertebral discs. Journal of Clinical Neuroscience, 17(6), 742–745. doi:10.1016/j.jocn.2009.09.032

Discogenic Origins of spinal instability, Zhao, SPine 2005. (n.d.).

Diurnal changes in stature effects of sleep deprivation in young and middle aged men.pdf. (n.d.).

Diurnal variations in intervertebral disc height a … [ Comput Methods Bio … (n.d.), 19937492.

Does the location of low back pain predict its source? Depalma MJ, Ketchum JM, Trussell BS, Saullo TR, Slipman CW. PM R 2011;3(1):33–9. (2011). The Spine Journal, 11, 577. doi:10.1016/j.spinee.2011.05.022

Dolan, P., Luo, J., Pollintine, P., Landham, P. R., Stefanakis, M., & Adams, M. a. (2013). Intervertebral disc decompression following endplate damage: implications for disc degeneration depend on spinal level and age. Spine, 38, 1473–81. doi:10.1097/BRS.0b013e318290f3cc

Doubleday, K. L., Kulig, K., & Landel, R. (2003). Treatment of Testicular Pain Using Conservative Management of the Thoracolumbar Spine: A Case Report. Archives of Physical Medicine and Rehabilitation, 84(12), 1903–1905. doi:10.1016/S0003-9993(03)00283-1

Dowzer, C. N., Reilly, T., & Cable, N. T. (1998). Effects of deep and shallow water running on spinal shrinkage. British Journal of Sports Medicine, 32, 44–48. doi:10.1136/bjsm.32.1.44

Drake, J. D. M., & Callaghan, J. P. (2009). Intervertebral neural foramina deformation due to two types of repetitive combined loading. Clinical Biomechanics, 24(1), 1–6. doi:10.1016/j.clinbiomech.2008.09.010

Drake, J. D. M., Dobson, H., & Callaghan, J. P. (2008). The influence of posture and loading on interfacet spacing: an investigation using magnetic resonance imaging on porcine spinal units. Spine, 33(20), E728–E734. doi:10.1097/BRS.0b013e318180e6a4

Dreischarf, M., Rohlmann, A., Bergmann, G., & Zander, T. (2011). Optimised loads for the simulation of axial rotation in the lumbar spine. Journal of Biomechanics, 44(12), 2323–2327. doi:10.1016/j.jbiomech.2011.05.040

Duncan, N. a. (2006). Cell deformation and micromechanical environment in the intervertebral disc. The Journal of Bone and Joint Surgery. American Volume, 88 Suppl 2, 47–51. doi:10.2106/JBJS.F.00035

Dzvonik, M. L., Kripke, D. F., Klauber, M., & Ancoli-Israel, S. (1986). Body position changes and periodic movements in sleep. Sleep, 9(April), 484–491.

Ebraheim, N. a, Lu, J., Haman, S. P., & Yeasting, R. a. (1998). Anatomic basis of the anterior surgery on the cervical spine: relationships between uncus-artery-root complex and vertebral artery injury. Surgical and Radiologic Anatomy : SRA, 20, 389–392. doi:10.1007/s00276-998-0389-3

Edgar, M. a. (2007). The nerve supply of the lumbar intervertebral disc. The Journal of Bone and Joint Surgery. British Volume, 89, 1135–1139. doi:10.1302/0301-620X.89B9.18939

Edwards, I. J., Lall, V. K., Paton, J. F., Yanagawa, Y., Szabo, G., Deuchars, S. a., & Deuchars, J. (2014). Neck muscle afferents influence oromotor and cardiorespiratory brainstem neural circuits. Brain Structure and Function, 1–16. doi:10.1007/s00429-014-0734-8

Effect of dynamic loading on the frictional response.pdf. (n.d.).

Eijkelkamp, M. F., Klein, J. P., Veldhuizen,  a G., Horn, J. R. Van, & Verkerke, G. J. (n.d.). Chapter 5 The geometry intervertebral disc and shape of the human. Spine, 75–84.



El-Rich, M., Shirazi-Adl, A., & Arjmand, N. (2004). Muscle activity, internal loads, and stability of the human spine in standing postures: combined model and in vivo studies. Spine, 29(23), 2633–2642. doi:10.1097/01.brs.0000146463.05288.0e

Email, Q., Panagiotis, G., Andrew, C., Joshua, I., Jack, M., James, W., … Jules, E. (2007a). Try OvidSP ! Clinical Neurophysiology, 17(19), 1–18.

Email, Q., Panagiotis, G., Andrew, C., Joshua, I., Jack, M., James, W., … Jules, E. (2007b). Try OvidSP ! Clinical Neurophysiology, 17(23), 1–18.


Emch, T. M., & Modic, M. T. (2011). Imaging of lumbar degenerative disk disease: History and current state. Skeletal Radiology, 40, 1175–1189. doi:10.1007/s00256-011-1163-x

Emrani, P. S., Katz, J. N., Kessler, C. L., Reichmann, W. M., Wright, E. a., McAlindon, T. E., & Losina, E. (2008). Joint space narrowing and Kellgren-Lawrence progression in knee osteoarthritis: an analytic literature synthesis. Osteoarthritis and Cartilage, 16, 873–882. doi:10.1016/j.joca.2007.12.004

Engel, R., & Bogduk, N. (1982). The menisci of the lumbar zygapophysial joints. Journal of Anatomy, 135(Pt 4), 795–809. Retrieved from

Engers,  a, Jellema, P., Wensing, M., van der Windt, D. a W. M., Grol, R., & van Tulder, M. W. (2008). Individual patient education for low back pain. Cochrane Database of Systematic Reviews (Online), (2), CD004057. doi:10.1002/14651858.CD004057.pub3

Errington, R. J., Puustjarvi, K., White, I. R., Roberts, S., & Urban, J. P. (1998). Characterisation of cytoplasm-filled processes in cells of the intervertebral disc. Journal of Anatomy, 192 ( Pt 3, 369–378. doi:10.1046/j.1469-7580.1998.19230369.x

Etchepare, F., Rozenberg, S., Mirault, T., Bonnet, A.-M., Lecorre, C., Agid, Y., … Fautrel, B. (2006). Back problems in Parkinson’s disease: an underestimated problem. Joint, Bone, Spine : Revue Du Rhumatisme, 73, 298–302. doi:10.1016/j.jbspin.2005.05.006

Evans, D. W. (2002). Mechanisms and effects of spinal high-velocity, low-amplitude thrust manipulation: Previous theories. Journal of Manipulative and Physiological Therapeutics, 25(4), 251–262. doi:10.1067/mmt.2002.123166

Fagan, A., Moore, R., Vernon Roberts, B., Blumbergs, P., & Fraser, R. (2003). ISSLS prize winner: The innervation of the intervertebral disc: a quantitative analysis. Spine, 28(23), 2570–2576. doi:10.1097/01.BRS.0000096942.29660.B1

Fardon, D. F., Williams, A. L., Dohring, E. J., Murtagh, F. R., Rothman, S. L. G., & Sze, G. (2014). Lumbar disc nomenclature : version 2 . 0. The Spine Journal, 14(11), 1–20. doi:10.1016/j.spinee.2014.04.022

Farrell, S. F., Osmotherly, P. G., Cornwall, J., & Rivett, D. A. (2014). The anatomy and morphometry of cervical zygapophyseal joint meniscoids. doi:10.1007/s00276-014-1406-3

Farshad-Amacker, N. a., Farshad, M., Winklehner, A., & Andreisek, G. (2015). MR- Imaging of degenerative disc disease. European Journal of Radiology. doi:10.1016/j.ejrad.2015.04.002

Farshad-Amacker, N. a., Hughes, A. P., Aichmair, A., Herzog, R. J., & Farshad, M. (2014). Is an annular tear a predictor for accelerated disc degeneration? European Spine Journal, 1–5. doi:10.1007/s00586-014-3260-8

Fazzalari, N. L., Parkinson, I. H., Fogg, Q. a, & Sutton-Smith, P. (2006). Antero-postero differences in cortical thickness and cortical porosity of T12 to L5 vertebral bodies. Joint, Bone, Spine : Revue Du Rhumatisme, 73, 293–297. doi:10.1016/j.jbspin.2005.03.023

Feng, H., Danfelter, M., Strömqvist, B., & Heinegård, D. (2006). Extracellular matrix in disc degeneration. The Journal of Bone and Joint Surgery. American Volume, 88 Suppl 2, 25–29. doi:10.2106/JBJS.E.01341

Ferguson, S. J., Ito, K., & Nolte, L. P. (2004). Fluid flow and convective transport of solutes within the intervertebral disc. Journal of Biomechanics. doi:10.1016/S0021-9290(03)00250-1

Fernando, H. N., Czamanski, J., Yuan, T.-Y., Gu, W., Salahadin, A., & Huang, C.-Y. C. (2011). Mechanical loading affects the energy metabolism of intervertebral disc cells. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 29, 1634–41. doi:10.1002/jor.21430

Ferreiro Perez, A., Garcia Isidro, M., Ayerbe, E., Castedo, J., & Jinkins, J. R. (2007). Evaluation of intervertebral disc herniation and hypermobile intersegmental instability in symptomatic adult patients undergoing recumbent and upright MRI of the cervical or lumbosacral spines. European Journal of Radiology, 62, 444–448. doi:10.1016/j.ejrad.2006.12.007

Ferrera, P. C., & Wheeling, H. M. (2000). Sternoclavicular joint injuries. The American Journal of Emergency Medicine, 18, 58–61.

Fields, A. J., Liebenberg, E. C., & Lotz, J. C. (2014). Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc. Spine Journal, 14, 513–521. doi:10.1016/j.spinee.2013.06.075

Fluid flow and convective transport of solutes within IVD.pdf. (n.d.).

Foley, L. M., Hitchens, T. K., Kochanek, P. M., Melick, J. a., Jackson, E. K., & Ho, C. (2005). Murine orthostatic response during prolonged vertical studies: Effect on cerebral blood flow measured by arterial spin-labeled MRI. Magnetic Resonance in Medicine, 54, 798–806. doi:10.1002/mrm.20621

Foolen, J., Van Donkelaar, C. C., & Ito, K. (2011). Intracellular tension in periosteum/perichondrium cells regulates long bone growth. Journal of Orthopaedic Research, 29(December 2009), 84–91. doi:10.1002/jor.21224

Fowler, T., & Sander, M. (2004). Published by the Residents and Faculty of the Department of Orthopaedics , The University of Iowa, 24.

Franke, O., Durst, K., Maier, V., Göken, M., Birkholz, T., Schneider, H., … Gelse, K. (2007). Mechanical properties of hyaline and repair cartilage studied by nanoindentation. Acta Biomaterialia, 3, 873–881. doi:10.1016/j.actbio.2007.04.005

Fredericson, M., Lee, S. U., Welsh, J., Butts, K., Norbash, A., & Carragee, E. J. (2001). Changes in posterior disc bulging and intervertebral foraminal size associated with flexion-extension movement: A comparison between L4-5 and L5-S1 levels in normal subjects. Spine Journal, 1, 10–17. doi:10.1016/S1529-9430(01)00014-6

Freeman, M. D., Centeno, C. J., & Kohles, S. S. (2009). A Systematic Approach to Clinical Determinations of Causation in Symptomatic Spinal Disk Injury Following Motor Vehicle Crash Trauma. PM and R, 1, 951–956. doi:10.1016/j.pmrj.2009.07.009

Freeman, M. D., Rosa, S., Harshfield, D., Smith, F., Bennett, R., Centeno, C. J., … Kohles, S. S. (2010). A case-control study of cerebellar tonsillar ectopia (Chiari) and head/neck trauma (whiplash). Brain Injury : [BI], 24(July), 988–994. doi:10.3109/02699052.2010.490512

Freemont,  a J., Watkins,  a, Le Maitre, C., Baird, P., Jeziorska, M., Knight, M. T. N., … Hoyland, J. a. (2002). Nerve growth factor expression and innervation of the painful intervertebral disc. The Journal of Pathology, 197(March), 286–292. doi:10.1002/path.1108

Freemont,  a. J., Peacock, T. E., Goupille, P., Hoyland, J. a., O’Brien, J., & Jayson, M. I. V. (1997). Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet, 350, 178–181. doi:10.1016/S0140-6736(97)02135-1

Friedl, G., Schmidt, H., Rehak, I., Kostner, G., Schauenstein, K., & Windhager, R. (2007). Undifferentiated human mesenchymal stem cells (hMSCs) are highly sensitive to mechanical strain: transcriptionally controlled early osteo-chondrogenic response in vitro. Osteoarthritis and Cartilage, 15, 1293–1300. doi:10.1016/j.joca.2007.04.002

Friedrich, K. M., Reiter, G., Pretterklieber, M. L., Pinker, K., Friedrich, M., Trattnig, S., & Salomonowitz, E. (2008). Reference Data for In Vivo Magnetic Resonance Imaging Properties of Meniscoids in the Cervical Zygapophyseal Joints, 33(21), 778–783.

Friedrich, K. M., Trattnig, S., Millington, S. a, Friedrich, M., Groschmidt, K., & Pretterklieber, M. L. (2007). High-field magnetic resonance imaging of meniscoids in the zygapophyseal joints of the human cervical spine. Spine, 32(2), 244–8. doi:10.1097/01.brs.0000251952.36735.fb

Fritzell, P. (2006). Comments on “health economic evaluation in lumbar spinal fusion. A systematic literature review anno 2005.” European Spine Journal, 15, 1174–1175. doi:10.1007/s00586-005-0060-1

Frobin, W., Brinckmann, P., Biomechanik, E., Munster, U., Klinik, R., Bethesda, E. K., … Burton, K. (1997). A journal affiliated to the International Society of Biomechanics and the American Society of Biomechanics Volume 12 Supplement Number 1 PRECISON MEASUREMENT OF DISC HEIGHT . VERTEBRAL HEIGHT AND SAGITTAL PLANE DISPLACEMENT FROM LATERAL RADIOGRAPHIC VIEWS (Vol. 12).

Frobin, W., Brinckmann, P., Kramer, M., & Hartwig, E. (2001). Height of lumbar discs measured from radiographs compared with degeneration and height classified from MR images. European Radiology, 11, 263–269. doi:10.1007/s003300000556

Frobin, W., Leivseth, G., Biggemann, M., & Brinckmann, P. (2002). Vertebral height, disc height, posteroanterior displacement and dens-atlas gap in the cervical spine: Precision measurement protocol and normal data. Clinical Biomechanics, 17, 423–431. doi:10.1016/S0268-0033(02)00044-X

Fryer, J. (2014). Hypnic Reflex: A Spinal Perspective. Journal of Sleep Disorders & Therapy, 03(05), 277–279. doi:10.4172/2167-0277.1000177

Fryer, J. C. (2009). Is a purpose of REM sleep atonia to help regenerate intervertebral disc volumetric loss? Journal of Circadian Rhythms, 7, 1. doi:10.1186/1740-3391-7-1

Fryer, J. C. J., Quon, J. a., & Smith, F. W. (2010). Magnetic resonance imaging and stadiometric assessment of the lumbar discs after sitting and chair-care decompression exercise: a pilot study. Spine Journal, 10(4), 297–305. doi:10.1016/j.spinee.2010.01.009

Fryer, J., & Zhang, W. (2010). Preliminary investigation into a seated unloading movement strategy for the lumbar spine: A pilot study. Journal of Bodywork and Movement Therapies, 14(2), 119–126. doi:10.1016/j.jbmt.2008.06.008

Fujimoto, K., Miyagi, M., Ishikawa, T., Inoue, G., Eguchi, Y., Kamoda, H., … Ohtori, S. (2012). Sensory and Autonomic Innervation of the Cervical Intervertebral Disc in Rats. Spine, 37(16), 1357–1362. doi:10.1097/BRS.0b013e31824ba710

Fujiwara, A., Tamai, K., An, H. S., Kurihashi, T., Lim, T. H., Yoshida, H., & Saotome, K. (2000). The relationship between disc degeneration, facet joint osteoarthritis, and stability of the degenerative lumbar spine. Journal of Spinal Disorders, 13(5), 444–50. Retrieved from

Galbusera, F., Schmidt, H., Neidlinger-Wilke, C., Gottschalk, A., & Wilke, H. J. (2011). The mechanical response of the lumbar spine to different combinations of disc degenerative changes investigated using randomized poroelastic finite element models. European Spine Journal, 20, 563–571. doi:10.1007/s00586-010-1586-4

Galbusera, F., Van Rijsbergen, M., Ito, K., Huyghe, J. M., Brayda-Bruno, M., & Wilke, H. J. (2014). Ageing and degenerative changes of the intervertebral disc and their impact on spinal flexibility. European Spine Journal, 23. doi:10.1007/s00586-014-3203-4

Gawri, R., Rosenzweig, D. H., Krock, E., Ouellet, J. a, Stone, L. S., Quinn, T. M., & Haglund, L. (2014). High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain. Arthritis Research & Therapy, 16, R21. doi:10.1186/ar4449

Gay, R. E., Ilharreborde, B., Zhao, K. D., Berglund, L. J., Bronfort, G., & An, K. N. (2008). Stress in lumbar intervertebral discs during distraction: a cadaveric study. Spine Journal, 8, 982–990. doi:10.1016/j.spinee.2007.07.398

Gebremariam, L., Koes, B. W., Peul, W. C., & Huisstede, B. M. (2012). Evaluation of Treatment Effectiveness for the Herniated Cervical Disc. Spine, 37, E109–E118. doi:10.1097/BRS.0b013e318221b5af

Gentile, S., Lo Giudice, R., De Martino, P., Rainero, I., & Pinessi, L. (2004). Headache attributed to spontaneous low CSF pressure: Report of three cases responsive to corticosteroids. European Journal of Neurology, 11, 849–851. doi:10.1111/j.1468-1331.2004.00898.x

Gilbert, J. W., Wheeler, G. R., Kreft, M. P., Upadhyay, S. P., Storey, B. B., Spitalieri, J. R., … Gibbs, R. a. (2008). Repeat Upright Positional Magnetic Resonance Imaging for Diagnosis of Disorders Underlying Chronic Noncancer Lumbar Pain. Journal of Manipulative and Physiological Therapeutics. doi:10.1016/j.jmpt.2008.09.005

Gilbert, K. K., Brismée, J.-M., Collins, D. L., James, C. R., Shah, R. V, Sawyer, S. F., & Sizer, P. S. (2007). 2006 Young Investigator Award Winner: lumbosacral nerve root displacement and strain: part 2. A comparison of 2 straight leg raise conditions in unembalmed cadavers. Spine, 32(14), 1521–1525. doi:10.1097/BRS.0b013e318067dd55

Giles, L. G. F., & Muller, R. (2003). Chronic Spinal Pain : A Randomized Clinical Trial Comparing Medication , Acupuncture , and Spinal Manipulation Spine July 15 , 2003 ; 28 ( 14 ): 1490-1502, 28(14), 1–6.

Gisolf, J., van Lieshout, J. J., van Heusden, K., Pott, F., Stok, W. J., & Karemaker, J. M. (2004). Human cerebral venous outflow pathway depends on posture and central venous pressure. The Journal of Physiology, 560, 317–327. doi:10.1113/jphysiol.2004.070409

Gleghorn, J. P., Doty, S. B., Warren, R. F., Wright, T. M., Maher, S. a., & Bonassar, L. J. (2010). Analysis of frictional behavior and changes in morphology resulting from cartilage articulation with porous polyurethane foams. Journal of Orthopaedic Research, 28(October), 1292–1299. doi:10.1002/jor.21136

Godefroy, J., & Jones, J. C. (2002). A reappraisal of the flash point of formic acid. Journal of Loss Prevention in the Process Industries, 15(15), 241–243. doi:10.1016/S0950-4230(01)00063-8

Goel, V. K., & Clausen, J. D. (1998). Prediction of load sharing among spinal components of a C5-C6 motion segment using the finite element approach. Spine, 23, 684–691. doi:10.1097/00007632-199803150-00008

Gohil, I., Vilensky, J. a, & Weber, E. C. (2014a). Vacuum phenomenon: Clinical relevance. Clinical Anatomy (New York, N.Y.), 27(3), 455–62. doi:10.1002/ca.22334

Gohil, I., Vilensky, J. a, & Weber, E. C. (2014b, April). Vacuum phenomenon: Clinical relevance. Clinical Anatomy (New York, N.Y.). doi:10.1002/ca.22334

Goldring, M. B. (2009). The link between structural damage and pain in a genetic model of osteoarthritis and intervertebral disc degeneration: A joint misadventure. Arthritis and Rheumatism, 60(9), 2550–2552. doi:10.1002/art.24771

Gorman, K. F., & Breden, F. (2009). Idiopathic-type scoliosis is not exclusive to bipedalism. Medical Hypotheses, 72, 348–352. doi:10.1016/j.mehy.2008.09.052

Granata, K. P. (2006). Response to “Static and dynamic stability of the spine.” Journal of Biomechanics, 39, 2921–2922. doi:10.1016/j.jbiomech.2006.07.015

Greaves, C. Y., Gadala, M. S., & Oxland, T. R. (2008). A three-dimensional finite element model of the cervical spine with spinal cord: An investigation of three injury mechanisms. Annals of Biomedical Engineering, 36(3), 396–405. doi:10.1007/s10439-008-9440-0

Griffith, J. F., Wang, Y.-X. J., Antonio, G. E., Choi, K. C., Yu, A., Ahuja, A. T., & Leung, P. C. (2007). Modified Pfirrmann grading system for lumbar intervertebral disc degeneration. Spine, 32(24), E708–E712. doi:10.1097/BRS.0b013e31815a59a0

Groen, R. J. M., Grobbelaar, M., Muller, C. J. F., Van Solinge, G., Verhoof, O., Du Toit, D. F., & Hoogland, P. V. J. M. (2005). Morphology of the human internal vertebral venous plexus: A cadaver study after latex injection in the 21-25-week fetus. Clinical Anatomy, 18(January), 397–403. doi:10.1002/ca.20153

Grooten, W. J. A., Mulder, M., Josephson, M., Alfredsson, L., & Wiktorin, C. (2007). The influence of work-related exposures on the prognosis of neck/shoulder pain. European Spine Journal, 16, 2083–2091. doi:10.1007/s00586-007-0481-0

Gruber, H. E., Ashraf, N., Kilburn, J., Williams, C., Norton, H. J., Gordon, B. E., & Hanley, E. N. (2005). Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat. Spine, 30(23), 2593–2600. doi:10.1097/01.brs.0000187877.30149.83

Gruber, H. E., Gordon, B., Williams, C., Norton, H. J., & Hanley, E. N. (2007). Vertebral endplate and disc changes in the aging sand rat lumbar spine: cross-sectional analyses of a large male and female population. Spine, 32(23), 2529–2536. doi:10.1097/BRS.0b013e318158cd69

Gruber, H. E., Ingram, J. a., Davis, D. E., & Hanley, E. N. (2009). Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus. Spine Journal, 9, 210–215. doi:10.1016/j.spinee.2008.01.012

Grunhagen, T., Wilde, G., Soukane, D. M., Shirazi-Adl, S. a, & Urban, J. P. G. (2006). Nutrient supply and intervertebral disc metabolism. The Journal of Bone and Joint Surgery. American Volume, 88 Suppl 2, 30–35. doi:10.2106/JBJS.E.01290

Guehring, T., Nerlich, A., Kroeber, M., Richter, W., & Omlor, G. W. (2010). Sensitivity of notochordal disc cells to mechanical loading: An experimental animal study. European Spine Journal, 19, 113–121. doi:10.1007/s00586-009-1217-0

Guehring, T., Omlor, G. W., Lorenz, H., Engelleiter, K., Richter, W., Carstens, C., & Kroeber, M. (2006). Disc distraction shows evidence of regenerative potential in degenerated intervertebral discs as evaluated by protein expression, magnetic resonance imaging, and messenger ribonucleic acid expression analysis. Spine, 31(15), 1658–1665. doi:10.1097/01.brs.0000224558.81765.56

Guehring, T., Unglaub, F., Lorenz, H., Omlor, G., Wilke, H. J., & Kroeber, M. W. (2006). Intradiscal pressure measurements in normal discs, compressed discs and compressed discs treated with axial posterior disc distraction: An experimental study on the rabbit lumbar spine model. European Spine Journal, 15, 597–604. doi:10.1007/s00586-005-0953-z

Guiot, B. H., & Fessler, R. G. (2000). Molecular biology of degenerative disc disease. Neurosurgery, 47(5), 1034–1040.

Gullbrand, S. E., Peterson, J., Ahlborn, J., Mastropolo, R., Fricker, A., Roberts, T. T., … Ledet, E. H. (2015). ISSLS Prize Winner. Spine, 40(15), 1158–1164. doi:10.1097/BRS.0000000000001012

Gumina, S., Carbone, S., Albino, P., Gurzi, M., & Postacchini, F. (2013). Arm Squeeze Test: a new clinical test to distinguish neck from shoulder pain. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 22, 1558–63. doi:10.1007/s00586-013-2788-3

Güvençer, M., Naderi, S., Kiray, A., Yilmaz, H. S., & Tetik, S. (2008). The relation between the lumbar vertebrae and the spinal nerves for far lateral lumbar spinal approaches. Journal of Clinical Neuroscience, 15, 192–197. doi:10.1016/j.jocn.2006.12.001

Haas, M., Vavrek, D., Peterson, D., & Et Al. (2014). Dose-response and efficacy of spinal manipulation for care of chronic low back pain: a randomized controlled trial. The Spine Journal : Official Journal of the North American Spine Society, 14(7), 1106–16. doi:10.1016/j.spinee.2013.07.468

Haden, N., Latimer, M., Seeley, H. M., & Laing, R. J. (2005). Loss of inter-vertebral disc height after anterior cervical discectomy. British Journal of Neurosurgery, 19(December), 469–474. doi:10.1080/02688690500495109

Hallett, M. (2008). The intrinsic and extrinsic aspects of freezing of gait. Movement Disorders, 23. doi:10.1002/mds.21836

Hamamoto, Y., Ogata, T., Morino, T., Hino, M., & Yamamoto, H. (2007). Real-time direct measurement of spinal cord blood flow at the site of compression: relationship between blood flow recovery and motor deficiency in spinal cord injury. Spine, 32(18), 1955–1962. doi:10.1097/BRS.0b013e3181316310

Hammer, M. (2002). Discogenic pain. Agri, 14, 7–16. doi:10.1016/j.pain.2004.08.016

Hampel, G. a., & Chang, W. R. (1999). Body height change from motor vehicle vibration. International Journal of Industrial Ergonomics, 23(June 1997), 489–498. doi:10.1016/S0169-8141(98)00008-0

Han, K. S., Zander, T., Taylor, W. R., & Rohlmann, A. (2012). An enhanced and validated generic thoraco-lumbar spine model for prediction of muscle forces. Medical Engineering and Physics, 34, 709–716. doi:10.1016/j.medengphy.2011.09.014

Hancock, M. J., Maher, C. G., Latimer, J., Spindler, M. F., McAuley, J. H., Laslett, M., & Bogduk, N. (2007). Systematic review of tests to identify the disc, SIJ or facet joint as the source of low back pain. European Spine Journal, 16, 1539–1550. doi:10.1007/s00586-007-0391-1

Hangai, M., Kaneoka, K., Kuno, S., Hinotsu, S., Sakane, M., Mamizuka, N., … Ochiai, N. (2007). Factors associated with lumbar intervertebral disc degeneration in the elderly. The Spine Journal : Official Journal of the North American Spine Society, 8, 732–740. doi:10.1016/j.spinee.2007.07.392

Hannon, J. C. (2005). A review of Aston Patterning?? Journal of Bodywork and Movement Therapies, 9, 260–269. doi:10.1016/j.jbmt.2005.08.004

Harada, Y., Tomita, N., Nakajima, M., Ikeuchi, K., & Wakitani, S. (2005). Effect of low loading and joint immobilization for spontaneous repair of osteochondral defect in the knees of weightless (tail suspension) rats. Journal of Orthopaedic Science, 10, 508–514. doi:10.1007/s00776-005-0931-7

Hargrove Manipulation.pdf. (n.d.).

Harrison, D. D., Harrison, S. O., Croft,  a C., Harrison, D. E., & Troyanovich, S. J. (1999). Sitting biomechanics part I: review of the literature. Journal of Manipulative and Physiological Therapeutics, 22(9), 594–609. doi:10.1016/S0161-4754(99)70020-5

Hartman, J. (2014). Anatomy and clinical significance of the uncinate process and uncovertebral joint: A comprehensive review. Clinical Anatomy (New York, N.Y.), 27(3), 431–40. doi:10.1002/ca.22317

Haschtmann, D., Stoyanov, J. V., Gédet, P., & Ferguson, S. J. (2008). Vertebral endplate trauma induces disc cell apoptosis and promotes organ degeneration in vitro. European Spine Journal, 17, 289–299. doi:10.1007/s00586-007-0509-5

Hauck, E. F., Wittkowski, W., & Bothe, H. W. (2008). Intradural microanatomy of the nerve roots S1-S5 at their origin from the conus medullaris. Journal of Neurosurgery. Spine, 9(2), 207–212. doi:10.3171/SPI/2008/9/8/207

Haughton, V. (2004). Medical imaging of intervertebral disc degeneration: current status of imaging. Spine, 29(23), 2751–2756. doi:10.1097/01.brs.0000148475.04738.73

Haughton, V. (2006). Imaging intervertebral disc degeneration. The Journal of Bone & Joint Surgery, 88, 15–21. Retrieved from

Haughton, V. M. (2011). The “dehydrated” lumbar intervertebral disk on MR, its anatomy biochemistry and biomechanics. Neuroradiology Journal, 24, 564–569. doi:10.1007/s00234-011-0923-6

Hausfater, G. (1975). Knuckle walking by a baboon (Papio cynocephalus). American Journal of Physical Anthropology, 43, 303–306. doi:10.1002/ajpa.1330430217

Healey, E. L., Burden,  a. M., McEwan, I. M., & Fowler, N. E. (2008). Stature loss and recovery following a period of loading: Effect of time of day and presence or absence of low back pain. Clinical Biomechanics, 23, 721–726. doi:10.1016/j.clinbiomech.2008.02.011

Hee, H. T., Chuah, Y. J., Tan, B. H. M., Setiobudi, T., & Wong, H. K. (2011). Vascularization and morphological changes of the endplate after axial compression and distraction of the intervertebral disc. Spine, 36(Xx), 505–511. doi:10.1097/BRS.0b013e3181d32410

Hee, H. T., Zhang, J., & Wong, H. K. (2010). An in vitro study of dynamic cyclic compressive stress on human inner annulus fibrosus and nucleus pulposus cells. Spine Journal, 10, 795–801. doi:10.1016/j.spinee.2010.06.009

Heiner, A. D. (2008). Structural properties of fourth-generation composite femurs and tibias. Journal of Biomechanics, 41, 3282–3284. doi:10.1016/j.jbiomech.2008.08.013

Henderson, C. N. R. (2012). The basis for spinal manipulation: Chiropractic perspective of indications and theory. Journal of Electromyography and Kinesiology, 22(5), 632–642. doi:10.1016/j.jelekin.2012.03.008

Heneghan, P., & Riches, P. E. (2008a). Determination of the strain-dependent hydraulic permeability of the compressed bovine nucleus pulposus. Journal of Biomechanics, 41, 903–906. doi:10.1016/j.jbiomech.2007.11.014

Heneghan, P., & Riches, P. E. (2008b). The strain-dependent osmotic pressure and stiffness of the bovine nucleus pulposus apportioned into ionic and non-ionic contributors. Journal of Biomechanics, 41, 2411–2416. doi:10.1016/j.jbiomech.2008.05.025

Henschke, N., Maher, C. G., & Refshauge, K. M. (2007). Screening for malignancy in low back pain patients: A systematic review. European Spine Journal, 16, 1673–1679. doi:10.1007/s00586-007-0412-0

Herzog, W. (n.d.). The physics of spinal manipulation. Journal of Manipulative and Physiological Therapeutics.

Herzog, W. (2010). The biomechanics of spinal manipulation. Journal of Bodywork and Movement Therapies, 14(3), 280–286. doi:10.1016/j.jbmt.2010.03.004

Heuer, F., Schmidt, H., & Wilke, H. J. (2008). The relation between intervertebral disc bulging and annular fiber associated strains for simple and complex loading. Journal of Biomechanics, 41(1978), 1086–1094. doi:10.1016/j.jbiomech.2007.11.019

Heuer, F., Schmitt, H., Schmidt, H., Claes, L., & Wilke, H. J. (2007). Creep associated changes in intervertebral disc bulging obtained with a laser scanning device. Clinical Biomechanics, 22, 737–744. doi:10.1016/j.clinbiomech.2007.04.010

Hida, K., Ph, D., Yano, S., & Iwasaki, Y. (2008). Considerations in the Treatment of Cervical Ossification of the Posterior Longitudinal Ligament, 55, 126–132.

Hirasawa, Y., Bashir, W. a, Smith, F. W., Magnusson, M. L., Pope, M. H., & Takahashi, K. (2007). Postural changes of the dural sac in the lumbar spines of asymptomatic individuals using positional stand-up magnetic resonance imaging. Spine, 32(4), E136–E140. doi:10.1097/

Hirata, H., Yurube, T., Kakutani, K., Maeno, K., Takada, T., Yamamoto, J., … Nishida, K. (2014). A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype. Journal of Orthopaedic Research, 32, 455–463. doi:10.1002/jor.22533

Holguin, N., Muir, J., Rubin, C., & Judex, S. (2009). Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest. Spine Journal, 9, 470–477. doi:10.1016/j.spinee.2009.02.009

Holtzman, G. (2011). Clinical Examination Procedures to Determine the Effect of Axial Decompression on Low Back Pain Symptoms in People With Chronic Low Back Pain. Journal of Orthopaedic and Sports Physical Therapy, 42(2), 105–113. doi:10.2519/jospt.2012.3724

Hopkins, J. (2006). Could high blood pressure be causing your headache?, (January).

Horiguchi, T., & Takeshita, K. (2003). Neuropsychological developmental change in a case with Noonan syndrome: longitudinal assessment. Brain & Development, 25, 291–293. doi:10.1016/S0

Horner, H. a, & Urban, J. P. (2001). 2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine, 26(23), 2543–2549. doi:10.1097/00007632-200112010-00006

Hou, Y., & Luo, Z. (2009). A study on the structural properties of the lumbar endplate: histological structure, the effect of bone density, and spinal level. Spine, 34(12), E427–E433. doi:10.1097/BRS.0b013e3181a2ea0a

Hu, J., Morishita, Y., Montgomery, S., Hymanson, H., Taghavi, C., Do, D., & Wang, J. (2011). Kinematic Evaluation of Association between Disc Bulge Migration, Lumbar Segmental Mobility, and Disc Degeneration in the Lumbar Spine Using Positional Magnetic Resonance Imaging. Global Spine Journal, 1, 043–048. doi:10.1055/s-0031-1296056

Huang, C. Y., & Gu, W. Y. (2008). Effects of mechanical compression on metabolism and distribution of oxygen and lactate in intervertebral disc. Journal of Biomechanics, 41, 1184–1196. doi:10.1016/j.jbiomech.2008.02.002

Huang, C.-Y. C., Yuan, T.-Y., Jackson, A. R., Hazbun, L., Fraker, C., & Gu, W. Y. (2007). Effects of low glucose concentrations on oxygen consumption rates of intervertebral disc cells. Spine, 32(19), 2063–2069. doi:10.1097/BRS.0b013e318145a521

Huang, K. Y., Lin, R. M., Lee, Y. L., & Li, J. D. (2009). Factors affecting disability and physical function in degenerative lumbar spondylolisthesis of L4-5: Evaluation with axially loaded MRI. European Spine Journal, 18, 1851–1857. doi:10.1007/s00586-009-1059-9

Huber, G., Morlock, M. M., & Ito, K. (2007). Consistent hydration of intervertebral discs during in vitro testing. Medical Engineering and Physics, 29, 808–813. doi:10.1016/j.medengphy.2006.09.001

Hui, A. Y., & Mccarty, W. J. (2013). NIH Public Access. doi:10.1002/wsbm.157.A

Hung, W.-C., Chang, C.-H., Hsu, A.-T., & Lin, H.-T. (2013). the Role of Negative Intra-Articular Pressure in Stabilizing the Metacarpophalangeal Joint. Journal of Mechanics in Medicine and Biology, 13(02), 1350049. doi:10.1142/S0219519413500498

Hunter, D. J., Zhang, Y. Q., Tu, X., LaValley, M., Niu, J. B., Amin, S., … Felson, D. T. (2006). Change in joint space width: Hyaline articular cartilage loss or alteration in meniscus? Arthritis and Rheumatism, 54(8), 2488–2495. doi:10.1002/art.22016

Hussain, M., Natarajan, R. N., Chaudhary, G., An, H. S., & Andersson, G. B. (2011). Simulation of inhomogeneous rather than homogeneous poroelastic tissue material properties within disc annulus and nucleus better predicts cervical spine response: a C3-T1 finite element model analysis under compression and moment loadings. Spine, 36(4), E245–E255. doi:10.1097/BRS.0b013e3181f2af72

Hutton, W. C., Malko, J. a., & Fajman, W. a. (2003). Lumbar disc volume measured by MRI: Effects of bed rest, horizontal exercise, and vertical loading. Aviation Space and Environmental Medicine, 74(1), 73–78.

Hutton, W. C., Toribatake, Y., Elmer, W. a, Ganey, T. M., Tomita, K., & Whitesides, T. E. (1998). The effect of compressive force applied to the intervertebral disc in vivo. A study of proteoglycans and collagen. Spine, 23(23), 2524–2537. doi:10.1097/00007632-199812010-00007

Huynh, C. N., Yanni, L. M., & Morgan, L. a. (2007). Key practice points in the management of fibromyalgia. American Family Physician, 76, 195.

Hyperextension and Spine Height Changes 20 minutes recovery. (n.d.).

Ianuzzi, A., Pickar, J. G., & Khalsa, P. S. (2009). Determination of torque-limits for human and cat lumbar spine specimens during displacement-controlled physiological motions. Spine Journal, 9, 77–86. doi:10.1016/j.spinee.2007.07.391

Iatridis, J. C., Laible, J. P., & Krag, M. H. (2003). Influence of fixed charge density magnitude and distribution on the intervertebral disc: applications of a poroelastic and chemical electric (PEACE) model. Journal of Biomechanical Engineering. doi:10.1115/1.1537190

Iatridis, J. C., MacLean, J. J., Roughley, P. J., & Alini, M. (2006). Effects of mechanical loading on intervertebral disc metabolism in vivo. The Journal of Bone and Joint Surgery. American Volume, 88 Suppl 2, 41–46. doi:10.2106/JBJS.E.01407

Iatridis, J. C., Nicoll, S. B., Michalek, A. J., Walter, B. a., & Gupta, M. S. (2013). Role of biomechanics in intervertebral disc degeneration and regenerative therapies: What needs repairing in the disc and what are promising biomaterials for its repair? Spine Journal, 13, 243–262. doi:10.1016/j.spinee.2012.12.002

Ibt, X., Boe, T. N., Mbzfst, E., Ujttvf, P. G., & Wbszjoh, X. (2007). Osteoarthritis and Cartilage Vol. 15, Supplement B Extended Abstracts B35 17.1, 15, 2007.

Igic, I., Ryser, S., & Elfering, A. (2013). Does work stress make you shorter? An ambulatory field study of daily work stressors, job control, and spinal shrinkage. Journal of Occupational Health Psychology, 18(4), 469–80. doi:10.1037/a0034256

Iguchi, T., Ozaki, T., Chin, T., Tsumura, N., Kanemura, A., Kasahara, K., … Nishida, K. (2011). Intimate relationship between instability and degenerative signs at L4/5 segment examined by flexion-extension radiography. European Spine Journal, 20, 1349–1354. doi:10.1007/s00586-011-1793-7

Ikels, K. G. (1970). Production of gas bubbles in fluids by tribonucleation. J Appl Physiol, 28(4), 524–527. Retrieved from

Illien-Jünger, S., Gantenbein-Ritter, B., Grad, S., Lezuo, P., Ferguson, S. J., Alini, M., & Ito, K. (2010). The combined effects of limited nutrition and high-frequency loading on intervertebral discs with endplates. Spine, 35(3100), 1744–1752. doi:10.1097/BRS.0b013e3181c48019

Imagama, S., Hasegawa, Y., Seki, T., Matsuyama, Y., Sakai, Y., Ito, Z., … Suzuki, K. (2011). The Effect of β-Carotene on Lumbar Osteophyte Formation. Spine, 36, 2293–2298. doi:10.1097/BRS.0b013e3182254a18

Imaging of lumbar degenerative disk disease T Modic. (n.d.).

Imai, Y., Okuma, M., An, H. S., Nakagawa, K., Yamada, M., Muehleman, C., … Masuda, K. (2007). Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC. Spine, 32(11), 1197–1205. doi:10.1097/BRS.0b013e3180574d26

In vivi diurnal variation Botsford.pdf. (n.d.).

Inami, S., Shiga, T., Tsujino, A., Yabuki, T., Okado, N., & Ochiai, N. (2001). Immunohistochemical demonstration of nerve fibers in the synovial fold of the human cervical facet joint. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 19(4), 593–6. doi:10.1016/S0736-0266(00)00048-6

Indahl,  a, Haldorsen, E. H., Holm, S., Reikerås, O., & Ursin, H. (1998). Five-year follow-up study of a controlled clinical trial using light mobilization and an informative approach to low back pain. Spine, 23(23), 2625–2630.

Integration of Laser Therapy into Chiropractic Practice final. (n.d.).

Intervertbral Disc Anatomy Physiology Pathophysiology and Treatment  REVIEW 2008.pdf. (n.d.).

Investigations, E. (1985). Rheumdo!ogy, 241–245.

Iranzo, A., Molinuevo, J. L., Santamaría, J., Serradell, M., Martí, M. J., Valldeoriola, F., & Tolosa, E. (2006). Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurology, 5(July), 572–577. doi:10.1016/S1474-4422(06)70476-8

Izci, Y., Gürkanlar, D., Ozan, H., & Gönül, E. (2005). Lomber pleksus ve köklerin morfolojik özellikleri. Anatomik çalişma. Turkish Neurosurgery, 15, 87–92.

Jackson, A. R., Yuan, T. Y., Huang, C. Y., & Gu, W. Y. (2009). A conductivity approach to measuring fixed charge density in intervertebral disc tissue. Annals of Biomedical Engineering, 37, 2566–2573. doi:10.1007/s10439-009-9792-0

JAMA article January 2009 Chiari Conundrum (2). (n.d.).

Jarman, J. P., Emre, V., Baruah, D., & Klein, A. P. (2014). Accurate measurement of intervertebral disc height loss demonstrates the threshold of major pathological changes during the, 36, 4833. doi:10.1007/s00586-014-3564-8

Jensen, T. S., Karppinen, J., Sorensen, J. S., Niinimäki, J., & Leboeuf-Yde, C. (2008). Vertebral endplate signal changes (Modic change): A systematic literature review of prevalence and association with non-specific low back pain. European Spine Journal, 17, 1407–1422. doi:10.1007/s00586-008-0770-2

Jeon, C.-H., Chung, N.-S., Lee, Y.-S., Son, K.-H., & Kim, J.-H. (2012). Assessment of Hip Abductor Power in Foot Drop Patients. Spine, 38(3), 1. doi:10.1097/BRS.0b013e318268c8bc

Johannessen, W., Cloyd, J. M., O'Connell, G. D., Vresilovic, E. J., & Elliott, D. M. (2006). Trans-endplate nucleotomy increases deformation and creep response in axial loading. Annals of Biomedical Engineering, 34(4), 687–696. doi:10.1007/s10439-005-9070-8

Johannessen, W., & Elliott, D. M. (2005). Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine, 30(24), E724–E729. doi:10.1097/01.brs.0000192236.92867.15

Johannessen, W., Vresilovic, E. J., Wright, A. C., & Elliott, D. M. (2004). Intervertebral disc mechanics are restored following cyclic loading and unloaded recovery. Annals of Biomedical Engineering, 32(1), 70–76. doi:10.1023/B:ABME.0000007792.19071.8c

Johnson, A. E., & Keller, T. S. (2008). Mechanical properties of open-cell foam synthetic thoracic vertebrae. Journal of Materials Science: Materials in Medicine, 19, 1317–1323. doi:10.1007/s10856-007-3158-7

Jones, A. R., Yelverton, C. J., & Bester, C. (2014). Ultrasound imaging of the trapeziometacarpal articular cavity to investigate the presence of intraarticular gas bubbles after chiropractic manipulation. Journal of Manipulative and Physiological Therapeutics, 37(7), 476–84. doi:10.1016/j.jmpt.2014.06.002

Jordan, J. M., Bernard, S. L., Callahan, L. F., Kincade, J. E., Konrad, T. R., & DeFriese, G. H. (2000). Self-reported arthritis-related disruptions in sleep and daily life and the use of medical, complementary, and self-care strategies for arthritis: the National Survey of Self-care and Aging. Archives of Family Medicine, 9, 143–149. doi:10.1001/archfami.9.2.149

Jurmain, R. (2000). Degenerative joint disease in African great apes: an evolutionary perspective. Journal of Human Evolution, 39(1956), 185–203. doi:10.1006/jhev.2000.0413

Kalichman, L., Kim, D. H., Li, L., Guermazi, A., Berkin, V., & Hunter, D. J. (2009). Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population. Spine, 34(2), 199–205. doi:10.1097/BRS.0b013e31818edcfd

Kandel, R. a, Hamilton, D., Séguin, C., Li, S.-Q., Arana, C., & Pilliar, R. (2007). An in vitro tissue model to study the effect of age on nucleus pulposus cells. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 16, 2166–2173. doi:10.1007/s00586-007-0467-y

Kaner, T., Sasani, M., Oktenoglu, T., Cosar, M., & Ozer,  a. F. (2010). Clinical outcomes after posterior dynamic transpedicular stabilization with limited lumbar discectomy: Carragee classification system for lumbar disc herniations. SAS Journal, 4(3), 92–97. doi:10.1016/j.esas.2010.06.001

Kang, J. D., & Bohlman, H. H. (2000). Cervical disc herniation in a patient with congenital insensitivity to pain: a case report. Spine, 25(13), 1726–1728.

Kanlayanaphotporn, R., Trott, P., Williams, M., & Fulton, I. (2003). Effects of chronic low back pain, age and gender on vertical spinal creep. Ergonomics, 46, 561–573. doi:10.1080/0014013031000066500

Kanlayanaphotporn, R., Williams, M., Fulton, I., & Trott, P. (2002). Reliability of the vertical spinal creep response measured in sitting (asymptomatic and low-back pain subjects). Ergonomics, 45, 240–247. doi:10.1080/00140130110115840

Kanno, H., Ozawa, H., Koizumi, Y., Morozumi, N., Aizawa, T., Kusakabe, T., … Itoi, E. (2012). Dynamic Change of Dural Sac Cross-Sectional Area in Axial Loaded Magnetic Resonance Imaging Correlates With the Severity of Clinical Symptoms in Patients With Lumbar Spinal Canal Stenosis. Spine, 37, 207–213. doi:10.1097/BRS.0b013e3182134e73

Kaptan, H., Kasimcan, O., Cakiroglu, K., Ilhan, M. N., & Kilic, C. (2007). Lumbar spinal stenosis in elderly patients. Annals of the New York Academy of Sciences, 1100, 173–178. doi:10.1196/annals.1395.015

Karabekir, H. S., Gocmen-Mas, N., Edizer, M., Ertekin, T., Yazici, C., & Atamturk, D. (2011). Lumbar vertebra morphometry and stereological assesment of intervertebral space volumetry: A methodological study. Annals of Anatomy, 193, 231–236. doi:10.1016/j.aanat.2011.01.011

Karadimas, E. J., Siddiqui, M., Smith, F. W., & Wardlaw, D. (2006). Positional MRI changes in supine versus sitting postures in patients with degenerative lumbar spine. Journal of Spinal Disorders & Techniques, 19(7), 495–500. doi:10.1097/01.bsd.0000211213.98070.c2

Karkashan, E. M., Joharji, H. S., & Al-Harbi, N. N. (2002). Congenital insensitivity to pain in four related Saudi families. Pediatric Dermatology, 19(4), 333–335. doi:10.1046/j.1525-1470.2002.00095.x

Kato, F., Yukawa, Y., Suda, K., Yamagata, M., & Ueta, T. (2012). Normal morphology, age-related changes and abnormal findings of the cervical spine. Part II: Magnetic resonance imaging of over 1,200 asymptomatic subjects. European Spine Journal, 21, 1499–1507. doi:10.1007/s00586-012-2176-4

Kauppila, L. I. (2010). Ingrowth of Blood Vessels in Disc Degeneration.

Kawchuk, G. N., Fryer, J., Jaremko, J. L., Zeng, H., Rowe, L., & Thompson, R. (2015). Real-Time Visualization of Joint Cavitation. PLOS ONE, 10(4), e0119470. doi:10.1371/journal.pone.0119470

Keeney, B. J., Fulton-Kehoe, D., Turner, J. a, Wickizer, T. M., Chan, K. C. G., & Franklin, G. M. (2013). Early predictors of lumbar spine surgery after occupational back injury: results from a prospective study of workers in Washington State. Spine, 38(11), 953–64. doi:10.1097/BRS.0b013e3182814ed5

Keller, A. (1972). The Influence of the Cavitation Nucleus Spectrum on Cavitation Inception, Investigated With a Scattered Light Counting Method. Journal of Basic Engineering, 94(4), 917. doi:10.1115/1.3425590

Keller, A., Boyle, E., Skog, T. a., David Cassidy, J., & Bautz-Holter, E. (2012). Are Modic changes prognostic for recovery in a cohort of patients with non-specific low back pain? European Spine Journal, 21, 418–424. doi:10.1007/s00586-011-1964-6

Kepler, C. K., Ponnappan, R. K., Tannoury, C. a, Risbud, M. V, & Anderson, D. G. (2013). The molecular basis of intervertebral disc degeneration. The Spine Journal : Official Journal of the North American Spine Society, 13, 318–30. doi:10.1016/j.spinee.2012.12.003

Key, S., Adams, M. A., & Stefanakis, M. (2012). Healing of painful intervertebral discs: implications for physiotherapy Part 2-pressure change therapy: a proposed clinical model to stimulate disc healing. Physical Therapy Reviews. doi:10.1179/1743288X12Y.0000000038

Khan, I. M., Evans, S. L., Young, R. D., Blain, E. J., Quantock, A. J., Avery, N., & Archer, C. W. (2011). Fibroblast growth factor 2 and transforming growth factor β1 induce precocious maturation of articular cartilage. Arthritis and Rheumatism, 63(11), 3417–3427. doi:10.1002/art.30543

Kier, W. M., & Smith, A. M. (1990). The Morphology and Mechanics of Octopus Suckers. Biol. Bull., 178(2), 126–136. Retrieved from

Kim, K. W., Chung, H. N., Ha, K. Y., Lee, J. S., & Kim, Y. Y. (2009). Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs. Spine Journal, 9(8), 658–666. doi:10.1016/j.spinee.2009.04.018

Kim, K. W., Ha, K. Y., Lee, J. S., Nam, S. W., Woo, Y. K., Lim, T. H., & An, H. S. (2009a). Notochordal cells stimulate migration of cartilage end plate chondrocytes of the intervertebral disc in in vitro cell migration assays. Spine Journal, 9, 323–329. doi:10.1016/j.spinee.2008.05.003

Kim, K. W., Ha, K. Y., Lee, J. S., Nam, S. W., Woo, Y. K., Lim, T. H., & An, H. S. (2009b). Notochordal cells stimulate migration of cartilage end plate chondrocytes of the intervertebral disc in in vitro cell migration assays. Spine Journal, 9(4), 323–329. doi:10.1016/j.spinee.2008.05.003

Kirkaldy-Willis, W. H., & Cassidy, J. D. (1985). Spinal manipulation in the treatment of low-back pain. Canadian Family Physician Medecin de Famille Canadien, 31(March), 535–540. doi:10.1016/S0140-6736(64)91013-X

Kogan, F., Hariharan, H., & Reddy, R. (2013). Chemical Exchange Saturation Transfer (CEST) Imaging: Description of Technique and Potential Clinical Applications. Current Radiology Reports, 1, 102–114. doi:10.1007/s40134-013-0010-3

Kohyama, J. (2001). REM sleep atonia: From basic background to clinical application. Journal of Medical and Dental Sciences, 48, 29–39.

Kokubo, Y., Uchida, K., Kobayashi, S., Yayama, T., Sato, R., Nakajima, H., … Baba, H. (2008). Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological findings in 500 en bloc surgical samples. Laboratory investigation. Journal of Neurosurgery. Spine, 9(September), 285–295. doi:10.3171/SPI/2008/9/9/285

Korecki, C. L., Costi, J. J., & Iatridis, J. C. (2008). Needle puncture injury affects intervertebral disc mechanics and biology in an organ culture model. Spine, 33(3), 235–241. doi:10.1097/BRS.0b013e3181624504

Korecki, C. L., Kuo, C. K., Tuan, R. S., & Iatridis, J. C. (2009). Intervertebral disc cell response to dynamic compression is age and frequency dependent. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 27, 800–806. doi:10.1002/jor.20814

Kos, J., Hert, J., & Sevcík, P. (2002). [Meniscoids of the intervertebral joints]. Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca, 69(3), 149–57. Retrieved from

Kourtis, D., Magnusson, M. L., Smith, F., Hadjipavlou, A., & Pope, M. H. (2004). Spine height and disc height changes as the effect of hyperextension using stadiometry and MRI. The Iowa Orthopaedic Journal, 24, 65–71.

Kraemer, J., Kolditz, D., & Gowin, R. (n.d.). Water and electrolyte content of human intervertebral discs under variable load. Spine.

Kramer, P. A., Newell-Morris, L. L., & Simkin, P. a. (2002). Spinal degenerative disk disease (DDD) in female macaque monkeys: Epidemiology and comparison with women. Journal of Orthopaedic Research, 20, 399–408. doi:10.1016/S0736-0266(01)00122-X

Krishan, K., & Vij, K. (2007). Diurnal Variation of Stature in Three Adults and One Child, 9(2), 113–117.

Kroeber, M., Unglaub, F., Guehring, T., Nerlich, A., Hadi, T., Lotz, J., & Carstens, C. (2005). Effects of controlled dynamic disc distraction on degenerated intervertebral discs: an in vivo study on the rabbit lumbar spine model. Spine, 30(2), 181–187. doi:10.1097/01.brs.0000150487.17562.b1

Kroeber, M. W., Unglaub, F., Wang, H., Schmid, C., Thomsen, M., Nerlich, A., & Richter, W. (2002). New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration. Spine, 27(23), 2684–2690. doi:10.1097/00007632-200212010-00007

Kuisma, M., Karppinen, J., Haapea, M., Niinimäki, J., Ojala, R., Heliövaara, M., … Tervonen, O. (2008). Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers. BMC Musculoskeletal Disorders, 9, 51. doi:10.1186/1471-2474-9-51

Kuisma, M., Karppinen, J., Niinimäki, J., Ojala, R., Haapea, M., Heliövaara, M., … Tervonen, O. (2007). Modic changes in endplates of lumbar vertebral bodies: prevalence and association with low back and sciatic pain among middle-aged male workers. Spine, 32(10), 1116–1122. doi:10.1097/01.brs.0000261561.12944.ff

Kumar, A., Beastall, J., Hughes, J., Karadimas, E. J., Nicol, M., Smith, F., & Wardlaw, D. (2008). Disc changes in the bridged and adjacent segments after Dynesys dynamic stabilization system after two years. Spine, 33(26), 2909–2914. doi:10.1097/BRS.0b013e31818bdca7

Kumaresan, S., Yoganandan, N., & Pintar, F. a. (1998). Finite element modeling approaches of human cervical spine facet joint capsule. Journal of Biomechanics, 31, 371–376.

Kunseler, E. (2007). Towards a new paradigm of science. Thought A Review Of Culture And Idea, 67(8), 1–5. doi:10.1002/art.39177

Kuo, Y.-W., & Wang, J.-L. (2010). Rheology of Intervertebral Disc. Spine, 35(16), E743–E752. doi:10.1097/BRS.0b013e3181d7a839

Kurutz, M. (2005). x Finite Element Modeling of the Human Lumbar Spine, (1987).

Lafon, Y., Lafage, V., Steib, J.-P., Dubousset, J., & Skalli, W. (2010). In vivo distribution of spinal intervertebral stiffness based on clinical flexibility tests. Spine, 35(2), 186–193. doi:10.1097/BRS.0b013e3181b664b1

Lai, A., & Chow, D. H. K. (2010). Effects of traction on structural properties of degenerated disc using an in vivo rat-tail model. Spine, 35(14), 1339–1345. doi:10.1097/BRS.0b013e3181c617f6

Lai, A., Chow, D. H. K., Siu, W. S., Holmes, A. D., & Tang, F. H. (2007). Reliability of radiographic intervertebral disc height measurement for in vivo rat-tail model. Medical Engineering and Physics, 29, 814–819. doi:10.1016/j.medengphy.2006.08.013

Lai, C. S., & Siegel, J. (1999). Muscle atonia in REM sleep. Rapid Eye Movement Sleep, (1959), 69–90.

Langrana, N. a., Kale, S. P., Edwards, W. T., Lee, C. K., & Kopacz, K. J. (2006). Measurement and analyses of the effects of adjacent end plate curvatures on vertebral stresses. Spine Journal, 6, 267–278. doi:10.1016/j.spinee.2005.09.008

Laroche, M. (2002). Intraosseous circulation from physiology to disease. Joint Bone Spine, 69(figure 1), 262–269. doi:10.1016/S1297-319X(02)00391-3

Latridis, J. C., Godburn, K., Wuertz, K., Alini, M., & Roughley, P. J. (2011). Region-dependent aggrecan degradation patterns in the rat intervertebral disc are affected by mechanical loading in vivo. Spine, 36(Xx), 203–209. doi:10.1097/BRS.0b013e3181cec247

Lauterborn, W., & Ohl, C. (1997). Cavitation bubble dynamics. Ultrasonics Sonochemistry, 4, 65–75. Retrieved from

Lee, D. C., Adams, C. S., Albert, T. J., Shapiro, I. M., Evans, S. M., & Koch, C. J. (2007). In situ oxygen utilization in the rat intervertebral disc. Journal of Anatomy, 210, 294–303. doi:10.1111/j.1469-7580.2007.00692.x

Lee, M. J., Dettori, J. R., Standaert, C. J., Brodt, E. D., & Chapman, J. R. (2012). The Natural History of Degeneration of the Lumbar and Cervical Spines. Spine, 37(22), S18–S30. doi:10.1097/BRS.0b013e31826cac62

Lee, M. J., & Riew, K. D. (2009). The prevalence cervical facet arthrosis: an osseous study in a cadveric population. Spine Journal, 9(9), 711–714. doi:10.1016/j.spinee.2009.04.016

Lee, S., Lee, J. W., Yeom, J. S., Kim, K. J., Kim, H. J., Chung Soo Kyo, & Kang, H. S. (2010). A practical MRI grading system for lumbar foraminal stenosis. American Journal of Roentgenology, 194(April), 1095–1098. doi:10.2214/AJR.09.2772

Lee, S.-H., Im, Y.-J., Kim, K.-T., Kim, Y.-H., Park, W.-M., & Kim, K. (2011). Comparison of cervical spine biomechanics after fixed- and mobile-core artificial disc replacement: a finite element analysis. Spine, 36, 700–708. doi:10.1097/BRS.0b013e3181f5cb87

Leivseth, G., & Drerup, B. (1997). Spinal shrinkage during work in a sitting posture compared to work in a standing posture. Clinical Biomechanics, 12(7), 409–418. doi:10.1016/S0268-0033(97)00046-6

Lengsfeld, M., Frank,  a., Van Deursen, D. L., & Griss, P. (2001). Lumbar spine curvature during office chair sitting. Medical Engineering and Physics, 22(2000), 665–669. doi:10.1016/S1350-4533(00)00086-2

Lettin,  a W. (1967). Diagnosis and treatment of lumbar instability. The Journal of Bone and Joint Surgery. British Volume.

Levick, J. R. (1995). Microvascular architecture and exchange in synovial joints. Microcirculation (New York, N.Y. : 1994), 2(3), 217–33. Retrieved from

Lewis, R. a., Williams, N. H., Sutton, A. J., Burton, K., Din, N. U., Matar, H. E., … Wilkinson, C. (2014). Comparative clinical effectiveness of management strategies for sciatica: systematic review and network meta-analyses. Spine Journal. doi:10.1016/j.spinee.2013.08.049

Li, G., & Haslegrave, C. M. (1999). Seated work postures for manual, visual and combined tasks. Ergonomics, 42, 1060–1086. doi:10.1080/001401399185144

Li, X. F., Gregory, J., & Ahmed,  a. (1994). Immunolocalisation of vascular endothelial growth factor in human endometrium. Growth Factors (Chur, Switzerland), 11, 277–282.

Liang, Q.-Q., Cui, X.-J., Xi, Z.-J., Bian, Q., Hou, W., Zhao, Y.-J., … Wang, Y.-J. (2011). Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine. Spine, 36(Xx), E14–E19. doi:10.1097/BRS.0b013e3181d2dec2

Lidtke, R. H., & George, J. Anatomy, biomechanics, and surgical approach to synovial folds within the joints of the foot. Journal of the American Podiatric Medical Association, 94(6), 519–27. Retrieved from

Liebenson, C. (2010). Postural exercises on the foam roll. Journal of Bodywork and Movement Therapies, 14, 203–205. doi:10.1016/j.jbmt.2010.02.003

Lievers, W. B., Poljsak,  a. S., Waldman, S. D., & Pilkey,  a. K. (2010). Effects of dehydration-induced structural and material changes on the apparent modulus of cancellous bone. Medical Engineering and Physics, 32(8), 921–925. doi:10.1016/j.medengphy.2010.06.001

Linley, S. E., Peterson, J., Mastropolo, R., Timothy, T., Lawrence, J. P., Glennon, J. C., … Ledet, E. H. (2015). AC. The Spine Journal. doi:10.1016/j.spinee.2014.12.003

Linscott, M. S., & Heyborne, R. (2007). Thoracic Intervertebral Disk Herniation: A Commonly Missed Diagnosis. Journal of Emergency Medicine, 32(3), 235–238. doi:10.1016/j.jemermed.2006.06.010

Lis, A. M., Black, K. M., Korn, H., & Nordin, M. (2007). Association between sitting and occupational LBP. European Spine Journal, 16, 283–298. doi:10.1007/s00586-006-0143-7

Little, J. S., & Khalsa, P. S. (2005). Human lumbar spine creep during cyclic and static flexion: Creep rate, biomechanics, and facet joint capsule strain. Annals of Biomedical Engineering, 33(3), 391–401. doi:10.1007/s10439-005-1742-x

Litwic, A., Edwards, M. H., Dennison, E. M., & Cooper, C. (2013). Epidemiology and burden of osteoarthritis. British Medical Bulletin, 105, 185–99. doi:10.1093/bmb/lds038

Liu, J., Ebraheim, N. a, Haman, S. P., Shafiq, Q., Karkare, N., Biyani, A., … Woldenberg, L. (2006). Effect of the increase in the height of lumbar disc space on facet joint articulation area in sagittal plane. Spine, 31(7), E198–E202. doi:10.1097/01.brs.0000206387.67098.a0

Long, A., Donelson, R., & Fung, T. (2004). Does it matter which exercise? A randomized control trial of exercise for low back pain. Spine, 29(23), 2593–2602. doi:00007632-200412010-00002 [pii]

Lorefält, B., Toss, G., & Granérus,  a-K. (2007). Bone mass in elderly patients with Parkinson’s disease. Acta Neurologica Scandinavica, 116, 248–254. doi:10.1111/j.1600-0404.2007.00875.x

Lotz, J. C. (2004). Animal models of intervertebral disc degeneration: lessons learned. Spine, 29(23), 2742–2750. doi:00007632-200412010-00018 [pii]

Lotz, J. C., Hadi, T., Bratton, C., Reiser, K. M., & Hsieh, A. H. (2008). Anulus fibrosus tension inhibits degenerative structural changes in lamellar collagen. European Spine Journal, 17, 1149–1159. doi:10.1007/s00586-008-0721-y

Ludescher, B., Effelsberg, J., Martirosian, P., Steidle, G., Markert, B., Claussen, C., & Schick, F. (2008). T2- and diffusion-maps reveal diurnal changes of intervertebral disc composition: An in vivo MRI study at 1.5 tesla. Journal of Magnetic Resonance Imaging, 28, 252–257. doi:10.1002/jmri.21390

Lundin, O., Ekström, L., Hellström, M., Holm, S., & Swärd, L. (1998). Injuries in the adolescent porcine spine exposed to mechanical compression. Spine, 23(23), 2574–2579. doi:10.1097/00007632-199812010-00012

Lung, Y., & Israelachvili, J. (2014). New Mechanism of Cavitation Damage, 252(5009), 1157–1160.

Lyons, T. J., Stoddart, R. W., McClure, S. F., & McClure, J. (2005). The tidemark of the chondro-osseous junction of the normal human knee joint. Journal of Molecular Histology, 36, 207–215. doi:10.1007/s10735-005-3283-x

Macki, M., Hernandez-Hermann, M., Bydon, M., Gokaslan, A., McGovern, K., & Bydon, A. (2014). Spontaneous regression of sequestrated lumbar disc herniations: Literature review. Clinical Neurology and Neurosurgery, 120, 136–141. doi:10.1016/j.clineuro.2014.02.013

Mackie, E. J., Ahmed, Y. a., Tatarczuch, L., Chen, K. S., & Mirams, M. (2008). Endochondral ossification: How cartilage is converted into bone in the developing skeleton. International Journal of Biochemistry and Cell Biology, 40, 46–62. doi:10.1016/j.biocel.2007.06.009

MacLean, J. J., Lee, C. R., Alini, M., & Iatridis, J. C. (2004). Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression. Journal of Orthopaedic Research, 22, 1193–1200. doi:10.1016/j.orthres.2004.04.004

MacLean, J. J., Roughley, P. J., Monsey, R. D., Alini, M., & Iatridis, J. C. (2008). In vivo intervertebral disc remodeling: Kinetics of mRNA expression in response to a single loading event. Journal of Orthopaedic Research, 26(May), 579–588. doi:10.1002/jor.20560

Madsen, R., Jensen, T. S., Pope, M., Sørensen, J. S., & Bendix, T. (2008). The Effect of Body Position and Axial Load on Spinal Canal Morphology. Spine, 33(1), 61–67. doi:10.1097/BRS.0b013e31815e395f


Magnier, C., Wendling-Mansuy, S., Boiron, O., Deplano, V., & Chabrand, P. (2008). Nutrient Transport Into a Loaded Intervertebral Disc: a Parametric Study. Journal of Biomechanics, 41(July), S360. doi:10.1016/S0021-9290(08)70359-2

Magnusson, M. L., Aleksiev, A. R., Spratt, K. F., Lakes, R. S., & Pope, M. H. (1996). Hyperextension and spine height changes. Spine, 21(22), 2670–2675. doi:10.1097/00007632-199611150-00017

Makhsous, M., Lin, F., Bankard, J., Hendrix, R. W., Hepler, M., & Press, J. (2009). Biomechanical effects of sitting with adjustable ischial and lumbar support on occupational low back pain: evaluation of sitting load and back muscle activity. BMC Musculoskeletal Disorders, 10, 17. doi:10.1186/1471-2474-10-17

Malandrino,  a., Lacroix, D., Hellmich, C., Ito, K., Ferguson, S. J., & Noailly, J. (2014). The role of endplate poromechanical properties on the nutrient availability in the intervertebral disc. Osteoarthritis and Cartilage, 22, 1053–1060. doi:10.1016/j.joca.2014.05.005

Malik, K. M., Cohen, S. P., Walega, D. R., & Benzon, H. T. (2013). Diagnostic criteria and treatment of discogenic pain: a systematic review of recent clinical literature. The Spine Journal : Official Journal of the North American Spine Society, 13, 1675–89. doi:10.1016/j.spinee.2013.06.063

Malko, J. a, Hutton, W. C., & Fajman, W. a. (2002). An in vivo MRI study of the changes in volume (and fluid content) of the lumbar intervertebral disc after overnight bed rest and during an 8-hour walking protocol. Journal of Spinal Disorders & Techniques, 15(2), 157–163. doi:10.1097/00024720-200204000-00012

Man, G. S., & Mologhianu, G. (2014). Osteoarthritis pathogenesis – a complex process that involves the entire joint. Journal of Medicine and Life, 7(1), 37–41. Retrieved from

Mapp, P. I., & Walsh, D. a. (2012). Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.80

Marijnissen, A. C. a, Van Roermund, P. M., Van Melkebeek, J., Schenk, W., Verbout, A. J., Bijlsma, J. W. J., & Lafeber, F. P. J. G. (2002). Clinical benefit of joint distraction in the treatment of severe osteoarthritis of the ankle: Proof of concept in an open prospective study and in a randomized controlled study. Arthritis and Rheumatism, 46(11), 2893–2902. doi:10.1002/art.10612

Marras, C., & Lang, A. (2008). Invited article: Changing concepts in Parkinson disease: Moving beyond the Decade of the Brain. Neurology, 70, 1996–2003. doi:10.1212/01.wnl.0000312515.52545.51

Marshall, L. W., & McGill, S. M. (2010). The role of axial torque in disc herniation. Clinical Biomechanics, 25(1), 6–9. doi:10.1016/j.clinbiomech.2009.09.003

Martin, M. D., Boxell, C. M., & Malone, D. G. (2002). Pathophysiology of lumbar disc degeneration: a review of the literature. Neurosurgical Focus, 13(2), E1. doi:10.3171/foc.2002.13.2.2

Marwah, R. S., Doux, J. D., Lee, P. Y., & Yun, A. J. (2007). Is atherosclerosis a neurogenic phenomenon? Medical Hypotheses, 69, 884–887. doi:10.1016/j.mehy.2007.01.066

Masuoka, K., Michalek, A. J., MacLean, J. J., Stokes, I. a F., & Iatridis, J. C. (2007). Different effects of static versus cyclic compressive loading on rat intervertebral disc height and water loss in vitro. Spine, 32(18), 1974–1979. doi:10.1097/BRS.0b013e318133d591

Matsumoto, M., Okada, E., Ichihara, D., Chiba, K., Toyama, Y., Fujiwara, H., … Takahata, T. (2010). Prospective ten-year follow-up study comparing patients with whiplash-associated disorders and asymptomatic subjects using magnetic resonance imaging. Spine, 35(18), 1684–1690. doi:10.1097/BRS.0b013e3181c9a8c7

Matsumoto, M., Watanabe, K., Tsuji, T., Ishii, K., Takaishi, H., Nakamura, M., … Nishiwaki, Y. (2009). Nocturnal leg cramps: a common complaint in patients with lumbar spinal canal stenosis. Spine, 34(5), E189–E194. doi:10.1097/BRS.0b013e31818f953c

Matsumura, Y., Kasai, Y., Obata, H., Matsushima, S., Inaba, T., & Uchida, A. (2009). Changes in water content of intervertebral discs and paravertebral muscles before and after bed rest. Journal of Orthopaedic Science, 14, 45–50. doi:10.1007/s00776-008-1288-5

Matula, T. J. (2000). Single-bubble sonoluminescence in microgravity. Ultrasonics, 38, 559–565. doi:10.1016/S0041-624X(99)00217-6

May, H., Pathologic, C., Degeneration, D., & Data, A. M. (2006). Pathologic Disc Degeneration : Review of Animal Model Data, 76–83.

McCarthy, D. M., Buckley, B. a., Engel, K. G., Forth, V. E., Adams, J. G., & Cameron, K. a. (2013). Understanding patient-provider conversations: What are we talking about? Academic Emergency Medicine, 20, 441–448. doi:10.1111/acem.12138

McClellan, J., Woodward, H. R., Longley, M., Fuller, J., Burd, T., Phillips, E., … Mains, C. (2007). 19. Transforaminal Lumbar Interbody Fusion with Bone Morphogenetic Protein (rhBMP-2) – A Computed Tomography Assessment Of Fusion. The Spine Journal, 7, 9S–10S. doi:10.1016/j.spinee.2007.07.025

McDonald, C. P., Bachison, C. C., Chang, V., Bartol, S. W., & Bey, M. J. (2010). Three-dimensional dynamic in vivo motion of the cervical spine: assessment of measurement accuracy and preliminary findings. Spine Journal, 10(6), 497–504. doi:10.1016/j.spinee.2010.02.024

McGill, S. (2010). Core Training: Evidence Translating to Better Performance and Injury Prevention. Strength and Conditioning Journal, 32, 33–46. doi:10.1519/SSC.0b013e3181df4521

McGill, S. M., & Axler, C. T. (1996). Changes in spine height throughout 32 hours of bedrest. Archives of Physical Medicine and Rehabilitation. doi:10.1016/S0003-9993(96)90071-4

McGill, S. M., Kavcic, N. S., & Harvey, E. (2006). Sitting on a chair or an exercise ball: Various perspectives to guide decision making. Clinical Biomechanics, 21, 353–360. doi:10.1016/j.clinbiomech.2005.11.006

Mclean, L., Mclean, L., Tingley, M., Tingley, M., Scott, N., Scott, N., … Rickards, J. (2001). Computer terminal work and the bene”t of microbreaks. Applied Ergonomics, 32, 225–237.

McMillan, D. W., Garbutt, G., & Adams, M. a. (1996). Effect of sustained loading on the water content of intervertebral discs: implications for disc metabolism. Annals of the Rheumatic Diseases, 55, 880–887. doi:10.1136/ard.55.12.880

Meakin, J. R., Smith, F. W., Gilbert, F. J., & Aspden, R. M. (2008). The effect of axial load on the sagittal plane curvature of the upright human spine in vivo. Journal of Biomechanics, 41, 2850–2854. doi:10.1016/j.jbiomech.2008.06.035

Méal, G. M., & Scott, R. A. (1986). Analysis of the joint crack by simultaneous recording of sound and tension. Journal of Manipulative and Physiological Therapeutics, 9(3), 189–195.

Measurement of time-dependent height-loss during sitting.pdf. (n.d.).

Measuring disc heights comparing methods by MRI. (n.d.).

Medicines, T., & Agency, R. (2009). Drug Safety, (992).

Melrose, J., Smith, S. M., Little, C. B., Moore, R. J., Vernon-Roberts, B., & Fraser, R. D. (2008). Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. European Spine Journal, 17, 1131–1148. doi:10.1007/s00586-008-0712-z

Mennell, J. B. (1939). The Science and Art of Joint Manipulation: The extremities, Volume 1. Churchill. Retrieved from

Mercer, S., & Bogduk, N. (1999). The ligaments and annulus fibrosus of human adult cervical intervertebral discs. Spine, 24(7), 619–626; discussion 627–628.

Mierau, D ; Cassidy, J ; Bowen, P ; Dupuis, P ; Noftall, F. (1988). Manipulation and mobilization of the third metacarpalphalangeal joint. Manual Medicine.

Miyazaki, M., Hong, S. W., Yoon, S. H., Zou, J., Tow, B., Alanay, A., … Wang, J. C. (2008). Kinematic analysis of the relationship between the grade of disc degeneration and motion unit of the cervical spine. Spine, 33(2), 187–193. doi:10.1097/BRS.0b013e3181604501

Mladenovic, A., Perovic, M., Tanic, N., Petanceska, S., Ruzdijic, S., & Kanazir, S. (2007a). Dietary restriction modulates alpha-synuclein expression in the aging rat cortex and hippocampus. Synapse (New York, N.Y.), 61(April 2007), 790–794. doi:10.1002/syn

Mladenovic, A., Perovic, M., Tanic, N., Petanceska, S., Ruzdijic, S., & Kanazir, S. (2007b). Dietary restriction modulates alpha-synuclein expression in the aging rat cortex and hippocampus. Synapse (New York, N.Y.), 61, 790–794. doi:10.1002/syn

Modarreszadeh, S., Abouali, O., Ghaffarieh, A., & Ahmadi, G. (2014). Physiology of aqueous humor dynamic in the anterior chamber due to rapid eye movement. Physiology and Behavior, 135, 112–118. doi:10.1016/j.physbeh.2014.05.017

Modic, M. T., & Ross, J. S. (2007). Lumbar degenerative disk disease. Radiology, 245(1), 43–61. doi:10.1148/radiol.2451051706

Mokhbi Soukane, D., Shirazi-Adl,  a., & Urban, J. P. G. (2007). Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc. Journal of Biomechanics, 40, 2645–2654. doi:10.1016/j.jbiomech.2007.01.003

Moldofsky, H. (2008). The significance of the sleeping-waking brain for the understanding of widespread musculoskeletal pain and fatigue in fibromyalgia syndrome and allied syndromes. Joint Bone Spine, 75, 397–402. doi:10.1016/j.jbspin.2008.01.021

Mollan, B. (1989). rc 5)., 45–47.

Moore, M. K., Fulop, S., Tabib-Azar, M., & Hart, D. J. (2009). Piezoresistive pressure sensors in the measurement of intervertebral disc hydrostatic pressure. Spine Journal, 9, 1030–1034. doi:10.1016/j.spinee.2009.08.462

Moore, R. J. (2006a). The vertebral endplate: Disc degeneration, disc regeneration. European Spine Journal, 15, 1–9. doi:10.1007/s00586-006-0170-4

Moore, R. J. (2006b). The vertebral endplate: Disc degeneration, disc regeneration. European Spine Journal, 15, 333–337. doi:10.1007/s00586-006-0170-4

Morales, F. R., Sampogna, S., Rampon, C., Luppi, P. H., & Chase, M. H. (2006). Brainstem glycinergic neurons and their activation during active (rapid eye movement) sleep in the cat. Neuroscience, 142, 37–47. doi:10.1016/j.neuroscience.2006.05.066

Morishita, Y., Hida, S., Naito, M., Arimizu, J., Matsushima, U., & Nakamura, A. (2006). Measurement of the local pressure of the intervertebral foramen and the electrophysiologic values of the spinal nerve roots in the vertebral foramen. Spine, 31(26), 3076–3080. doi:10.1097/01.brs.0000249559.96787.d4

Morphology and functional roles of synoviocytes in the joint.pdf. (n.d.).

Mothersill, C., Seymour, C. B., & O'Brien,  a. (1991a). Induction of c-myc oncoprotein and of cellular proliferation by radiation in normal human urothelial cultures. Anticancer Research, 11(October), 1609–1612. doi:10.1002/jor

Mothersill, C., Seymour, C. B., & O'Brien,  a. (1991b). Induction of c-myc oncoprotein and of cellular proliferation by radiation in normal human urothelial cultures. Anticancer Research, 11(June), 1609–1612. doi:10.1002/jor

Moyer, R. F., Ratneswaran, A., Beier, F., & Birmingham, T. B. (2014). Osteoarthritis Year in Review 2014 : mechanics e basic and clinical studies in osteoarthritis. Osteoarthritis and Cartilage, 22(12), 1989–2002. doi:10.1016/j.joca.2014.06.034

MR Imaging of the Metacarpophalangeal Joints of the Fingers part 1.pdf. (n.d.).

MR Imaging of the Metacarpophalangeal Joints of the Fingers part 2.pdf. (n.d.).

Muftuler, L. T., Jarman, J. P., Yu, H. J., Gardner, V. O., Maiman, D. J., & Arpinar, V. E. (2014). Association between intervertebral disc degeneration and endplate perfusion studied by DCE-MRI. doi:10.1007/s00586-014-3690-3

Muir, P., McCarthy, J., Radtke, C. L., Markel, M. D., Santschi, E. M., Scollay, M. C., & Kalscheur, V. L. (2006). Role of endochondral ossification of articular cartilage and functional adaptation of the subchondral plate in the development of fatigue microcracking of joints. Bone, 38(2006), 342–349. doi:10.1016/j.bone.2005.08.020

Müller, A., Vogt, P., Kuhn, J., & Müller, M. (2015). Cracking knuckles — A smartphone inquiry on bioacoustics. The Physics Teacher, 53(5), 307–308. doi:10.1119/1.4917442

Murphy, M. a. (1988, April). Analysis of the joint crack by simultaneous recording of sound and tensions. Journal of Manipulative and Physiological Therapeutics. Retrieved from

Mwale, F., Ciobanu, I., Giannitsios, D., Roughley, P., Steffen, T., & Antoniou, J. (2011). Effect of oxygen levels on proteoglycan synthesis by intervertebral disc cells. Spine, 36(Xx), E131–E138. doi:10.1097/BRS.0b013e3181d52b9e

Nakamura, T., Iribe, T., Asou, Y., Miyairi, H., Ikegami, K., & Takakuda, K. (2009). Effects of compressive loading on biomechanical properties of disc and peripheral tissue in a rat tail model. European Spine Journal, 18, 1595–1603. doi:10.1007/s00586-009-1078-6

Nazari, J., Pope, M. H., & Graveling, R. a. (2012). Reality about migration of the nucleus pulposus within the intervertebral disc with changing postures. Clinical Biomechanics, 27, 213–217. doi:10.1016/j.clinbiomech.2011.09.011

Nègre-Pagès, L., Regragui, W., Bouhassira, D., Grandjean, H., & Rascol, O. (2008). Chronic pain in Parkinson’s disease: The cross-sectional French DoPaMiP survey. Movement Disorders, 23(10), 1361–1369. doi:10.1002/mds.22142

Nekkanty, S., Yerramshetty, J., Kim, D. G., Zauel, R., Johnson, E., Cody, D. D., & Yeni, Y. N. (2010). Stiffness of the endplate boundary layer and endplate surface topography are associated with brittleness of human whole vertebral bodies. Bone, 47(4), 783–789. doi:10.1016/j.bone.2010.07.001

Nepple, J. J., Philippon, M. J., Campbell, K. J., Dornan, G. J., Jansson, K. S., LaPrade, R. F., & Wijdicks, C. A. (2014). The hip fluid seal–Part II: The effect of an acetabular labral tear, repair, resection, and reconstruction on hip stability to distraction. Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA, 22(4), 730–6. doi:10.1007/s00167-014-2875-y

Nicholson, P. H., Cheng, X. G., Lowet, G., Boonen, S., Davie, M. W., Dequeker, J., & Van der Perre, G. (1997). Structural and material mechanical properties of human vertebral cancellous bone. Medical Engineering & Physics, 19(8), 729–737.

Niek, C., Ernst, H., Lim, L., Poortman, A., & Marti, R. K. (n.d.). Ballet Dancers Degenerative.

Niinimäki, J., Korkiakoski, A., Parviainen, O., Haapea, M., Kuisma, M., Ojala, R. O., … Nieminen, M. T. (2009). Association of lumbar artery narrowing, degenerative changes in disc and endplate and apparent diffusion in disc on postcontrast enhancement of lumbar intervertebral disc. Magnetic Resonance Materials in Physics, Biology and Medicine, 22, 101–109. doi:10.1007/s10334-008-0151-1

Nilsson, N., Christensen, H. W., & Hartvigsen, J. (1996). Lasting changes in passive range motion after spinal manipulation: a randomized, blind, controlled trial. Journal of Manipulative and Physiological Therapeutics, 19(3), 165–8. Retrieved from

Noailly, J., Wilke, H. J., Planell, J. a., & Lacroix, D. (2007). How does the geometry affect the internal biomechanics of a lumbar spine bi-segment finite element model? Consequences on the validation process. Journal of Biomechanics, 40, 2414–2425. doi:10.1016/j.jbiomech.2006.11.021

Nowlan, N. C., & Sharpe, J. (2014). Joint shape morphogenesis precedes cavitation of the developing hip joint. Journal of Anatomy, 224, 482–489. doi:10.1111/joa.12143

Nucleus pulposus degeneration and its role in intervertebral disc mechanical function. (n.d.).

O’Connell, G. D., Johannessen, W., Vresilovic, E. J., & Elliott, D. M. (2007). Human internal disc strains in axial compression measured noninvasively using magnetic resonance imaging. Spine, 32(25), 2860–2868. doi:10.1097/BRS.0b013e31815b75fb

O’Connell, G. D., Vresilovic, E. J., & Elliott, D. M. (2007). Comparison of animals used in disc research to human lumbar disc geometry. Spine, 32(3), 328–333. doi:10.1097/01.brs.0000253961.40910.c1

O’Connell, G. D., Vresilovic, E. J., & Elliott, D. M. (2011). Human intervertebral disc internal strain in compression: The effect of disc region, loading position, and degeneration. Journal of Orthopaedic Research, 29, 547–555. doi:10.1002/jor.21232

O’Donoghue, G. M., Fox, N., Heneghan, C., & Hurley, D. a. (2009). Objective and subjective assessment of sleep in chronic low back pain patients compared with healthy age and gender matched controls: a pilot study. BMC Musculoskeletal Disorders, 10, 122. doi:10.1186/1471-2474-10-122

O’Neill, C. W. (2013). Commentary: Diagnostic tests for chronic low back pain–a dismal science. The Spine Journal : Official Journal of the North American Spine Society, 13(2), 113–5. doi:10.1016/j.spinee.2012.11.044

O’Sullivan, P., Dankaerts, W., Burnett, A., Chen, D., Booth, R., Carlsen, C., & Schultz, A. (2006). Evaluation of the flexion relaxation phenomenon of the trunk muscles in sitting. Spine, 31(17), 2009–2016. doi:10.1097/01.brs.0000228845.27561.e0

Ochia, R. S., & Ching, R. P. (2006). Rate dependence of hydraulic resistance in human lumbar vertebral bodies. Spine, 31(22), 2569–2574. doi:10.1097/01.brs.0000240648.51087.c9

Odile Gabay, PhD, Christelle Sanchez, PhD, Mona Dvir-Ginzberg, PhD, Viktoria Gagarina, MD, PhD, Kristien J Zaal, PhD, Yingjie Song, MS5, Xiao Hong He, MS, Michael W McBurney, P. (2012). Sirt1 enzymatic activity is required for cartilage homeostasis in vivo. Arthritis & Rheumatism, 1–30. doi:10.1002/art.

Ohtori, S., Inoue, G., Miyagi, M., & Takahashi, K. (2014). Pathomechanisms of discogenic low back pain in humans and animal models. Spine Journal. doi:10.1016/j.spinee.2013.07.490

Oikawa, Y., Ohtori, S., Koshi, T., Takaso, M., Inoue, G., Orita, S., … Takahashi, K. (2012a). Lumbar Disc Degeneration Induces Persistent Groin Pain. Spine, 37(2), 114–118. doi:10.1097/BRS.0b013e318210e6b5

Oikawa, Y., Ohtori, S., Koshi, T., Takaso, M., Inoue, G., Orita, S., … Takahashi, K. (2012b). Lumbar Disc Degeneration Induces Persistent Groin Pain. Spine, 37, 114–118. doi:10.1097/BRS.0b013e318210e6b5

Oki, S., Matsuda, Y., Shibata, T., Okumura, H., & Desaki, J. (1996). Morphologic differences of the vascular buds in the vertebral endplate: scanning electron microscopic study. Spine, 21(2), 174–177. doi:10.1097/00007632-199601150-00003

Okura, K., Kato, T., Montplaisir, J. Y., Sessle, B. J., & Lavigne, G. J. (2006). Quantitative analysis of surface EMG activity of cranial and leg muscles across sleep stages in human. Clinical Neurophysiology, 117, 269–278. doi:10.1016/j.clinph.2005.10.003

Okura, K., Lavigne, G. J., Huynh, N., Manzini, C., Fillipini, D., & Montplaisir, J. Y. (2008). Comparison of sleep variables between chronic widespread musculoskeletal pain, insomnia, periodic leg movements syndrome and control subjects in a clinical sleep medicine practice. Sleep Medicine, 9, 352–361. doi:10.1016/j.sleep.2007.07.007

On Refl ection Eye don ’ t believe it. (2007), 369, 2007.

Orleans, N. (2007). [ black small square ] Materials and Methods, 21(5), 1–15.

Osborne,  a. C., Lamb, K. J., Lewthwaite, J. C., Dowthwaite, G. P., & Pitsillides,  a. a. (2002). Short-term rigid and flaccid paralyses diminish growth of embryonic chick limbs and abrogate joint cavity formation but differentially preserve pre-cavitated joints. Journal of Musculoskeletal Neuronal Interactions, 2(5), 448–456.

Overeem, S., Reijntjes, R., Huyser, W., Lammers, G. J., & Van Dijk, J. G. (2004). Corticospinal excitability during laughter: Implications for cataplexy and the comparison with REM sleep atonia. Journal of Sleep Research, 13, 257–264. doi:10.1111/j.1365-2869.2004.00411.x

Ovid Schenck Neurology, Volume 46(2)_February 1996_388-393. (n.d.).

Page, M. S., Base, K., Text, E. A., Text, S. A., Preview, P., S, S. Y. M. B. B., … Carcinomas, T. (1997). Full Text, 2–9.

Pai, R. R., D’sa, B., Raghuveer, C. V, & Kamath,  a. (1999). Neovascularization of nucleus pulposus. A diagnostic feature of intervertebral disc prolapse. Spine, 24(8), 739–741. doi:10.1097/00007632-199904150-00002

Panjabi, M. M. (1992a). The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. Journal of Spinal Disorders, 5(4), 383–389; discussion 397. doi:10.1097/00002517-199212000-00001

Panjabi, M. M. (1992b). The stabilizing system of the spine. Part II. Neutral zone and instability hypothesis. Journal of Spinal Disorders. doi:10.1097/00002517-199212000-00002

Papadopoulou, V., Eckersley, R. J., Balestra, C., Karapantsios, T. D., & Tang, M. (2013a). A critical review of physiological bubble formation in hyperbaric decompression. Advances in Colloid and Interface Science, 191-192, 22–30. doi:10.1016/j.cis.2013.02.002

Papadopoulou, V., Eckersley, R. J., Balestra, C., Karapantsios, T. D., & Tang, M.-X. (2013b). A critical review of physiological bubble formation in hyperbaric decompression. Advances in Colloid and Interface Science, 191-192, 22–30. doi:10.1016/j.cis.2013.02.002

Pappou, I. P., Cammisa, F. P., & Girardi, F. P. (2007). Correlation of end plate shape on MRI and disc degeneration in surgically treated patients with degenerative disc disease and herniated nucleus pulposus. Spine Journal, 7, 32–38. doi:10.1016/j.spinee.2006.02.029

Park, C. O. (1997). Diurnal Variation in Lumbar MRI: Correlation between Signal Intensity, Disc Height, and Disc Bulge. Yonsei Medical Journal.

Pascal-Moussellard, H., Olindo, S., & Catonné, Y. (2006). 4:28110. Evaluation of Upper-Extremity Motor Function in Cervical Myelopathy by the Nine Hole Peg Test. The Spine Journal, 6, 54S. doi:10.1016/j.spinee.2006.06.376

Passmore, S. R., & Descarreaux, M. (2012). Performance based objective outcome measures and spinal manipulation. Journal of Electromyography and Kinesiology, 22(5), 697–707. doi:10.1016/j.jelekin.2012.02.005

Pearle,  a. D., Scanzello, C. R., George, S., Mandl, L. a., DiCarlo, E. F., Peterson, M., … Crow, M. K. (2007). Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis and Cartilage, 15, 516–523. doi:10.1016/j.joca.2006.10.010

Pearle, A. D., Warren, R. F., & Rodeo, S. a. (2005). Basic science of articular cartilage and osteoarthritis. Clinics in Sports Medicine, 24(1), 1–12. doi:10.1016/j.csm.2004.08.007

Pearson, A., Blood, E., Lurie, J., Tosteson, T., Abdu, W. a, Hillibrand, A., … Weinstein, J. (2010). Degenerative spondylolisthesis versus spinal stenosis: does a slip matter? Comparison of baseline characteristics and outcomes (SPORT). Spine, 35(3), 298–305. doi:10.1097/BRS.0b013e3181bdafd1

Peever, J., Luppi, P. H., & Montplaisir, J. (2014). Breakdown in REM sleep circuitry underlies REM sleep behavior disorder. Trends in Neurosciences, 37(5), 279–288. doi:10.1016/j.tins.2014.02.009

Peng, B., Hao, J., Hou, S., Wu, W., Jiang, D., Fu, X., & Yang, Y. (2006). Possible pathogenesis of painful intervertebral disc degeneration. Spine, 31(5), 560–566. doi:10.1097/01.brs.0000201324.45537.46

Peng, B., Hou, S., Wu, W., Zhang, C., & Yang, Y. (2006). The pathogenesis and clinical significance of a high-intensity zone (HIZ) of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain. European Spine Journal, 15, 583–587. doi:10.1007/s00586-005-0892-8

Peng, B., Li, D., & Pang, X. (2014). Degenerative Lumbar Spondylolisthesis with Testicular Pain. Pain Medicine (United States), 15(1), 169–170. doi:10.1111/pme.12246

Perlewitz, T. J., Haughton, V. M., Riley, L. H., Nguyen-Minh, C., & George, V. (1997). Effect of molecular weight on the diffusion of contrast media into cartilage. Spine, 22(23), 2707–2710. doi:10.1097/00007632-199712010-00001

Petersen, T., Larsen, K., & Jacobsen, S. (2007). One-year follow-up comparison of the effectiveness of McKenzie treatment and strengthening training for patients with chronic low back pain: outcome and prognostic factors. Spine, 32(26), 2948–2956. doi:10.1097/BRS.0b013e31815cda4a

Petra Valouchová, & Craig Liebenson. (2009). Self-management: Patient section. The New Abds. Journal of Bodywork and Movement Therapies, 13, 112–113. doi:10.1016/j.jbmt.2008.09.002

Pettman, E. (2007). A history of manipulative therapy. The Journal of Manual & Manipulative Therapy, 15(3), 165–174. doi:10.1179/106698107790819873

Pfirrmann, C. W., Metzdorf,  a, Zanetti, M., Hodler, J., & Boos, N. (2001). Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine, 26(17), 1873–1878.

Philippon, M. J., Nepple, J. J., Campbell, K. J., Dornan, G. J., Jansson, K. S., LaPrade, R. F., & Wijdicks, C. A. (2014). The hip fluid seal–Part I: the effect of an acetabular labral tear, repair, resection, and reconstruction on hip fluid pressurization. Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA, 22(4), 722–9. doi:10.1007/s00167-014-2874-z

Phimphasak, C., Swangnetr, M., Puntumetakul, R., Chatchawan, U., & Boucaut, R. (2015). Effects of seated lumbar extension postures on spinal height and lumbar range of motion during prolonged sitting. Ergonomics, (September), 1–9. doi:10.1080/00140139.2015.1052570

Pitsillides, A. A. (1999). Joint immobilization reduces synovial fluid hyaluronan concentration and is accompanied by changes in the synovial intimal cell populations. Rheumatology, 38(11), 1108–1112. doi:10.1093/rheumatology/38.11.1108

Plumb, M. S., & Aspden, R. M. (2005). The response of elderly human articular cartilage to mechanical stimuli in vitro. Osteoarthritis and Cartilage, 13, 1084–1091. doi:10.1016/j.joca.2005.07.002

Pohle-fro, R., Hackenbroch, M., Eysel, P., & Ganse, B. (2014). Assessment of Lumbar Intervertebral Disc Glycosaminoglycan Content by Gadolinium-Enhanced MRI before and after 21-Days of Head-Down-Tilt Bedrest, 9(11). doi:10.1371/journal.pone.0112104

Polus, B. I., Kimpton, A. J., & Walsh, M. J. (2011). Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study. Chiropractic & Manual Therapies, 19, 7. doi:10.1186/2045-709X-19-7

Pope, M. H., Goh, K. L., & Magnusson, M. L. (2002). Spine ergonomics. Annual Review of Biomedical Engineering, 4, 49–68. doi:10.1146/annurev.bioeng.4.092101.122107

Pospiech, J., Stolke, D., Wilke, H. J., & Claes, L. E. (1999). Intradiscal pressure recordings in the cervical spine. Neurosurgery, 44(February 1999), 379–385. doi:10.1097/00006123-199902000-00078

Postuma, R. B., & Montplaisir, J. (2009). Predicting Parkinson’s disease – why, when, and how? Parkinsonism and Related Disorders, 15, S105–S109. doi:10.1016/S1353-8020(09)70793-X

Pransky, G., Benjamin, K., Hill-Fotouhi, C., Fletcher, K. E., Himmelstein, J., & Katz, J. N. (2002). Work-related outcomes in occupational low back pain: a multidimensional analysis. Spine, 27(8), 864–870. doi:10.1097/00007632-200204150-00017

Pritzker, K. P. H., Gay, S., Jimenez, S. a., Ostergaard, K., Pelletier, J. P., Revell, K., … van den Berg, W. B. (2006). Osteoarthritis cartilage histopathology: Grading and staging. Osteoarthritis and Cartilage, 14, 13–29. doi:10.1016/j.joca.2005.07.014

Protapapas, M. G., & Cymet, T. C. (2002). Joint cracking and popping : Understanding noises that accompany articular release.

Przybyla, A., Pollintine, P., Bedzinski, R., & Adams, M. a. (2006). Outer annulus tears have less effect than endplate fracture on stress distributions inside intervertebral discs: Relevance to disc degeneration. Clinical Biomechanics, 21, 1013–1019. doi:10.1016/j.clinbiomech.2006.07.003

Przybyla, A. S., Skrzypiec, D., Pollintine, P., Dolan, P., & Adams, M. a. (2007). Strength of the cervical spine in compression and bending. Spine, 32(15), 1612–1620. doi:10.1097/BRS.0b013e318074c40b

Pulposus, N., & In, C. (2009). Full Text Cyclic Mechanical Stretch Stress Increases the Growth Rate and Collagen Synthesis of, 1–9.

Puntumetakul, R., Trott, P., Williams, M., & Fulton, I. (2009). Effect of time of day on the vertical spinal creep response. Applied Ergonomics, 40(1), 33–38. doi:10.1016/j.apergo.2008.01.016

Quintana, D. J., Garnero, P., Huebner, J. L., Charni-Ben Tabassi, N., & Kraus, V. B. (2008). PIIANP and HELIXII diurnal variation. Osteoarthritis and Cartilage, 16, 1192–1195. doi:10.1016/j.joca.2008.03.006

Quintner, J. L., Bove, G. M., & Cohen, M. L. (2014). Review, 1–8. doi:10.1093/rheumatology/keu471

Race,  a, Broom, N. D., & Robertson, P. (2000). Effect of loading rate and hydration on the mechanical properties of the disc. Spine, 25(6), 662–669. doi:10.1097/00007632-200003150-00003

Ract, I., Meadeb, J. M., Mercy, G., Cueff, F., Husson, J. L., & Guillin, R. (2014). A review of the value of MRI signs in low back pain. Diagnostic and Interventional Imaging. doi:10.1016/j.diii.2014.02.019

Radcliff, K. E., Ben-Galim, P., Dreiangel, N., Martin, S. B., Reitman, C. a., Lin, J. N., & Hipp, J. a. (2010). Comprehensive computed tomography assessment of the upper cervical anatomy: what is normal? Spine Journal, 10(3), 219–229. doi:10.1016/j.spinee.2009.12.021

Radiation of Sound. (n.d.). Retrieved March 29, 2015, from

Rahme, R., & Moussa, R. (2008). The modic vertebral endplate and marrow changes: Pathologic significance and relation to low back pain and segmental instability of the lumbar spine. American Journal of Neuroradiology, 29(May), 838–842. doi:10.3174/ajnr.A0925

Rainville, J., Hartigan, C., Martinez, E., Limke, J., Jouve, C., & Finno, M. (2004). Exercise as a treatment for chronic low back pain. The Spine Journal, 4, 106–115. doi:10.1016/S1529-9430(03)00174-8

Rajasekaran, S., Babu, J. N., Arun, R., Armstrong, B. R. W., Shetty, A. P., & Murugan, S. (2004). ISSLS prize winner: A study of diffusion in human lumbar discs: a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs. Spine, 29(23), 2654–2667. doi:10.1097/01.brs.0000148014.15210.64

Rajasekaran, S., Bajaj, N., Tubaki, V., Kanna, R. M., & Shetty, A. P. (2013). ISSLS Prize winner: The anatomy of failure in lumbar disc herniation: an in vivo, multimodal, prospective study of 181 subjects. Spine, 38(17), 1491–500. doi:10.1097/BRS.0b013e31829a6fa6

Rajasekaran, S., Naresh-Babu, J., & Murugan, S. (2007). Review of postcontrast MRI studies on diffusion of human lumbar discs. Journal of Magnetic Resonance Imaging, 25, 410–418. doi:10.1002/jmri.20853

Ramamurthy,  a. S., & Bhaskaran, P. (1979). Velocity Exponent for Erosion and Noise Due to Cavitation. Journal of Fluids Engineering. doi:10.1115/1.3448737

Randy Jinkins, J. (2004). The anatomic and physiologic basis of local, referred and radiating lumbosacral pain syndromes related to disease of the spine. Journal of Neuroradiology. Journal de Neuroradiologie, 31, 163–180. doi:10.1016/S0150-9861(04)96988-X

Rangayyan, R. M., & Wu, Y. (2009). Analysis of vibroarthrographic signals with features related to signal variability and radial-basis functions. Annals of Biomedical Engineering, 37(1), 156–163. doi:10.1007/s10439-008-9601-1

Raoul, S., Faure,  a, Robert, R., Rogez, J.-M., Hamel, O., Cuillère, P., & Le Borgne, J. (2003). Role of the sinu-vertebral nerve in low back pain and anatomical basis of therapeutic implications. Surgical and Radiologic Anatomy : SRA, 24(2002), 366–371. doi:10.1007/s00276-002-0084-8

Ratzon, N. Z., Yaros, T., Mizlik, A., & Kanner, T. (2000). Musculoskeletal symptoms among dentists in relation to work posture. Work (Reading, Mass.), 15, 153–158. Retrieved from

Recht, M. P., Goodwin, D. W., Winalski, C. S., & White, L. M. (2005). MRI of articular cartilage: Revisiting current status and future directions. American Journal of Roentgenology, 185(October), 899–914. doi:10.2214/AJR.05.0099

Reggars, J. W. (1999). Multiple channel recording of the articular crack associated with manipulation of the metacarpophalangeal joint. An observational study. Australasian Chiropractic & Osteopathy : Journal of the Chiropractic & Osteopathic College of Australasia, 8(1), 16–20. Retrieved from

Reid, D., Polson, K., & Johnson, L. (2012). Acromioclavicular Joint Separations Grades I – III A Review of the Literature and Development of Best. Sports Medicine, 42(8), 681–696.

Reitmaier, S., Schmidt, H., Ihler, R., Kocak, T., Graf, N., Ignatius, A., & Wilke, H. J. (2013). Preliminary Investigations on Intradiscal Pressures during Daily Activities: An In Vivo Study Using the Merino Sheep. PLoS ONE, 8(7), 1–10. doi:10.1371/journal.pone.0069610

Rekhviashvili, S. S. (2008). Single-Bubble Sonoluminescence Model, 34(12), 1072–1074. doi:10.1134/S1063785008120250

REM sleep behaviour disorder.pdf. (n.d.).

Rempel, D. M., Wang, P.-C., Janowitz, I., Harrison, R. J., Yu, F., & Ritz, B. R. (2007). A randomized controlled trial evaluating the effects of new task chairs on shoulder and neck pain among sewing machine operators: the Los Angeles garment study. Spine, 32(9), 931–938. doi:10.1097/01.brs.0000261028.88020.fc

Renema, W. K. J., Kan, H. E., Wieringa, B., & Heerschap, A. (2007). In vivo magnetic resonance spectroscopy of transgenic mouse models with altered high-energy phosphoryl transfer metabolism. NMR in Biomedicine, 20(6), 448–467. doi:10.1002/nbm

Res, D. (1985). Compressive Creep, 45.

Rihn, J. a, Lee, J. Y., Khan, M., Ulibarri, J. a, Tannoury, C., Donaldson, W. F., & Kang, J. D. (2007). Does lumbar facet fluid detected on magnetic resonance imaging correlate with radiographic instability in patients with degenerative lumbar disease? Spine, 32(14), 1555–1560. doi:10.1097/BRS.0b013e318067dc55

Roberts, N., Hogg, D., Whitehouse, G. H., & Dangerfield, P. (1998). Quantitative analysis of diurnal variation in volume and water content of lumbar intervertebral discs. Clinical Anatomy (New York, N.Y.), 11, 1–8. doi:10.1002/(SICI)1098-2353(1998)11:1<1::AID-CA1>3.0.CO;2-Z

Roberts, S., Evans, E. H., Kletsas, D., Jaffray, D. C., & Eisenstein, S. M. (2006). Senescence in human intervertebral discs. European Spine Journal, 15, 312–316. doi:10.1007/s00586-006-0126-8

Roberts, S., & Evans, H. (2006). Histology and Pathology of the human intervertebral disc. Journal of Bone and Joint Surgery, 2000.

Roberts, S., Urban, J. P., Evans, H., & Eisenstein, S. M. (1996). Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine, 21(4), 415–420. doi:10.1097/00007632-199602150-00003

Rodacki, C. L., Fowler, N. E., Rodacki,  a L., & Birch, K. (2001). Technical note: repeatability of measurement in determining stature in sitting and standing postures. Ergonomics, 44(1984), 1076–1085. doi:10.1080/00140130110099407

Rodriguez, A. G., Rodriguez-Soto, A. E., Burghardt, A. J., Berven, S., Majumdar, S., & Lotz, J. C. (2012). Morphology of the human vertebral endplate. Journal of Orthopaedic Research, 30, 280–287. doi:10.1002/jor.21513

Rohlmann,  a., Petersen, R., Schwachmeyer, V., Graichen, F., & Bergmann, G. (2012). Spinal loads during position changes. Clinical Biomechanics, 27(8), 754–758. doi:10.1016/j.clinbiomech.2012.04.006

Ross, J. K., Bereznick, D. E., & Mcgill, S. M. (2004). Determining Cavitation Location During Lumbar and Thoracic Spinal Manipulation Is Spinal Manipulation Accurate and Specific ?, 29(13), 1452–1457.

Roston, J. B., & Haines, R. W. (1947). Cracking in the metacarpo-phalangeal joint. Journal of Anatomy, 81, 165–173.

Roughley, P. J. (2004). Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine, 29(23), 2691–2699. doi:10.1097/01.brs.0000146101.53784.b1

Ruan, D., He, Q., Ding, Y., Hou, L., Li, J., & Luk, K. D. (2007). Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study. Lancet, 369, 993–999. doi:10.1016/S0140-6736(07)60496-6

Rubinstein, S. M., Terwee, C. B., Assendelft, W. J. J., de Boer, M. R., & van Tulder, M. W. (2012). Spinal manipulative therapy for acute low-back pain. The Cochrane Database of Systematic Reviews, 9, CD008880. doi:10.1002/14651858.CD008880.pub2

Rubinstein, S. M., Terwee, C. B., Assendelft, W. J. J., de Boer, M. R., & van Tulder, M. W. (2013). Spinal manipulative therapy for acute low back pain: an update of the cochrane review. Spine, 38(3), E158–77. doi:10.1097/BRS.0b013e31827dd89d

Rundell, S. a, Guerin, H. L., Auerbach, J. D., & Kurtz, S. M. (2009). Effect of nucleus replacement device properties on lumbar spine mechanics. Spine, 34(19), 2022–2032. doi:10.1097/BRS.0b013e3181af1d5a

Russell, D. A. (1999). Acoustic monopoles, dipoles, and quadrupoles: An experiment revisited. American Journal of Physics, 67(8), 660. doi:10.1119/1.19349

Rutges, J. P. H. J., Jagt van der, O. P., Oner, F. C., Verbout,  a. J., Castelein, R. J. M., Kummer, J. a., … Dhert, W. J. a. (2011). Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration. Osteoarthritis and Cartilage, 19, 89–95. doi:10.1016/j.joca.2010.09.010

Sakamaki, T., Sairyo, K., Sakai, T., Tamura, T., Okada, Y., & Mikami, H. (2009). Measurements of ligamentum flavum thickening at lumbar spine using MRI. Archives of Orthopaedic and Trauma Surgery, 129, 1415–1419. doi:10.1007/s00402-009-0849-1

Salih, F., Steinheimer, S., & Grosse, P. (2011). Excitability and recruitment patterns of spinal motoneurons in human sleep as assessed by F-wave recordings. Experimental Brain Research, 213, 1–8. doi:10.1007/s00221-011-2763-3

Sánchez Pérez, M., Gil Sierra,  a., Sánchez Martín,  a., Gallego Gómez, P., & Pereira Boo, D. (2012). Nomenclatura estandarizada de la patología discal. Radiologia, 54(xx), 503–512. doi:10.1016/j.rx.2011.11.005

Sánchez-Zuriaga, D., Adams, M. a, & Dolan, P. (2010). Is activation of the back muscles impaired by creep or muscle fatigue? Spine, 35(5), 517–525. doi:10.1097/BRS.0b013e3181b967ea

Sasaki, N., Henriksson, H. B., Runesson, E., Larsson, K., Sekiguchi, M., Kikuchi, S., … Brisby, H. (2012). Physical Exercise Affects Cell Proliferation in Lumbar Intervertebral Disc Regions in Rats. Spine, 37, 1440–1447. doi:10.1097/BRS.0b013e31824ff87d

Sato, K., Kikuchi, S., & Yonezawa, T. (1999). In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problems. Spine, 24(23), 2468–2474. doi:10.1097/00007632-199912010-00008

Sayson, J. V., & Hargens, A. R. (2008). Pathophysiology of low back pain during exposure to microgravity. Aviation Space and Environmental Medicine, 79(January), 365–373. doi:10.3357/ASEM.1994.2008

Sbriccoli, P., Solomonow, M., Zhou, B. H., Baratta, R. V., Lu, Y., Zhu, M. P., & Burger, E. L. (2004). Static load magnitude is a risk factor in the development of cumulative low back disorder. Muscle and Nerve, 29(February), 300–308. doi:10.1002/mus.10531

Sbriccoli, P., Yousuf, K., Kupershtein, I., Solomonow, M., Zhou, B.-H., Zhu, M. P., & Lu, Y. (2004). Static load repetition is a risk factor in the development of lumbar cumulative musculoskeletal disorder. Spine, 29(23), 2643–2653. doi:10.1097/01.brs.0000146052.44581.5f

Scannell, J. P., & McGill, S. M. (2009). Disc prolapse: evidence of reversal with repeated extension. Spine, 34(4), 344–350. doi:10.1097/BRS.0b013e31819712a6

Schenck, C. H., Bundlie, S. R., & Mahowald, M. W. (1996). Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology. doi:10.1212/WNL.46.2.388

Schmidt, H., Galbusera, F., Rohlmann, A., & Shirazi-Adl, A. (2013). What have we learned from finite element model studies of lumbar intervertebral discs in the past four decades? Journal of Biomechanics, 46, 2342–2355. doi:10.1016/j.jbiomech.2013.07.014

Schmidt, H., Galbusera, F., Wilke, H.-J., & Shirazi-Adl, A. (2011). Remedy for fictive negative pressures in biphasic finite element models of the intervertebral disc during unloading. Computer Methods in Biomechanics and Biomedical Engineering, 14(932223628), 293–303. doi:10.1080/10255842.2010.481287

Schmidt, H., Heuer, F., & Wilke, H. J. (2009). Dependency of disc degeneration on shear and tensile strains between annular fiber layers for complex loads. Medical Engineering and Physics, 31, 642–649. doi:10.1016/j.medengphy.2008.12.004

Schmidt, H., Kettler, A., Heuer, F., Simon, U., Claes, L., & Wilke, H.-J. (2007). Intradiscal pressure, shear strain, and fiber strain in the intervertebral disc under combined loading. Spine, 32(7), 748–755. doi:10.1097/01.brs.0000259059.90430.c2

Schmidt, H., Midderhoff, S., Adkins, K., & Wilke, H. J. (2009). The effect of different design concepts in lumbar total disc arthroplasty on the range of motion, facet joint forces and instantaneous center of rotation of a L4-5 segment. European Spine Journal, 18, 1695–1705. doi:10.1007/s00586-009-1146-y

Schmidt, H., Shirazi-Adl, A., Galbusera, F., & Wilke, H. J. (2010). Response analysis of the lumbar spine during regular daily activities-A finite element analysis. Journal of Biomechanics, 43(10), 1849–1856. doi:10.1016/j.jbiomech.2010.03.035

Schmidt, T. a, & Sah, R. L. (2007). Effect of synovial fluid on boundary lubrication of articular cartilage. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society, 15(1), 35–47. doi:10.1016/j.joca.2006.06.005

Schnake, K. J., Putzier, M., Haas, N. P., & Kandziora, F. (2006). Mechanical concepts for disc regeneration. European Spine Journal, 15, 354–360. doi:10.1007/s00586-006-0176-y

Schneider, M., Haas, M., Glick, R., Stevans, J., & Landsittel, D. (2014). A Comparison of Spinal Manipulation Methods and usual Medical care for Acute and Sub-Acute Low Back Pain: A Randomized Clinical Trial. Spine. doi:10.1097/BRS.0000000000000724

Schneider, M., Sciences, R., Haas, M., Glick, R., & Medicine, P. (n.d.). A comparison of spinal manipulation methods and usual medical care for acute. doi:10.1097/BRS.0000000000000724

Schroeder, Y., Elliott, D. M., Wilson, W., Baaijens, F. P. T., & Huyghe, J. M. (2008a). Experimental and model determination of human intervertebral disc osmoviscoelasticity. Journal of Orthopaedic Research, 26, 1141–1146. doi:10.1002/jor.20632

Schroeder, Y., Elliott, D. M., Wilson, W., Baaijens, F. P. T., & Huyghe, J. M. (2008b). Experimental and model determination of human intervertebral disc osmoviscoelasticity. Journal of Orthopaedic Research, 26(August), 1141–1146. doi:10.1002/jor.20632

Schroeder, Y., Wilson, W., Huyghe, J. M., & Baaijens, F. P. T. (2006). Osmoviscoelastic finite element model of the intervertebral disc. European Spine Journal, 15, 361–371. doi:10.1007/s00586-006-0110-3

Schulte, T. L., Filler, T. J., Struwe, P., Liem, D., & Bullmann, V. (2010). Intra-Articular Meniscoid Folds in Thoracic Zygapophysial Joints, 35(6), 191–197.

Schulte, T. L., Leistra, F., Bullmann, V., Osada, N., Vieth, V., Marquardt, B., … Hackenberg, L. (2007). Disc height reduction in adjacent segments and clinical outcome 10 years after lumbar 360° fusion. European Spine Journal, 16, 2152–2158. doi:10.1007/s00586-007-0515-7

Schulze, M., Hartensuer, R., Gehweiler, D., Hölscher, U., Raschke, M. J., & Vordemvenne, T. (2012). Evaluation of a robot-assisted testing system for multisegmental spine specimens. Journal of Biomechanics, 45, 1457–1462. doi:10.1016/j.jbiomech.2012.02.013

Schwedt, T. J., & Dodick, D. W. (2006). Headaches and Their Relationship To Cerebrovascular and Cardiovascular Disease. CONTINUUM: Lifelong Learning in Neurology, 12, 194–212. doi:10.1212/01.CON.0000290511.19387.79

Screening vibroarthrography signals via adaptive segementation and linear prediation modeling.pdf. (n.d.).

Sekiguchi, M., Wakita, T., Fukuhara, S., Otani, K., Onishi, Y., Kikuchi, S., & Konno, S. (2011). Development and Validation of a Quality of Life Scale Specific for Lumbar Spinal Stenosis. Spine, 36, E1407–E1414. doi:10.1097/BRS.0b013e31821fd4b1

Sélard, E., Shirazi-Adl,  a, & Urban, J. P. G. (2003). Finite element study of nutrient diffusion in the human intervertebral disc. Spine, 28(17), 1945–1953; discussion 1953. doi:10.1097/01.BRS.0000087210.93541.23

Senna, M. K., & Machaly, S. a. (2011). Does maintained spinal manipulation therapy for chronic nonspecific low back pain result in better long-term outcome? Spine, 36(18), 1427–1437. doi:10.1097/BRS.0b013e3181f5dfe0

Setton, L. a, & Chen, J. (2006). Mechanobiology of the intervertebral disc and relevance to disc degeneration. The Journal of Bone and Joint Surgery. American Volume, 88 Suppl 2, 52–57. doi:10.2106/JBJS.F.00001

Setton, L. a. (2005). Cell mechanics and mechanobiology in the intervertebral disc. European Cells and Materials, 10(23), 22. doi:10.1097/01.brs.0000146050.57722.2a

Setton, L. a., Elliott, D. M., & Mow, V. C. (1999). Altered mechanics of cartilage with osteoarthritis: Human osteoarthritis and an experimental model of joint degeneration. Osteoarthritis and Cartilage, 7, 2–14. doi:10.1053/joca.1998.0170

Shastry, B. S. (2001). Parkinson disease: Etiology, pathogenesis and future of gene therapy. Neuroscience Research, 41, 5–12. doi:10.1016/S0168-0102(01)00254-1

Shen, J., Wang, H.-Y., Chen, J.-Y., & Liang, B.-L. (2006). Morphologic analysis of normal human lumbar dorsal root ganglion by 3D MR imaging. AJNR. American Journal of Neuroradiology, 27, 2098–103. Retrieved from

Shen, Y., Rangayyan, R., & Bell, G. (1995). Localization of knee joint cartilage patholog by multichannel vibroarthrography. Medical Engineering & …, 17(8). Retrieved from

Shepherd, S. M., Chang, E. Y., Rutledge, J. L., Huang, B., Trudell, D., & Resnick, D. L. (2013). Cartilage assessment of the metacarpophalangeal joints: Cadaveric study with magnetic resonance arthrography and finger traction. Clinical Imaging, 37(4), 718–722. doi:10.1016/j.clinimag.2012.12.006

Shido, O., Maruyama, M., Wada, A., Oda, K., Haque Md, A., & Kitagaki, H. (2006). Possible role of the internal vertebral venous plexus during exercise in humans. Journal of Thermal Biology, 31, 181–185. doi:10.1016/j.jtherbio.2005.11.009

Shigeta, Y., Ogawa, T., Venturin, J., Clark, G. T., & Enciso, R. (2008). The influence of age and BMI on intervertebral disc height and oropharyngeal airway in Japanese men and women. International Journal of Computer Assisted Radiology and Surgery, 3, 97–103. doi:10.1007/s11548-008-0204-y

Shin, G., D’Souza, C., & Liu, Y.-H. (2009). Creep and fatigue development in the low back in static flexion. Spine, 34(17), 1873–1878. doi:10.1097/BRS.0b013e3181aa6a55

Shirazi-Adl,  a., El-Rich, M., Pop, D. G., & Parnianpour, M. (2005). Spinal muscle forces, internal loads and stability in standing under various postures and loads – Application of kinematics-based algorithm. European Spine Journal, 14, 381–392. doi:10.1007/s00586-004-0779-0

Shiri, R., Karppinen, J., Leino-Arjas, P., Solovieva, S., Varonen, H., Kalso, E., … Viikari-Juntura, E. (2007). Cardiovascular and lifestyle risk factors in lumbar radicular pain or clinically defined sciatica: A systematic review. European Spine Journal, 16, 2043–2054. doi:10.1007/s00586-007-0362-6

Showalter, B. L., Malhotra, N. R., Vresilovic, E. J., & Elliott, D. M. (2014). Nucleotomy reduces the effects of cyclic compressive loading with unloaded recovery on human intervertebral discs. Journal of Biomechanics, 47, 2633–2640. doi:10.1016/j.jbiomech.2014.05.018

Sidorkewicz, N., & Mcgill, S. M. (2014). Male Spine Motion During Coitus, 39(20), 1633–1639. doi:10.1097/BRS.0000000000000518

Siegel, J. M. (2005). Clues to the functions of mammalian sleep. Nature, 437(October), 1264–1271. doi:10.1038/nature04285

Siemionow, K., Klimczak, A., Brzezicki, G., Siemionow, M., & McLain, R. F. (2009). The effects of inflammation on glial fibrillary acidic protein expression in satellite cells of the dorsal root ganglion. Spine, 34(16), 1631–1637. doi:10.1097/BRS.0b013e3181ab1f68

Siklar, Z., Sanli, E., Dallar, Y., & Tanyer, G. (2005). Diurnal variation of height in children. Pediatrics International, 47(May 2003), 645–648. doi:10.1111/j.1442-200x.2005.02144.x

Silvis, M. L., Mosher, T. J., Smetana, B. S., Chinchilli, V. M., Flemming, D. J., Walker, E. a, & Black, K. P. (2011). High prevalence of pelvic and hip magnetic resonance imaging findings in asymptomatic collegiate and professional hockey players. The American Journal of Sports Medicine, 39, 715–721. doi:10.1177/0363546510388931

Simkin, P. a. (1995). Synovial perfusion and synovial fluid solutes. Annals of the Rheumatic Diseases, 54, 424–428. doi:10.1136/ard.54.5.424

Simon, P., Orías, A. a. E., Andersson, G. B. J., An, H. S., & Inoue, N. (2012). In Vivo Topographic Analysis of Lumbar Facet Joint Space Width Distribution in Healthy and Symptomatic Subjects. Spine, 37(12), 1058–1064. doi:10.1097/BRS.0b013e3182552ec9

Simunic, D. I., Broom, N. D., & Robertson, P. a. (2001). Biomechanical factors influencing nuclear disruption of the intervertebral disc. Spine, 26(11), 1223–1230. doi:10.1097/00007632-200106010-00010

Singh, A., Lu, Y., Chen, C., & M Cavanaugh, J. (2006). Mechanical properties of spinal nerve roots subjected to tension at different strain rates. Journal of Biomechanics, 39, 1669–1676. doi:10.1016/j.jbiomech.2005.04.023

Singh, K., Masuda, K., Thonar, E. J.-M. a, An, H. S., & Cs-Szabo, G. (2009). Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc. Spine, 34(1), 10–16. doi:10.1097/BRS.0b013e31818e5ddd

Sinha, R. K., Shah, S. a., Hume, E. L., & Tuan, R. S. (2002). The effect of a 5-day space flight on the immature rat spine. Spine Journal, 2, 239–243. doi:10.1016/S1529-9430(02)00197-3

Sivan, S., Neidlinger-Wilke, C., Würtz, K., Maroudas,  a, & Urban, J. P. G. (2006). Diurnal fluid expression and activity of intervertebral disc cells. Biorheology, 43, 283–291.

Skrzypiec, D. M., Pollintine, P., Przybyla, A., Dolan, P., & Adams, M. a. (2007). The internal mechanical properties of cervical intervertebral discs as revealed by stress profilometry. European Spine Journal, 16, 1701–1709. doi:10.1007/s00586-007-0458-z

Skrzypiec, D., Tarala, M., Pollintine, P., Dolan, P., & Adams, M. a. (2007). When are intervertebral discs stronger than their adjacent vertebrae? Spine, 32(22), 2455–2461. doi:10.1097/BRS.0b013e3181573b87

Slade, S. C., & Keating, J. L. (2007). Unloaded Movement Facilitation Exercise Compared to No Exercise or Alternative Therapy on Outcomes for People with Nonspecific Chronic Low Back Pain: A Systematic Review. Journal of Manipulative and Physiological Therapeutics, 30, 301–311. doi:10.1016/j.jmpt.2007.03.010

Smith, J. M., Szathmàry, E., Tran-, T. M., Versluis, M., Schmitz, B., & Heydt, A. Von Der. (2000). How Snapping Shrimp Snap : Through Cavitating Bubbles, 289(September), 2114–2118.

Smith, L. J., Nerurkar, N. L., Choi, K.-S., Harfe, B. D., & Elliott, D. M. (2011). Degeneration and regeneration of the intervertebral disc: lessons from development. Disease Models & Mechanisms, 4, 31–41. doi:10.1242/dmm.006403

Snook, S. H., Webster, B. S., McGorry, R. W., Fogleman, M. T., & McCann, K. B. (1998). The reduction of chronic nonspecific low back pain through the control of early morning lumbar flexion. A randomized controlled trial. Spine, 23(23), 2601–2607. doi:9854759

Sohn, H. M., You, J. W., & Lee, J. Y. (2004). The Relationship between Disc Degeneration and Morphologic Changes in the Intervertebral Foramen of the Cervical Spine: A Cadaveric MRI and CT Study. Journal of Korean Medical Science, 19, 101–106. doi:10.3346/jkms.2004.19.1.101

Solomonow, M., Baratta, R. V., Zhou, B. H., Burger, E., Zieske,  a., & Gedalia,  a. (2003). Muscular dysfunction elicited by creep of lumbar viscoelastic tissue. Journal of Electromyography and Kinesiology, 13, 381–396. doi:10.1016/S1050-6411(03)00045-2

Some Characteristics of Flow Past Backward Including Cavitation.pdf. (n.d.).

Sowa, G. a., Coelho, J. P., Vo, N. V., Pacek, C., Westrick, E., & Kang, J. D. (2012). Cells from Degenerative Intervertebral Discs Demonstrate Unfavorable Responses to Mechanical and Inflammatory Stimuli. American Journal of Physical Medicine & Rehabilitation, 91, 846–855. doi:10.1097/PHM.0b013e31825f145a

Sowa, G., & Agarwal, S. (2008). Cyclic tensile stress exerts a protective effect on intervertebral disc cells. American Journal of Physical Medicine & Rehabilitation / Association of Academic Physiatrists, 87(July), 537–544. doi:10.1097/PHM.0b013e31816197ee

Sowers, M., Jannausch, M., Stein, E., Jamadar, D., Hochberg, M., & Lachance, L. (2002). C-reactive protein as a biomarker of emergent osteoarthritis. Osteoarthritis and Cartilage, 10, 595–601. doi:10.1053/joca.2002.0800

Speltz, M. C., Olson, E. J., Hunt, L. M., Pool, R. R., Wilson, J. H., & Carlson, C. S. (2006). Equine intervertebral disk disease: A case report. Journal of Equine Veterinary Science, 26(9), 413–419. doi:10.1016/j.jevs.2006.07.007

Spontaneous movements with variuos seated-workplace adjustments.pdf. (n.d.).

Sprott, H., Muller, A., Heine, H., Abdelnoor, A., Awada, H., & Tamouza, R. (1993). HLA-B27 and the spondylarthropathies in Lebanon: comment on the article by Awada et al.

Spyropoulos, P., Papathanasiou, G., Georgoudis, G., Chronopoulos, E., Koutis, H., & Koumoutsou, F. (2007). Prevalence of low back pain in greek public office workers. Pain Physician, 10(5), 651–659.

Stefanakis, M., Al-Abbasi, M., Harding, I., Pollintine, P., Dolan, P., Tarlton, J., & Adams, M. a. (2012). Annulus Fissures Are Mechanically and Chemically Conducive to the Ingrowth of Nerves and Blood Vessels. Spine, 37, 1883–1891. doi:10.1097/BRS.0b013e318263ba59

Stefanakis, M., Luo, J., Pollintine, P., Dolan, P., & Adams, M. a. (2014). Mechanical Influences in Progressive Intervertebral Disc Degeneration. Spine, 39(17), 1365–1372. doi:10.1097/BRS.0000000000000389

Steinke, H., Hammer, N., Slowik, V., Stadler, J., Josten, C., Böhme, J., & Spanel-Borowski, K. (2010). Novel insights into the sacroiliac joint ligaments. Spine, 35(3), 257–263. doi:10.1097/BRS.0b013e3181b7c675

Stemper, B. D., Baisden, J. L., Yoganandan, N., Shender, B. S., & Maiman, D. J. (2014). Mechanical yield of the lumbar annulus: a possible contributor to instability: Laboratory investigation. Journal of Neurosurgery. Spine, 21(4), 608–13. doi:10.3171/2014.6.SPINE13401

Stokes, I. a F., & Iatridis, J. C. (2004). Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization. Spine, 29(23), 2724–2732. doi:10.1097/01.brs.0000146049.52152.da

Stokes, I. a, Stokes, I. a, Gwadera, J., Gwadera, J., Dimock, A., Dimock, A., … Aronsson, D. D. (2005). Modulation of vertebral and tibial growth by compression loading: diurnal versus full-time loading. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 23, 188–95. doi:10.1016/j.orthres.2004.06.012

Stoltz, J. F., Dumas, D., Wang, X., Payan, E., Mainard, D., Paulus, F., … Muller, S. (2000). Influence of mechanical forces on cells and tissues. Biorheology, 37, 3–14.

Stothart, J. P., & McGill, S. M. (2000). Stadiometry: On measurement technique to reduce variability in spine shrinkage measurement. Clinical Biomechanics, 15, 546–548. doi:10.1016/S0268-0033(00)00003-6

Strange, D. G. T., Fisher, S. T., Boughton, P. C., Kishen, T. J., & Diwan, A. D. (2010). Restoration of compressive loading properties of lumbar discs with a nucleus implant-a finite element analysis study. Spine Journal, 10(7), 602–609. doi:10.1016/j.spinee.2010.04.015

Sucu, H. K., & Gelal, F. (2006). Lumbar disk herniation with contralateral symptoms. European Spine Journal, 15, 570–574. doi:10.1007/s00586-005-0971-x

Sun, D. D. N., & Leong, K. W. (2004). A nonlinear hyperelastic mixture theory model for anisotropy, transport, and swelling of annulus fibrosus. Annals of Biomedical Engineering, 32(1), 92–102. doi:10.1023/B:ABME.0000007794.87408.1e

Supercavitation Applied Mathematical Modelling 37 (2013) 8836–8845. (n.d.).

Suri, P., Miyakoshi, A., Hunter, D. J., Jarvik, J. G., Rainville, J., Guermazi, A., … Katz, J. N. (2011). Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population. BMC Musculoskeletal Disorders, 12, 202. doi:10.1186/1471-2474-12-202

Suri, S., Gill, S. E., Massena de Camin, S., Wilson, D., McWilliams, D. F., & Walsh, D. a. (2007). Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Annals of the Rheumatic Diseases, 66, 1423–1428. doi:10.1136/ard.2006.063354

Tabakow, P., Jarmundowicz, W., Czapiga, B., Fortuna, W., Miedzybrodzki, R., Czyz, M., … Raisman, G. (2013). Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury. Cell Transplantation, 22, 1591–1612. doi:10.3727/096368912X663532

Takahashi, Y., Ohtori, S., & Takahashi, K. (2010). Dorsoventral organization of sensory nerves in the lumbar spine as indicated by double labeling of dorsal root ganglion neurons. Journal of Orthopaedic Science, 15, 578–583. doi:10.1007/s00776-010-1482-0

Takamori, Y., Arimizu, J., Izaki, T., Naito, M., & Kobayashi, T. (2010). Combined Measurement of Nerve Root Blood, 36(Xx), 57–62. doi:10.1097/BRS.0b013e3181ccb1d4

Takasaki, H., Hall, T., Jull, G., Kaneko, S., Iizawa, T., & Ikemoto, Y. (2009). The influence of cervical traction, compression, and spurling test on cervical intervertebral foramen size. Spine, 34(16), 1658–1662. doi:10.1097/BRS.0b013e3181a9c304

Takatalo, J., Karppinen, J., Niinimäki, J., Taimela, S., Näyhä, S., Järvelin, M.-R., … Tervonen, O. (2009). Prevalence of degenerative imaging findings in lumbar magnetic resonance imaging among young adults. Spine, 34(16), 1716–1721. doi:10.1097/BRS.0b013e3181ac5fec

Tamburin, S., Idone, D., & Zanette, G. (2007). Belly dancer’s myoclonus and chronic abdominal pain: Pain-related dysinhibition of a spinal cord central pattern generator? Parkinsonism and Related Disorders, 13, 317–320. doi:10.1016/j.parkreldis.2006.07.005

Tampier, C., Drake, J. D. M., Callaghan, J. P., & McGill, S. M. (2007). Progressive disc herniation: an investigation of the mechanism using radiologic, histochemical, and microscopic dissection techniques on a porcine model. Spine, 32(25), 2869–2874. doi:10.1097/BRS.0b013e31815b64f5

Tanaka, N., Fujimoto, Y., An, H. S., Ikuta, Y., & Yasuda, M. (2000). The anatomic relation among the nerve roots, intervertebral foramina, and intervertebral discs of the cervical spine. Spine, 25(3), 286–291. doi:10.1097/00007632-200002010-00005

Tang, J.-G., Hou, S., Shang, W.-L., & Wu, W.-W. (2010). Cervical myelopathy caused by anomalies at the level of atlas. Spine, 35(3), E77–E79. doi:10.1097/BRS.0b013e3181bb14e5

Tang, X.-Y., Liu, L.-J., Yang, H.-J., Peng, M.-X., & Liao, S.-H. (2007). Anatomic study of the synovial folds of the occipito-atlanto-axial joints. Clinical Anatomy (New York, N.Y.), 20(4), 376–81. doi:10.1002/ca.20408

Tate, M. L. K. (2005). Preface: Special issue on bone fluid flow: Organ to cell, lab bench to bedside, on earth and in space. Annals of Biomedical Engineering, 33(1), 1–2. doi:10.1007/s10439-005-8969-4

Teasell, R., & Bombardier, C. (2001). Employment-Related Factors in Chronic Pain and Chronic Pain Disability. Clin J Pain. doi:10.1097/00002508-200112001-00010

Tellakula, A. K. (2007). Acoustic Source Localization Using Time Delay Estimation. Technical University of Denmark, 012(August), 16–18. Retrieved from

Teo, E. C., & Ng, H. W. (2001). Evaluation of the role of ligaments, facets and disc nucleus in lower cervical spine under compression and sagittal moments using finite element method. Medical Engineering and Physics, 23, 155–164. doi:10.1016/S1350-4533(01)00036-4

Text, F. (2007). Try OvidSP ! Nature, 379(1), 718–721.

Text, F., & Scanner, O. M. R. (2007). Ovid : HARVEY : Invest Radiol , Volume 33 ( 8 ). August 1998 . 439-443, 33(August 1998), 5–10.

The, M. (2001). Role of uppermost superficial surface layer of articular, 241–250.

The, M. F. O. R., & Of, E. (2004). T He U Ncinate P Rocesses in B Irds and Their I Mplications for the B Reathing M Echanics of. Methods, 36, 272–279.

The Mendeley Support Team. (2011). Getting Started with Mendeley. Mendeley Desktop. London: Mendeley Ltd. Retrieved from

The structre, physiology and biomechanics of articluar cartilage. (n.d.).

The unifying concept of CSF-Cerebellar Ectopia 09-15-10 (3). (n.d.).

Thompson, R. E., Pearcy, M. J., & Barker, T. M. (2004). The mechanical effects of intervertebral disc lesions. Clinical Biomechanics, 19, 448–455. doi:10.1016/j.clinbiomech.2004.01.012

Thumbs. (n.d.).

Tillmann, V., & Clayton, P. E. (2001). Diurnal variation in height and the reliability of height measurements using stretched and unstretched techniques in the evaluation of short-term growth. Annals of Human Biology, 28, 195–206. doi:10.1080/03014460151056419

Timmins, F., & McCabe, C. (2005). How to conduct an effective literature search. Nursing Standard : Official Newspaper of the Royal College of Nursing, 20(11), 41–47. doi:10.7748/ns2005.

Toda, K., Harada, T., Ishizaki, F., Horie, N., & Yamada, T. (2007). Parkinson disease patient with fibromyalgia: a case report. Parkinsonism & Related Disorders, 13, 312–314. doi:10.1016/j.parkreldis.2006.05.001

Tofuku, K., Koga, H., Kawabata, N., Yuasa, S., Yone, K., & Komiya, S. (2007). Dorsally sequestered cervical disc herniation. Spine, 32(26), E837–E840. doi:10.1097/BRS.0b013e31815ce6c4

Tomaszewski, K. a., Saganiak, K., Gładysz, T., & Walocha, J. a. (2015). The biology behind the human intervertebral disc and its endplates. Folia Morphologica, 74(2), 157–168. doi:10.5603/FM.2015.0026

Tonetti, J., Potton, L., Riboud, R., Peoc’h, M., Passagia, J. G., & Chirossel, J. P. (2005). Morphological cervical disc analysis applied to traumatic and degenerative lesions. Surgical and Radiologic Anatomy, 27, 192–200. doi:10.1007/s00276-004-0309-0

Torun, F., Dolgun, H., Tuna, H., Attar, A., Uz, A., & Erdem, A. (2006). Morphometric analysis of the roots and neural foramina of the lumbar vertebrae. Surgical Neurology, 66, 148–151. doi:10.1016/j.surneu.2006.02.041

Torun, F., Tuna, H., Buyukmumcu, M., Caglar, S., & Baysefer, A. (2008). The lumbar roots and pedicles: a morphometric analysis and anatomical features. Journal of Clinical Neuroscience, 15, 895–899. doi:10.1016/j.jocn.2007.08.006

Travascio, F., Jackson, A. R., Brown, M. D., & Gu, W. Y. (2009). Relationship between solute transport properties and tissue morphology in human annulus fibrosus. Journal of Orthopaedic Research, 27, 1625–1630. doi:10.1002/jor.20927

Treleaven, J. (2011). Dizziness, Unsteadiness, Visual Disturbances, and Postural Control. Spine, 36(25), S211–S217. doi:10.1097/BRS.0b013e3182387f78

Tsantrizos, A., Ito, K., Aebi, M., & Steffen, T. (2005). Internal strains in healthy and degenerated lumbar intervertebral discs. Spine, 30(19), 2129–2137. doi:10.1097/01.brs.0000181052.56604.30

Tschoeke, S. K., Hellmuth, M., Hostmann, A., Robinson, Y., Ertel, W., Oberholzer, A., & Heyde, C. E. (2008). Apoptosis of human intervertebral discs after trauma compares to degenerated discs involving both receptor-mediated and mitochondrial-dependent pathways. Journal of Orthopaedic Research, 26, 999–1006. doi:10.1002/jor.20601

Tsirikos, A. I., Haddo, O., & Noordeen, H. H. (2004). Spinal manifestations in a patient with congenital insensitivity to pain. Journal of Spinal Disorders & Techniques, 17, 326–330. doi:10.1097/01.bsd.0000096271.75373.04

Ulrich, J. a, Liebenberg, E. C., Thuillier, D. U., & Lotz, J. C. (2007). ISSLS prize winner: repeated disc injury causes persistent inflammation. Spine, 32(25), 2812–2819. doi:10.1097/BRS.0b013e31815b9850

Unger, D. L. (1998). Does knuckle cracking lead to arthritis of the fingers? Arthritis and Rheumatism, 41(5), 949–50. doi:10.1002/1529-0131(199805)41:5<949::AID-ART36>3.0.CO;2-3

Unsworth, A., Dowson, D., & Wright, V. (1971).  ’ Cracking joints ’ A bioengineering study of cavitation in the metacarpophalangeal joint, 348–358.

Upton, M. L., Chen, J., Guilak, F., & Setton, L. a. (2003). Differential effects of static and dynamic compression on meniscal cell gene expression. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 21(10), 963–969. doi:10.1016/S0736-0266(03)00063-9

Urban, J. P. G., & Roberts, S. (2003). Degeneration of the intervertebral disc. Arthritis Research & Therapy, 5, 120–130. doi:10.1186/ar629

Urban, J. P. G., Roberts, S., & Ralphs, J. R. (2000a). The Nucleus of the Intervertebral Disc from Development to Degeneration1. American Zoologist, 40, 53–61. doi:10.1668/0003-1569(2000)040[0053:TNOTID]2.0.CO;2

Urban, J. P. G., Roberts, S., & Ralphs, J. R. (2000b). The Nucleus of the Intervertebral Disc from Development to Degeneration1. American Zoologist, 40(1), 53–61. doi:10.1668/0003-1569(2000)040[0053:TNOTID]2.0.CO;2

Urban, J. P. G., Smith, S., & Fairbank, J. C. T. (2004). Nutrition of the intervertebral disc. Spine, 29(23), 2700–2709. doi:10.1097/01.brs.0000146499.97948.52

Urban, J. P. G., & Winlove, C. P. (2007). Pathophysiology of the intervertebral disc and the challeges for MRI. Journal of Magnetic Resonance Imaging, 25, 419–432. doi:10.1002/jmri.20874

Urban, J. P., Holm, S., Maroudas,  a, & Nachemson,  a. (n.d.). Nutrition of the intervertebral disk. An in vivo study of solute transport. Clinical Orthopaedics and Related Research, 101–114.

Valdueza, J. M., von Münster, T., Hoffman, O., Schreiber, S., & Einhäupl, K. M. (2000). Postural dependency of the cerebral venous outflow. Lancet, 355, 200–201. doi:10.1016/S0140-6736(99)04804-7

Van Der Houwen, E. B., Baron, P., Veldhuizen,  a. G., Burgerhof, J. G. M., Van Ooijen, P. M. a, & Verkerke, G. J. (2010). Geometry of the intervertebral volume and vertebral endplates of the human spine. Annals of Biomedical Engineering, 38(Table 1), 33–40. doi:10.1007/s10439-009-9827-6

Van Der Kuip, M., Hoogland, P. V. J. M., & Groen, R. J. M. (1999). Human radicular veins: Regulation of venous reflux in the absence of valves. Anatomical Record, 254(April 1998), 173–180. doi:10.1002/(SICI)1097-0185(19990201)254:2<173::AID-AR3>3.0.CO;2-B

van der Veen,  a. J., van Dieën, J. H., Nadort,  a., Stam, B., & Smit, T. H. (2007). Intervertebral disc recovery after dynamic or static loading in vitro: Is there a role for the endplate? Journal of Biomechanics, 40, 2230–2235. doi:10.1016/j.jbiomech.2006.10.018

van der Veen, A. J., Mullender, M. G., Kingma, I., Van, J. H., & Smit, T. H. (2008). Contribution of verftebral bodies, endplates, and intervertebral discs to the compression creep of spinal motion segments. Journal of Biomechanics, 41, 1260–1268. doi:10.1016/j.jbiomech.2008.01.010

van der Veen, A. J., Mullender, M., Smit, T. H., Kingma, I., & van Dieën, J. H. (2005). Flow-related mechanics of the intervertebral disc: the validity of an in vitro model. Spine, 30(18), E534–E539. doi:10.1097/01.brs.0000179306.40309.3a

Van Der Werf, M., Lezuo, P., Maissen, O., Van Donkelaar, C. C., & Ito, K. (2007). Inhibition of vertebral endplate perfusion results in decreased intervertebral disc intranuclear diffusive transport. Journal of Anatomy, 211, 769–774. doi:10.1111/j.1469-7580.2007.00816.x

Van Deursen, D. L., Goossens, R. H. M., Evers, J. J. M., Van Der Helm, F. C. T., & Van Deursen, L. L. J. M. (2000). Length of the spine while sitting on a new concept for an office chair. Applied Ergonomics, 31, 95–98. doi:10.1016/S0003-6870(99)00030-7

van Deursen, D. L., Lengsfeld, M., Snijders, C. J., Evers, J. J., & Goossens, R. H. (2000). Mechanical effects of continuous passive motion on the lumbar spine in seating. J Biomech, 33, 695–699. doi:S0021929099002316 [pii]

Van Deursen, L. L., Patijn, J., Durinck, J. R., Brouwer, R., Van Erven-Sommers, J. R., & Vortman, B. J. (1999). Sitting and low back pain: The positive effect of rotatory dynamic stimuli during prolonged sitting. European Spine Journal, 8, 187–193. doi:10.1007/s005860050155

Van Deursen, L. L., Van Deursen, D. L., Snijders, C. J., & Wilke, H. J. (2005). Relationship between everyday activities and spinal shrinkage. Clinical Biomechanics, 20, 547–550. doi:10.1016/j.clinbiomech.2005.01.005

van Dieën, J. H., de Looze, M. P., & Hermans, V. (2001). Effects of dynamic office chairs on trunk kinematics, trunk extensor EMG and spinal shrinkage. Ergonomics, 44, 739–750. doi:10.1080/00140130120297

Vanwanseele, B., Lucchinetti, E., & Stüssi, E. (2002). The effects of immobilization on the characteristics of articular cartilage: Current concepts and future directions. Osteoarthritis and Cartilage, 10, 408–419. doi:10.1053/joca.2002.0529

Veres, S. P., Robertson, P. a, & Broom, N. D. (2008). ISSLS prize winner: microstructure and mechanical disruption of the lumbar disc annulus: part II: how the annulus fails under hydrostatic pressure. Spine, 33(25), 2711–2720. doi:10.1097/BRS.0b013e31817bb92c

Veres, S. P., Robertson, P. a, & Broom, N. D. (2009). The morphology of acute disc herniation: a clinically relevant model defining the role of flexion. Spine, 34(21), 2288–2296. doi:10.1097/BRS.0b013e3181a49d7e

Veres, S. P., Robertson, P. a, & Broom, N. D. (2010). ISSLS prize winner: how loading rate influences disc failure mechanics: a microstructural assessment of internal disruption. Spine, 35(21), 1897–1908. doi:10.1097/BRS.0b013e3181d9b69e

Vergroesen, P. P., van der Veen, A. J., van Royen, B. J., Kingma, I., & Smit, T. H. (2014). Intradiscal pressure depends on recent loading and correlates with disc height and compressive stiffness. European Spine Journal. doi:10.1007/s00586-014-3450-4

Vernon, H., & Mrozek, J. (2005). A revised definition of manipulation. Journal of Manipulative and Physiological Therapeutics, 28(1), 68–72. doi:10.1016/j.jmpt.2004.12.009

Vernon-Roberts, B., Moore, R. J., & Fraser, R. D. (2007). The natural history of age-related disc degeneration: the pathology and sequelae of tears. Spine, 32(25), 2797–2804. doi:10.1097/BRS.0b013e31815b64d2

Videman, T., & Nurminen, M. (2004). The occurrence of anular tears and their relation to lifetime back pain history: a cadaveric study using barium sulfate discography. Spine, 29(23), 2668–2676. doi:10.1097/01.brs.0000146461.27105.2b

Vieira-Pellenz, F., Oliva-Pascual-Vaca, Á., Rodriguez-Blanco, C., Heredia-Rizo, A. M., Ricard, F., & Almazán-Campos, G. (2014). Short-Term Effect of Spinal Manipulation on Pain Perception, Spinal Mobility, and Full Height Recovery in Male Subjects With Degenerative Disk Disease: A Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation. doi:10.1016/j.apmr.2014.05.002

Viejo-Fuertes, D., Liguoro, D., Rivel, J., Midy, D., & Guerin, J. (1998). Morphologic and histologic study of the ligamentum flavum in the thoraco-lumbar region. Surgical and Radiologic Anatomy : SRA, 20, 171–176. doi:10.1007/s00276-998-0171-6

Virtanen, I. M., Karppinen, J., Taimela, S., Ott, J., Barral, S., Kaikkonen, K., … Ala-Kokko, L. (2007). Occupational and genetic risk factors associated with intervertebral disc disease. Spine, 32(10), 1129–1134. doi:10.1097/01.brs.0000261473.03274.5c

von Heymann, W. J., Schloemer, P., Timm, J., & Muehlbauer, B. (2013). Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo. Spine, 38(7), 540–8. doi:10.1097/BRS.0b013e318275d09c

Vose, J. M. (2012). Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. American Journal of Hematology, 87, 604–609. doi:10.1002/ajh.23176

Vrahas, M. S., Mithoefer, K., & Joseph, D. (2004). The long-term effects of articular impaction. Clinical Orthopaedics and Related Research, (423), 40–43. doi:10.1097/01.blo.0000133567.28491.7d

Wade, K. R., Robertson, P. a., & Broom, N. D. (2012). On how nucleus-endplate integration is achieved at the fibrillar level in the ovine lumbar disc. Journal of Anatomy, 221, 39–46. doi:10.1111/j.1469-7580.2012.01507.x

Wagner, W. H., Regan, J. J., Leary, S. P., Lanman, T. H., Johnson, J. P., Rao, R. K., & Cossman, D. V. (2006). Access strategies for revision or explantation of the Charit?? lumbar artificial disc replacement. Journal of Vascular Surgery, 44(January 2001), 1266–1272. doi:10.1016/j.jvs.2006.07.046

Wainwright, D. K., Kleinteich, T., Kleinteich, A., Gorb, S. N., & Summers, A. P. (2013). Stick tight: suction adhesion on irregular surfaces in the northern clingfish. Biology Letters, 9(3), 20130234. doi:10.1098/rsbl.2013.0234

Walsh,  a. J. L., O’Neill, C. W., & Lotz, J. C. (2007). Glucosamine HCl alters production of inflammatory mediators by rat intervertebral disc cells in vitro. Spine Journal, 7, 601–608. doi:10.1016/j.spinee.2006.10.012

Walsh, A. J. L., & Lotz, J. C. (2004). Biological response of the intervertebral disc to dynamic loading. Journal of Biomechanics, 37, 329–337. doi:10.1016/S0021-9290(03)00290-2

Walsh, D. a., Mcwilliams, D. F., Turley, M. J., Dixon, M. R., Fransès, R. E., Mapp, P. I., & Wilson, D. (2010). Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis. Rheumatology, 49(June), 1852–1861. doi:10.1093/rheumatology/keq188

Walter, B. a., Korecki, C. L., Purmessur, D., Roughley, P. J., Michalek,  a. J., & Iatridis, J. C. (2011). Complex loading affects intervertebral disc mechanics and biology. Osteoarthritis and Cartilage, 19(May), 1011–1018. doi:10.1016/j.joca.2011.04.005

Wan, L., de Asla, R. J., Rubash, H. E., & Li, G. (2006). Determination of in-vivo articular cartilage contact areas of human talocrural joint under weightbearing conditions. Osteoarthritis and Cartilage, 14, 1294–1301. doi:10.1016/j.joca.2006.05.012

Wang, D.-L., Jiang, S.-D., & Dai, L.-Y. (2007). Biologic response of the intervertebral disc to static and dynamic compression in vitro. Spine, 32(23), 2521–2528. doi:10.1097/BRS.0b013e318158cb61

Wang, J. H. C., & Thampatty, B. P. (2006). An introductory review of cell mechanobiology. Biomechanics and Modeling in Mechanobiology, 5, 1–16. doi:10.1007/s10237-005-0012-z

Wang, S., Rui, Y., Lu, J., & Wang, C. (2014). Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies. Cell Proliferation, (13), 1–10. doi:10.1111/cpr.12121

Wang, X.-Q., Zheng, J.-J., Yu, Z.-W., Bi, X., Lou, S.-J., Liu, J., … Chen, P.-J. (2012). A meta-analysis of core stability exercise versus general exercise for chronic low back pain. PloS One, 7(12), 1–7. doi:10.1371/journal.pone.0052082

Wang, Y., Videman, T., & Battié, M. C. (2012a). ISSLS Prize Winner. Spine, 37(17), 1490–1496. doi:10.1097/BRS.0b013e3182608ac4

Wang, Y., Videman, T., & Battié, M. C. (2012b). Modic changes: prevalence, distribution patterns, and association with age in white men. The Spine Journal, 12, 411–416. doi:10.1016/j.spinee.2012.03.026

Waris, E., Eskelin, M., Hermunen, H., Kiviluoto, O., & Paajanen, H. (2007). Disc Degeneration in Low Back Pain. Spine, 32(6), 681–684. doi:10.1097/01.brs.0000257523.38337.96

Watson, P., Kernohan, W. G., & Mollan, R. a. (1989a). A study of the cracking sounds from the metacarpophalangeal joint. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine, 203(2), 109–118. doi:10.1243/PIME

Watson, P., Kernohan, W. G., & Mollan, R. A. (1989b). A study of the cracking sounds from the metacarpophalangeal joint. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine, 203(2), 109–18. Retrieved from

Webb, A. L., Collins, P., Rassoulian, H., & Mitchell, B. S. (2011a). Synovial folds – A pain in the neck? Manual Therapy. doi:10.1016/j.math.2010.11.004

Webb, A. L., Collins, P., Rassoulian, H., & Mitchell, B. S. (2011b). Synovial folds e A pain in the neck ? Manual Therapy, 16(2), 118–124. doi:10.1016/j.math.2010.11.004

Webb, A. L., Darekar, A. a, Sampson, M., & Rassoulian, H. (2009). Synovial folds of the lateral atlantoaxial joints: in vivo quantitative assessment using magnetic resonance imaging in healthy volunteers. Spine, 34(19), E697–702. doi:10.1097/BRS.0b013e3181ac8c6d

Webb, A. L., Rassoulian, H., & Mitchell, B. S. (2012). Morphometry of the synovial folds of the lateral atlanto-axial joints: The anatomical basis for understanding their potential role in neck pain. Surgical and Radiologic Anatomy, 34, 115–124. doi:10.1007/s00276-011-0834-6

weightlessness in space Scientific American. (n.d.).

Weisskopf, M., Ohnsorge, J. A. K., & Niethard, F. U. (2008). Intravertebral pressure during vertebroplasty and balloon kyphoplasty: an in vitro study. Spine, 33(2), 178–182. doi:10.1097/BRS.0b013e3181606139

Westbrook, J. L. (2012). Anatomy of the epidural space. Anaesthesia and Intensive Care Medicine, 13, 551–554. doi:10.1016/j.mpaic.2012.08.020

White, R. J., & Averner, M. (2001). Humans in space. Nature, 409(February), 1115–1118. doi:10.1038/35059243

White, T. L., & Malone, T. R. (1990). Effects of running on intervertebral disc height. The Journal of Orthopaedic and Sports Physical Therapy, 12(October), 139–146.

Whiting, P. F., Wolff, R. F., Deshpande, S., Di Nisio, M., Duffy, S., Hernandez, A. V., … Kleijnen, J. (2015). Cannabinoids for Medical Use. Jama, 313(24), 2456. doi:10.1001/jama.2015.6358

Widmyer, M. R., Utturkar, G. M., Leddy, H. a., Coleman, J. L., Spritzer, C. E., Moorman, C. T., … Guilak, F. (2013). High body mass index is associated with increased diurnal strains in the articular cartilage of the knee. Arthritis and Rheumatism, 65(10), 2615–2622. doi:10.1002/art.38062


Wilcox, R. K., Allen, D. J., Hall, R. M., Limb, D., Barton, D. C., & Dickson, R. a. (2004). A dynamic investigation of the burst fracture process using a combined experimental and finite element approach. European Spine Journal, 13, 481–488. doi:10.1007/s00586-003-0625-9

Wildeman, S., Lhuissier, H., Sun, C., Lohse, D., & Prosperetti, A. (2014). Tribonucleation of bubbles. Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10089–94. doi:10.1073/pnas.1321194111

Wilke, H. J., Neef, P., Caimi, M., Hoogland, T., & Claes, L. E. (1999). New in vivo measurements of pressures in the intervertebral disc in daily life. Spine, 24(8), 755–762. doi:10.1097/00007632-199904150-00005

Wilke, H., Neef, P., Hinz, B., Seidel, H., & Claes, L. (2001). Intradiscal pressure together with anthropometric data–a data set for the validation of models. Clinical Biomechanics (Bristol, Avon), 16 Suppl 1(1), S111–S126. doi:10.1016/S0268-0033(00)00103-0

Williams, M., Solomonow, M., Zhou, B. H., Baratta, R. V, & Harris, M. (2000). Multifidus spasms elicited by prolonged lumbar flexion. Spine, 25(22), 2916–2924. doi:10.1097/00007632-200011150-00014

Wing, P. C., Tsang, I. K., Susak, L., Gagnon, F., Gagnon, R., & Potts, J. E. (1991). Back pain and spinal changes in microgravity. The Orthopedic Clinics of North America.

Wisleder, D., Smith, M. B., Mosher, T. J., & Zatsiorsky, V. (2001). Lumbar spine mechanical response to axial compression load in vivo. Spine, 26(18), E403–E409. doi:10.1097/00007632-200109150-00004

With, A., & Mortality, T. (2006). Height Loss in Older Men, 166, 2546–2552.

Witt, K. L., & Vilensky, J. a. (2014). The anatomy of osteoarthritic joint pain. Clinical Anatomy, 27(May 2012), 451–454. doi:10.1002/ca.22120

Womack, W., Woldtvedt, D., & Puttlitz, C. M. (2008). Lower cervical spine facet cartilage thickness mapping. Osteoarthritis and Cartilage, 16, 1018–1023. doi:10.1016/j.joca.2008.01.007

Wuertz, K., Godburn, K., MacLean, J. J., Barbir, A., Donnelly, J. S., Roughley, P. J., … Iatridis, J. C. (2009). In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression. Journal of Orthopaedic Research, 27, 1235–1242. doi:10.1002/jor.20867

Yabuki, S., Kikuchi, S., Olmarker, K., & Myers, R. R. (1998). Acute effects of nucleus pulposus on blood flow and endoneurial fluid pressure in rat dorsal root ganglia. Spine, 23(23), 2517–2523.

Yagev, R., Levy, J., Shorer, Z., & Lifshitz, T. (1999). Congenital insensitivity to pain with anhidrosis: Ocular and systemic manifestations. American Journal of Ophthalmology, 127(98), 322–326. doi:10.1016/S0002-9394(98)00370-5

Yantzer, B. K., Freeman, T. B., Lee  3rd, W. E., Nichols, T., Inamasu, J., Guiot, B., & Johnson, W. M. (2007). Torsion-induced pressure distribution changes in human intervertebral discs: an in vitro study. Spine (Phila Pa 1976), 32(8), 881–884. doi:10.1097/01.brs.0000259838.40738.1f

Yates, J. P., Giangregorio, L., & McGill, S. M. (2010). The influence of intervertebral disc shape on the pathway of posterior/posterolateral partial herniation. Spine, 35(7), 734–739. doi:10.1097/BRS.0b013e3181ba3a60

Yates, J. P., & McGill, S. M. (2011). The effect of vibration and posture on the progression of intervertebral disc herniation. Spine, 36(Xx), 386–392. doi:10.1097/BRS.0b013e3181d2cece

Yeh, M.-L., Heggeness, M. H., Chen, H.-H., Jassawalla, J., & Luo, Z.-P. (2006). Compressive loading at the end plate directly regulates flow and deformation of the basivertebral vein: an analytical study. Journal of Orthopaedic Surgery and Research, 1, 18. doi:10.1186/1749-799X-1-18

Yilmazlar, S., Ikiz, I., Kocaeli, H., Tekdemir, I., & Adim, S. B. (2003). Details of fibroligamentous structures in the cervical unco-vertebral region: An obscure corner. Surgical and Radiologic Anatomy, 25, 50–53. doi:10.1007/s00276-002-0087-5

Yilmazlar, S., Kocaeli, H., Uz, A., & Tekdemir, I. (2003). Clinical importance of ligamentous and osseous structures in the cervical uncovertebral foraminal region. Clinical Anatomy, 16(January), 404–410. doi:10.1002/ca.10158

Yoon, S. T., Park, J. S., Kim, K. S., Li, J., Attallah-Wasif, E. S., Hutton, W. C., & Boden, S. D. (2004). ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo. Spine, 29(23), 2603–2611. doi:10.1097/01.brs.0000146103.94600.85

Yu, J., Tirlapur, U., Fairbank, J., Handford, P., Roberts, S., Winlove, P. P., … Urban, J. (2007). Microfibrils, elastin fibres and collagen fibres in the human intervertebral disc and bovine tail disc. Journal of Anatomy, 210, 460–471. doi:10.1111/j.1469-7580.2007.00707.x

Yukawa, Y., Kato, F., Ito, K., Horie, Y., Nakashima, H., Masaaki, M., … Wakao, N. (2009). “Ten second step test” as a new quantifiable parameter of cervical myelopathy. Spine, 34(1), 82–86. doi:10.1097/BRS.0b013e31818e2b19

Zalzal, P., Papini, M., Petruccelli, D., De Beer, J., & Winemaker, M. J. (2004). An In Vivo Biomechanical Analysis of the Soft-Tissue Envelope of Osteoarthritic Knees. Journal of Arthroplasty, 19(2), 217–223. doi:10.1016/j.arth.2003.09.008

Zarzur, E. (1984). Anatomic studies of the human ligamentum flavum. Anesthesia and Analgesia, 63, 499–502.

Zeng, H., Zhao, B., Israelachvili, J. N., & Tirrell, M. (2010). Liquid- to solid-like failure mechanism of thin polymer films at micro- and nanoscales. Macromolecules, 43, 538–542. doi:10.1021/ma901845z

Zhang, D., Chippada, U., & Jordan, K. (2007). Effect of the structural water on the mechanical properties of collagen-like microfibrils: A molecular dynamics study. Annals of Biomedical Engineering, 35(7), 1216–1230. doi:10.1007/s10439-007-9296-8

Zhang, P., Chen, X., & Fan, M. (2007). Signaling mechanisms involved in disuse muscle atrophy. Medical Hypotheses, 69, 310–321. doi:10.1016/j.mehy.2006.11.043

Zhang, Y. H., Zhao, C. Q., Jiang, L. S., Chen, X. D., & Dai, L. Y. (2008). Modic changes: A systematic review of the literature. European Spine Journal, 17, 1289–1299. doi:10.1007/s00586-008-0758-y

Zhang, Y., Lenart, B. a, Lee, J. K., Chen, D., Shi, P., Ren, J., … An, H. S. (2014). Histological features of endplates of the mammalian spine: from mice to men. Spine, 39, E312–7. doi:10.1097/BRS.0000000000000174

Zhang, Y., Sun, Z., Zhang, Z., Liu, J., & Guo, X. (2009). Risk factors for lumbar intervertebral disc herniation in Chinese population: a case-control study. Spine, 34(25), E918–E922. doi:10.1097/BRS.0b013e3181a3c2de

Zhao, F., Pollintine, P., Hole, B. D., Dolan, P., & Adams, M. a. (2005). Discogenic origins of spinal instability. Spine, 30(23), 2621–2630. doi:10.1097/01.brs.0000188203.71182.c0

Zheng, N., Yuan, X.-Y., Li, Y.-F., Chi, Y.-Y., Gao, H.-B., Zhao, X., … Sharkey, J. (2014). Definition of the To Be Named Ligament and Vertebrodural Ligament and Their Possible Effects on the Circulation of CSF. PloS One, 9(8), e103451. doi:10.1371/journal.pone.0103451

Zhou, H., Hou, S., Shang, W., Wu, W., Cheng, Y., Mei, F., & Peng, B. (2007). A new in vivo animal model to create intervertebral disc degeneration characterized by MRI, radiography, CT/discogram, biochemistry, and histology. Spine, 32(8), 864–872. doi:10.1097/01.brs.0000259835.31062.3d

Zhu, D., Gu, G., Wu, W., Gong, H., Zhu, W., Jiang, T., & Cao, Z. (2008). Micro-structure and mechanical properties of annulus fibrous of the L4-5 and L5-S1 intervertebral discs. Clinical Biomechanics, 23, 74–82. doi:10.1016/j.clinbiomech.2008.04.007

Zippel, K. C., Lillywhite, H. B., & Mladinich, C. R. J. (2001). New vascular system in reptiles: Anatomy and postural hemodynamics of the vertebral venous plexus in snakes. Journal of Morphology, 250, 173–184. doi:10.1002/jmor.1063

Zippel, K. C., Lillywhite, H. B., & Mladinich, C. R. J. (2003). Anatomy of the Crocodilian Spinal Vein. Journal of Morphology, 258, 327–335. doi:10.1002/jmor.10156

Zou, J., Yang, H., Miyazaki, M., Morishita, Y., Wei, F., McGovern, S., & Wang, J. C. (2009). Dynamic bulging of intervertebral discs in the degenerative lumbar spine. Spine, 34(23), 2545–2550. doi:10.1097/BRS.0b013e3181b32998